(Q33387746)

26 July 2017

title

Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinities (English)

1 reference

26 July 2017

1 reference

1 reference

Adam P Silverman

1

1 reference

26 July 2017

Aron M Levin

series ordinal

2

1 reference

26 July 2017

Jennifer L Lahti

series ordinal

3

1 reference

26 July 2017

Jennifer R Cochran

series ordinal

4

1 reference

26 July 2017

language of work or name

English

0 references

publication date

12 November 2008

1 reference

Journal of Molecular Biology

26 July 2017

published in

1 reference

26 July 2017

volume

385

1 reference

26 July 2017

issue

4

1 reference

26 July 2017

page(s)

1064-1075

1 reference

Alternative binding proteins: biological activity and therapeutic potential of cystine-knot miniproteins

26 July 2017

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1 reference

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21 June 2018

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Isolating and engineering human antibodies using yeast surface display

21 June 2018

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Structural and molecular evolutionary analysis of Agouti and Agouti-related proteins

21 June 2018

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Targeting RGD recognizing integrins: drug development, biomaterial research, tumor imaging and targeting

21 June 2018

1 reference

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The potential of cystine-knot microproteins as novel pharmacophoric scaffolds in oral peptide drug delivery

21 June 2018

1 reference

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Improved mutants from directed evolution are biased to orthologous substitutions

21 June 2018

1 reference

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Vascular integrins in tumor angiogenesis: mediators and therapeutic targets

21 June 2018

1 reference

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Integrins: molecular targets in cancer therapy

21 June 2018

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Quantitative PET imaging of tumor integrin alphavbeta3 expression with 18F-FRGD2.

21 June 2018

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Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

21 June 2018

1 reference

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CNTO 95, a fully human monoclonal antibody that inhibits alphav integrins, has antitumor and antiangiogenic activity in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Use of phage display to probe the evolution of binding specificity and affinity in integrins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Engineered fibronectin type III domain with a RGDWXE sequence binds with enhanced affinity and specificity to human alphavbeta3 integrin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

21 June 2018

1 reference

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Crystal structure of the extracellular segment of integrin alpha Vbeta3

21 June 2018

1 reference

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Vitaxin applied molecular evolution.

21 June 2018

1 reference

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21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Development and application of cytotoxic T lymphocyte-associated antigen 4 as a protein scaffold for the generation of novel binding ligands

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Ligand binding to integrins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

In vitro evolution of a T cell receptor with high affinity for peptide/MHC.

21 June 2018

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21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Phage libraries displaying cyclic peptides with different ring sizes: ligand specificities of the RGD-directed integrins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Yeast surface display for screening combinatorial polypeptide libraries

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Protein loop grafting to construct a variant of tissue-type plasminogen activator that binds platelet integrin alpha IIb beta 3.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Structural and functional analyses of the Arg-Gly-Asp sequence introduced into human lysozyme

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Selection of peptides binding to the alpha 5 beta 1 integrin from phage display library.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

A peptide isolated from phage display libraries is a structural and functional mimic of an RGD-binding site on integrins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Peptide ligands for integrin alpha v beta 3 selected from random phage display libraries

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Requirement of vascular integrin alpha v beta 3 for angiogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Effects of modifications of the RGD sequence and its context on recognition by the fibronectin receptor.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Arg-Gly-Asp constrained within cyclic pentapeptides. Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Integrins: versatility, modulation, and signaling in cell adhesion

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Identification of novel peptide antagonists for GPIIb/IIIa from a conformationally constrained phage peptide library

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Engineering antibody affinity by yeast surface display.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Alpha v integrins as receptors for tumor targeting by circulating ligands.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Agonist-activated alphavbeta3 on platelets and lymphocytes binds to the matrix protein osteopontin.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha V beta 3, and alpha 5 beta 1 integrins

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925133

Echistatin. A potent platelet aggregation inhibitor from the venom of the viper, Echis carinatus

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19038268

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The role of the ninth and tenth type III domains of human fibronectin in cell adhesion

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19038268

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibition of platelet aggregation by grafting RGD and KGD sequences on the structural scaffold of small disulfide-rich proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19038268

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.JMB.2008.11.004

1 reference

26 July 2017

1 reference

26 July 2017

1 reference