(Q33356962)

English

Helper-dependent adenoviral vectors mediate therapeutic factor VIII expression for several months with minimal accompanying toxicity in a canine model of severe hemophilia A

scientific article published on September 25, 2003

In more languages

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Helper-dependent adenoviral vectors mediate therapeutic factor VIII expression for several months with minimal accompanying toxicity in a canine model of severe hemophilia A (English)

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

0 references

Coagulation factor VIII

0 references

0 references

1 reference

based on heuristic

inferred from title

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14512318

14 March 2024

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

author name string

Chang Xin Shi

2

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Sandra Powell

3

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

David Hurlbut

4

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

David Lillicrap

6

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Brian D. Brown

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14512318

14 March 2024

Frank L. Graham

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14512318

14 March 2024

language of work or name

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publication date

25 September 2003

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

full work available at URL

https://ashpublications.org/blood/article-pdf/103/3/804/1694939/zh800304000804.pdf

Portable Document Format

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14512318

14 March 2024

http://ashpublications.org/blood/article-pdf/103/3/804/1694939/zh800304000804.pdf

Portable Document Format

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

103

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

804-810

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Safe passage: a plea for safety in hemophilia gene therapy

1

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Advances toward gene therapy for hemophilia at the millennium

2

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Improvements in adenoviral vector technology: overcoming barriers for gene therapy

4

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Absence of germline infection in male mice following intraventricular injection of adenovirus

5

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

In vivo evaluation of an adenoviral vector encoding canine factor VIII: high-level, sustained expression in hemophiliac mice.

6

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Systemic delivery of an adenoviral vector encoding canine factor VIII results in short-term phenotypic correction, inhibitor development, and biphasic liver toxicity in hemophilia A dogs.

9

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy

10

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs.

11

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal

13

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons

14

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Sustained human factor VIII expression in hemophilia A mice following systemic delivery of a gutless adenoviral vector

15

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

The canine factor VIII 3'-untranslated region and a concatemeric hepatocyte nuclear factor 1 regulatory element enhance factor VIII transgene expression in vivo

16

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Optimization of the helper-dependent adenovirus system for production and potency in vivo

17

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration

18

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Superior tissue-specific expression from tyrosinase and prostate-specific antigen promoters/enhancers in helper-dependent compared with first-generation adenoviral vectors

19

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

RNA template-specific polymerase chain reaction (RS-PCR): a novel strategy to reduce dramatically false positives

22

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Toxicity of a first-generation adenoviral vector in rhesus macaques

24

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Reports of adenovector "death" are greatly exaggerated

25

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector.

26

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Adenoviral vectors do not induce, inhibit, or potentiate human platelet aggregation

27

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Biodistribution and toxicity studies of VSVG-pseudotyped lentiviral vector after intravenous administration in mice with the observation of in vivo transduction of bone marrow

28

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression

29

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

The role of IL-6 in the inflammatory and humoral response to adenoviral vectors

31

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages

32

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Corticosteroids inhibit the production of inflammatory mediators in immature monocyte-derived DC and induce the development of tolerogenic DC3.

33

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity

34

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Use of a liver-specific promoter reduces immune response to the transgene in adenoviral vectors

36

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors

37

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Dangerous liaisons: the role of "danger" signals in the immune response to gene therapy

38

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Blood clearance rates of adenovirus type 5 in mice

39

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Correction of the nonlinear dose response improves the viability of adenoviral vectors for gene therapy of Fabry disease

40

1 reference

10.1182/BLOOD-2003-05-1426

https://api.crossref.org/works/10.1182/BLOOD-2003-05-1426

14 March 2024

Identifiers

10.1182/BLOOD-2003-05-1426

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

ResearchGate publication ID

0 references

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