(Q33389321)

26 July 2017

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title

Shiga toxin-associated hemolytic uremic syndrome: pathophysiology of endothelial dysfunction (English)

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α-D-galactosyl-(1→4)-β-D-galactosyl-(1→4)-β-D-glucosylceramide

26 July 2017

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ChEBI release 2020-05-28

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Carla Zoja

1

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26 July 2017

Simona Buelli

series ordinal

2

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26 July 2017

Marina Morigi

series ordinal

3

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26 July 2017

28 April 2010

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26 July 2017

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26 July 2017

25

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26 July 2017

11

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26 July 2017

2231-2240

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https://scigraph.springernature.com/pub.10.1007/s00467-010-1522-1

26 July 2017

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cites work

Fractalkine and CX3CR1 mediate leukocyte capture by endothelium in response to Shiga toxin

1 reference

https://api.crossref.org/works/10.1007%2FS00467-010-1522-1

Specific interaction of Escherichia coli O157:H7-derived Shiga-like toxin II with human renal endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00467-010-1522-1

Prognostic markers in diarrhoea-associated haemolytic-uraemic syndrome: initial neutrophil count, human neutrophil elastase and von Willebrand factor antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00467-010-1522-1

Verotoxin-1 stimulation of macrophage-like THP-1 cells up-regulates tissue factor expression through activation of c-Yes tyrosine kinase: Possible signal transduction in tissue factor up-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00467-010-1522-1

The association between idiopathic hemolytic uremic syndrome and infection by verotoxin-producing Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00467-010-1522-1

Enterohaemorrhagic Escherichia coli and Shigella dysenteriae type 1-induced haemolytic uraemic syndrome

21 January 2018

1 reference

12 December 2020

Shiga toxin and lipopolysaccharide induce platelet-leukocyte aggregates and tissue factor release, a thrombotic mechanism in hemolytic uremic syndrome

1 reference

12 December 2020

A DNA vaccine encoding the enterohemorragic Escherichia coli Shiga-like toxin 2 A2 and B subunits confers protective immunity to Shiga toxin challenge in the murine model

1 reference

12 December 2020

Shiga toxin 2 causes apoptosis in human brain microvascular endothelial cells via C/EBP homologous protein

1 reference

12 December 2020

Shiga toxin binds to activated platelets

1 reference

12 December 2020

Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome

1 reference

12 December 2020

Neutrophil-mediated endothelial injury in haemolytic uraemic syndrome

1 reference

12 December 2020

Kinetic analysis of binding between Shiga toxin and receptor glycolipid Gb3Cer by surface plasmon resonance

1 reference

12 December 2020

Shiga toxins, glycosphingolipid diversity, and endothelial cell injury

1 reference

12 December 2020

Verotoxin-1-induced up-regulation of adhesive molecules renders microvascular endothelial cells thrombogenic at high shear stress

1 reference

12 December 2020

Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura

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12 December 2020

Atypical hemolytic-uremic syndrome

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12 December 2020

Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome

1 reference

12 December 2020

Hypocomplementemia and leukocytosis in diarrhea-associated hemolytic uremic syndrome

1 reference

12 December 2020

Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins.

1 reference

12 December 2020

Role of tissue factor in thrombosis. Coagulation-inflammation-thrombosis circuit

1 reference

12 December 2020

Hemolytic uremic syndrome-associated Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers

1 reference

12 December 2020

Inter-kingdom signalling: communication between bacteria and their hosts

1 reference

12 December 2020

Activated platelets in paroxysmal nocturnal haemoglobinuria

1 reference

12 December 2020

The human complement system in thrombin-mediated platelet function

1 reference

12 December 2020

Treatment options for HUS secondary to Escherichia coli O157:H7.

1 reference

12 December 2020

Shiga toxin type 1 activates tumor necrosis factor-alpha gene transcription and nuclear translocation of the transcriptional activators nuclear factor-kappaB and activator protein-1.

