(Q33393742)

26 July 2017

title

Platelet protein kinase C-theta deficiency with human RUNX1 mutation: PRKCQ is a transcriptional target of RUNX1. (English)

1 reference

26 July 2017

author name string

Gauthami Jalagadugula

1

1 reference

26 July 2017

Guangfen Mao

2

1 reference

26 July 2017

Gurpreet Kaur

3

1 reference

26 July 2017

Danny N Dhanasekaran

4

1 reference

26 July 2017

A Koneti Rao

5

1 reference

26 July 2017

language of work or name

English

0 references

publication date

20 January 2011

1 reference

Arteriosclerosis, Thrombosis, and Vascular Biology

26 July 2017

published in

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26 July 2017

volume

31

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26 July 2017

issue

4

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26 July 2017

page(s)

921-927

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Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4.

26 July 2017

cites work

1 reference

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Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency

21 June 2018

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Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen.

21 June 2018

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RUNX1/core binding factor A2 regulates platelet 12-lipoxygenase gene (ALOX12): studies in human RUNX1 haplodeficiency

21 June 2018

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Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation.

21 June 2018

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PKCtheta is required for hemostasis and positive regulation of thrombin-induced platelet aggregation and alpha-granule secretion

21 June 2018

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Protein kinase C[delta] differentially regulates platelet functional responses

21 June 2018

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Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis

21 June 2018

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Impaired activation of platelets lacking protein kinase C-theta isoform

21 June 2018

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PKCalpha regulates platelet granule secretion and thrombus formation in mice

21 June 2018

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Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets

21 June 2018

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Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation

21 June 2018

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Decreased platelet expression of myosin regulatory light chain polypeptide (MYL9) and other genes with platelet dysfunction and CBFA2/RUNX1 mutation: insights from platelet expression profiling

21 June 2018

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PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation

21 June 2018

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Normal and transforming functions of RUNX1: a perspective

21 June 2018

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A survey of the signaling pathways involved in megakaryocytic differentiation of the human K562 leukemia cell line by molecular and c-DNA array analysis.

21 June 2018

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Regulation of outside-in signaling in platelets by integrin-associated protein kinase C beta

21 June 2018

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Expression of protease activated receptor 3 (PAR3) is upregulated by induction of megakaryocyte phenotype in human erythroleukemia (HEL) cells

21 June 2018

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Core-binding factors in hematopoiesis and immune function

21 June 2018

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AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

21 June 2018

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A Chromatin Immunoprecipitation Screen Reveals Protein Kinase Cβ as a Direct RUNX1 Target Gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066073

Association of CBFA2 mutation with decreased platelet PKC-θ and impaired receptor-mediated activation of GPIIb-IIIa and pleckstrin phosphorylation: proteins regulated by CBFA2 play a role in GPIIb-IIIa activation

21 June 2018

1 reference

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Direct Demonstration of Involvement of Protein Kinase Cα in the Ca2+-induced Platelet Aggregation

21 June 2018

1 reference

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Fibronectin- and protein kinase C-mediated activation of ERK/MAPK are essential for proplateletlike formation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066073

In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis

21 June 2018

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Actin reorganization and proplatelet formation in murine megakaryocytes: the role of protein kinase calpha

21 June 2018

1 reference

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Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

21 June 2018

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Requirement for protein kinase C theta for cell cycle progression and formation of actin stress fibers and filopodia in vascular endothelial cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066073

Expression and activation of protein kinase C isoforms in a human megakaryocytic cell line.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066073

Protein kinase C isozymes in human megakaryoblastic leukemia cell line, MEG-01: possible involvement of the isozymes in the differentiation process of MEG-01 cells

21 June 2018

1 reference

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

21 June 2018

1 reference

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PMA-induced megakaryocytic differentiation of HEL cells is accompanied by striking modifications of protein kinase C catalytic activity and isoform composition at the nuclear level

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066073

Pleckstrin domain homology

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066073

Synergy between Ca2+ and protein kinase C is the major factor in determining the level of secretion from human platelets

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066073

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066073

Molecular cloning and expression of the major protein kinase C substrate of platelets

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066073

Regulation of megakaryocyte phenotype in human erythroleukemia cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066073

Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIB-IIIA complex of human platelets

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066073

A role for PKCtheta in outside-in alpha(IIb)beta3 signaling.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066073

Identification of protein kinase Calpha as an essential, but not sufficient, cytosolic factor for Ca2+-induced alpha- and dense-core granule secretion in platelets

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066073

Differential expression of protein kinase C isoform transcripts in human hematopoietic progenitors undergoing differentiation

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066073

Inhibition of protein kinase C suppresses megakaryocytic differentiation and stimulates erythroid differentiation in HEL cells.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066073

Cytoplasmic free Ca2+ in human platelets: Ca2+ thresholds and Ca-independent activation for shape-change and secretion

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066073

Dual role of platelet protein kinase C in thrombus formation: stimulation of pro-aggregatory and suppression of procoagulant activity in platelets

31 October 2018

1 reference

12 December 2020

Abnormal inside-out signal transduction-dependent activation of glycoprotein IIb-IIIa in a patient with impaired pleckstrin phosphorylation

1 reference

12 December 2020

Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors

1 reference

12 December 2020

Inhibition of platelet integrin alpha(IIb)beta(3) by peptides that interfere with protein kinases and the beta(3) tail

1 reference

12 December 2020

Human platelet Galphaq deficiency is associated with decreased Galphaq gene expression in platelets but not neutrophils

1 reference

12 December 2020

10.1161/ATVBAHA.110.221879

Identifiers

DOI

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26 July 2017

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26 July 2017

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