(Q33375571)

26 July 2017

title

Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion (English)

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26 July 2017

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Lauren P Saunders

1

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26 July 2017

Amy Ouellette

2

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26 July 2017

Russ Bandle

3

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26 July 2017

William Chozen Chang

4

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26 July 2017

Hongwen Zhou

5

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26 July 2017

Raj N Misra

6

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26 July 2017

Enrique M De La Cruz

7

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26 July 2017

Demetrios T Braddock

8

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26 July 2017

publication date

1 October 2008

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Molecular Cancer Therapeutics

26 July 2017

published in

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26 July 2017

volume

7

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26 July 2017

issue

10

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26 July 2017

page(s)

3352-3362

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Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein

26 July 2017

cites work

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12 December 2020

Successful treatment of acute fascioliasis with bithionol

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12 December 2020

Ascitic fluid from human ovarian cancer patients contains growth factors necessary for intraperitoneal growth of human ovarian adenocarcinoma cells

1 reference

12 December 2020

A putative new growth factor in ascitic fluid from ovarian cancer patients: identification, characterization, and mechanism of action

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12 December 2020

Stability constants of metal complexes of bithionol, fenticlor and hexachlorophene

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12 December 2020

Correction for light absorption in fluorescence studies of protein-ligand interactions

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12 December 2020

Interfacial enzymology of glycerolipid hydrolases: lessons from secreted phospholipases A2.

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12 December 2020

Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells

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12 December 2020

Expression and transcriptional regulation of the PD-Ialpha/autotaxin gene in neuroblastoma

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12 December 2020

Cyclocreatine inhibits stimulated motility in tumor cells possessing creatine kinase

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12 December 2020

Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients

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12 December 2020

Autotaxin expression in non-small-cell lung cancer

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12 December 2020

Cloning of the gene encoding a novel thermostable alpha-galactosidase from Thermus brockianus ITI360.

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12 December 2020

Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells

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12 December 2020

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

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12 December 2020

A sensitive screening assay for secreted motility-stimulating factors

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12 December 2020

Electrospray ionization mass spectrometry analysis of lysophospholipids in human ascitic fluids: comparison of the lysophospholipid contents in malignant vs nonmalignant ascitic fluids

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12 December 2020

Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor

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12 December 2020

Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells

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12 December 2020

Role for 18:1 lysophosphatidic acid as an autocrine mediator in prostate cancer cells

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12 December 2020

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

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12 December 2020

Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase

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12 December 2020

Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells

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12 December 2020

The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site

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12 December 2020

Site-directed mutations in the tumor-associated cytokine, autotaxin, eliminate nucleotide phosphodiesterase, lysophospholipase D, and motogenic activities

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12 December 2020

Lysophosphatidic acid signaling: how a small lipid does big things

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12 December 2020

Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family

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12 December 2020

Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate

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12 December 2020

Characterization of human melanoma cell lines according to their migratory properties in vitro

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12 December 2020

Inhibition of pancreatic adenocarcinoma cellular invasiveness by blebbistatin: a novel myosin II inhibitor

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12 December 2020

Expression, regulation and function of autotaxin in thyroid carcinomas

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12 December 2020

Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets

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12 December 2020

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate

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12 December 2020

Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family

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12 December 2020

Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells

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12 December 2020

Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid

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12 December 2020

Fluorogenic phospholipid substrate to detect lysophospholipase D/autotaxin activity

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12 December 2020

Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis

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12 December 2020

Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development

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12 December 2020

Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid.

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12 December 2020

Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors

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12 December 2020

An essential oligomannosidic glycan chain in the catalytic domain of autotaxin, a secreted lysophospholipase-D

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12 December 2020

Alpha-substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPA

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12 December 2020

Inhibition of lysophospholipase D activity by unsaturated lysophosphatidic acids or seed extracts containing 1-linoleoyl and 1-oleoyl lysophosphatidic acid

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12 December 2020

Phosphatase-resistant analogues of lysophosphatidic acid: agonists promote healing, antagonists and autotaxin inhibitors treat cancer

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12 December 2020

10.1158/1535-7163.MCT-08-0463

Identifiers

DOI

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26 July 2017

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