1 reference

12 December 2020

Host and pathogen determinants of verocytotoxin-producing Escherichia coli-associated hemolytic uremic syndrome

1 reference

12 December 2020

Shiga toxins stimulate secretion of interleukin-8 from intestinal epithelial cells

1 reference

12 December 2020

Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome.

1 reference

12 December 2020

Escherichia coli O157:H7

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12 December 2020

Effect of Shiga toxin and Shiga-like toxins on eukaryotic cells

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12 December 2020

Interleukin-8 and polymorphoneutrophil leucocyte activation in hemolytic uremic syndrome of childhood

1 reference

12 December 2020

CXCL1/KC and CXCL2/MIP-2 are critical effectors and potential targets for therapy of Escherichia coli O157:H7-associated renal inflammation

1 reference

12 December 2020

Lack of specific binding of Shiga-like toxin (verocytotoxin) and non-specific interaction of Shiga-like toxin 2 antibody with human polymorphonuclear leucocytes

1 reference

12 December 2020

Infection by Shiga toxin-producing Escherichia coli: an overview

1 reference

12 December 2020

Detection of verocytotoxin bound to circulating polymorphonuclear leukocytes of patients with hemolytic uremic syndrome

1 reference

12 December 2020

The complement system in hemolytic-uremic syndrome in childhood

1 reference

12 December 2020

Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU

1 reference

12 December 2020

Verotoxin-1 promotes leukocyte adhesion to cultured endothelial cells under physiologic flow conditions.

1 reference

12 December 2020

Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum

1 reference

12 December 2020

Pathogenesis and evolution of virulence in enteropathogenic and enterohemorrhagic Escherichia coli

1 reference

12 December 2020

Endothelial cell diversity revealed by global expression profiling

1 reference

12 December 2020

Treatment and outcome of Shiga-toxin-associated hemolytic uremic syndrome (HUS).

1 reference

12 December 2020

Interactions of Shiga-like toxin with human peripheral blood monocytes

1 reference

12 December 2020

Comparative analysis of the abilities of Shiga toxins 1 and 2 to bind to and influence neutrophil apoptosis

1 reference

12 December 2020

Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation

1 reference

12 December 2020

Verotoxin-binding in human renal sections.

1 reference

12 December 2020

Furin-induced cleavage and activation of Shiga toxin.

1 reference

12 December 2020

Shigatoxin-1 binding and receptor expression in human kidneys do not change with age.

1 reference

12 December 2020

Safety and pharmacokinetics of chimeric anti-Shiga toxin 1 and anti-Shiga toxin 2 monoclonal antibodies in healthy volunteers

1 reference

12 December 2020

Shiga toxin of enterohemorrhagic Escherichia coli type O157:H7 promotes intestinal colonization.

1 reference

12 December 2020

Involvement of the fractalkine pathway in the pathogenesis of childhood hemolytic uremic syndrome

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12 December 2020

Factor H dysfunction in patients with atypical hemolytic uremic syndrome contributes to complement deposition on platelets and their activation

1 reference

12 December 2020

Molecular damage and induction of proinflammatory cytokines in human endothelial cells exposed to Shiga toxin 1, Shiga toxin 2, and alpha-sarcin

1 reference

12 December 2020

Chemokines and disease

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12 December 2020

An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their dissemination

1 reference

12 December 2020

Cytotoxic effect of Shiga toxin-1 on human proximal tubule cells.

1 reference

12 December 2020

EspFU is a translocated EHEC effector that interacts with Tir and N-WASP and promotes Nck-independent actin assembly

1 reference

12 December 2020

Tumor necrosis factor and interleukin-1 induce expression of the verocytotoxin receptor globotriaosylceramide on human endothelial cells: implications for the pathogenesis of the hemolytic uremic syndrome

1 reference

12 December 2020

Safety and pharmacokinetics of urtoxazumab, a humanized monoclonal antibody, against Shiga-like toxin 2 in healthy adults and in pediatric patients infected with Shiga-like toxin-producing Escherichia coli

1 reference

12 December 2020

Hemolytic uremic syndrome induced by lipopolysaccharide and Shiga-like toxin

1 reference

12 December 2020

Shiga toxin-associated hemolytic uremic syndrome: combined cytotoxic effects of shiga toxin and lipopolysaccharide (endotoxin) on human vascular endothelial cells in vitro.

1 reference

12 December 2020

Damage to nuclear DNA induced by Shiga toxin 1 and ricin in human endothelial cells

1 reference

12 December 2020

Activation of Src family kinase yes induced by Shiga toxin binding to globotriaosyl ceramide (Gb3/CD77) in low density, detergent-insoluble microdomains

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12 December 2020

Verotoxin biology: molecular events in vascular endothelial injury

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12 December 2020

Shiga toxin-1 regulation of cytokine production by human glomerular epithelial cells

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12 December 2020

Shiga toxin-2 triggers endothelial leukocyte adhesion and transmigration via NF-kappaB dependent up-regulation of IL-8 and MCP-1.

1 reference

12 December 2020

Evidence that verotoxins (Shiga-like toxins) from Escherichia coli bind to P blood group antigens of human erythrocytes in vitro

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12 December 2020

Interactions between Shiga toxins and human polymorphonuclear leukocytes

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12 December 2020

High incidence of serum antibodies to Escherichia coli O157 lipopolysaccharide in children with hemolytic-uremic syndrome

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12 December 2020

Induction of apoptosis in normal human renal tubular epithelial cells by Escherichia coli Shiga toxins 1 and 2

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12 December 2020

Shigatoxin-induced endothelin-1 expression in cultured podocytes autocrinally mediates actin remodeling

1 reference

12 December 2020

Verotoxin receptor glycolipid in human renal tissue.

1 reference

12 December 2020

No direct effects of Shiga toxin 1 and 2 on the aggregation of human platelets in vitro

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12 December 2020

Verotoxin and neuraminidase induced platelet aggregating activity in plasma: their possible role in the pathogenesis of the haemolytic uraemic syndrome

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12 December 2020

Hemolytic Uremic Syndrome

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12 December 2020

Impaired neutrophils in children with the typical form of hemolytic uremic syndrome

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12 December 2020

Impairment of platelet aggregation in hemolytic uremic syndrome: evidence for platelet "exhaustion"

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12 December 2020

Shiga toxin activates complement and binds factor H: evidence for an active role of complement in hemolytic uremic syndrome

1 reference

12 December 2020

Dissecting virulence: systematic and functional analyses of a pathogenicity island

1 reference

12 December 2020

Monocyte chemoattractant protein-1 and interleukin-8 levels in urine and serum of patents with hemolytic uremic syndrome

1 reference

12 December 2020

Shiga toxins do not directly stimulate alpha-granule secretion or enhance aggregation of human platelets

1 reference

12 December 2020

Alternative pathway of complement in children with diarrhea-associated hemolytic uremic syndrome

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12 December 2020

Verotoxin and ricin have novel effects on preproendothelin-1 expression but fail to modify nitric oxide synthase (ecNOS) expression and NO production in vascular endothelium

1 reference

12 December 2020

Hemolytic uremic syndrome in children: platelet aggregation and membrane glycoproteins

1 reference

12 December 2020

TccP is an enterohaemorrhagic Escherichia coli O157:H7 type III effector protein that couples Tir to the actin-cytoskeleton

1 reference

12 December 2020

Attaching effacing Escherichia coli and paradigms of Tir-triggered actin polymerization: getting off the pedestal

1 reference

12 December 2020

Interventions for hemolytic uremic syndrome and thrombotic thrombocytopenic purpura: a systematic review of randomized controlled trials

1 reference

12 December 2020

Renal histopathology in fatal cases of diarrhoea-associated haemolytic uraemic syndrome. British Association for Paediatric Nephrology

1 reference

12 December 2020

Hemolytic uremic syndrome; pathogenesis, treatment, and outcome

1 reference

12 December 2020

Soluble P-selectin is present in normal circulation and its plasma level is elevated in patients with thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome

1 reference

12 December 2020

A 20-year population-based study of postdiarrheal hemolytic uremic syndrome in Utah.

1 reference

12 December 2020

Cytokines in haemolytic uraemic syndrome associated with verocytotoxin-producing Escherichia coli infection

1 reference

12 December 2020

Role of verotoxin receptors in pathogenesis

1 reference

12 December 2020

Shiga toxin: biochemistry, genetics, mode of action, and role in pathogenesis

1 reference

12 December 2020

Shiga toxin-1 regulation of cytokine production by human proximal tubule cells

1 reference

12 December 2020

Endothelial heterogeneity in Shiga toxin receptors and responses.

1 reference

12 December 2020

The relationship between plasma levels of the factor VIII complex and platelet release products (beta-thromboglobulin and platelet factor 4) in children with the hemolytic-uremic syndrome

1 reference

12 December 2020

Shiga toxin 2 and lipopolysaccharide induce human microvascular endothelial cells to release chemokines and factors that stimulate platelet function

1 reference

12 December 2020

Effects of TNF alpha on verocytotoxin cytotoxicity in purified human glomerular microvascular endothelial cells.

1 reference

12 December 2020

Human platelet activation by C3a and C3a des-arg

1 reference

12 December 2020

IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation.

1 reference

12 December 2020

Differential carbohydrate epitope recognition of globotriaosyl ceramide by verotoxins and a monoclonal antibody

1 reference

12 December 2020

A murine model of HUS: Shiga toxin with lipopolysaccharide mimics the renal damage and physiologic response of human disease

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12 December 2020

Shiga toxin binds human platelets via globotriaosylceramide (Pk antigen) and a novel platelet glycosphingolipid

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12 December 2020

Detergent-resistant globotriaosyl ceramide may define verotoxin/glomeruli-restricted hemolytic uremic syndrome pathology

1 reference

12 December 2020

Environmental prevention of human disease from verocytotoxin-producing Escherichia coli

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12 December 2020

Controlling injection: regulation of type III secretion in enterohaemorrhagic Escherichia coli

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12 December 2020

Effects of verocytotoxin-1 on nonadherent human monocytes: binding characteristics, protein synthesis, and induction of cytokine release.

1 reference

12 December 2020

Lipopolysaccharide upregulates renal shiga toxin receptors in a primate model of hemolytic uremic syndrome

1 reference

12 December 2020

Bilateral nephrectomy stopped disease progression in plasma-resistant hemolytic uremic syndrome with neurological signs and coma

1 reference

12 December 2020

Shiga toxin 1 triggers a ribotoxic stress response leading to p38 and JNK activation and induction of apoptosis in intestinal epithelial cells

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12 December 2020

Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells

1 reference

12 December 2020

Long-term renal prognosis of diarrhea-associated hemolytic uremic syndrome: a systematic review, meta-analysis, and meta-regression

1 reference

12 December 2020

Fractalkine in vascular biology: from basic research to clinical disease

1 reference

12 December 2020

Verocytotoxin inhibits mitogenesis and protein synthesis in purified human glomerular mesangial cells without affecting cell viability: evidence for two distinct mechanisms

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12 December 2020

Binding and transfer of verocytotoxin by polymorphonuclear leukocytes in hemolytic uremic syndrome

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12 December 2020

Molecular and functional analysis of Shiga toxin–induced response patterns in human vascular endothelial cells

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12 December 2020

10.1007/S00467-010-1522-1

Identifiers

DOI

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Dimensions Publication ID

26 July 2017

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