(Q33446966)

26 July 2017

title

Phase I trial and pharmacokinetic study of intravenous and oral alpha-difluoromethylornithine (English)

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26 July 2017

main subject

phase I clinical trial

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Griffin CA

1

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26 July 2017

Slavik M

2

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26 July 2017

Chien SC

3

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26 July 2017

Hermann J

4

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26 July 2017

Thompson G

5

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26 July 2017

Blanc O

6

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26 July 2017

Luk GD

7

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26 July 2017

Baylin SB

8

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26 July 2017

Abeloff MD

9

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26 July 2017

publication date

1 January 1987

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Investigational New Drugs

26 July 2017

published in

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26 July 2017

volume

5

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26 July 2017

issue

2

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26 July 2017

page(s)

177-186

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Polyamine metabolism and function

26 July 2017

cites work

1 reference

12 December 2020

Successful treatment with DL-alpha-difluoromethylornithine in established human small cell variant lung carcinoma implants in athymic mice

1 reference

12 December 2020

Treatment of metastatic Lewis lung carcinoma with DL-alpha-difluoromethylornithine

1 reference

12 December 2020

Effects of alpha-difluoromethylornithine alone and combined with adriamycin or vindesine on L1210 leukemia in mice, EMT6 solid tumors in mice, and solid tumors induced by injection of hepatoma tissue culture cells in rats

1 reference

12 December 2020

Inhibition of growth of human or hamster pancreatic cancer cell lines by alpha-difluoromethylornithine alone and combined with cis-diamminedichloroplatinum(II).

1 reference

12 December 2020

Inhibition of polyamine biosynthesis by alpha-difluoromethyl ornithine potentiates the cytotoxic effects of arabinosyl cytosine in HeLa cells

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12 December 2020

Chemotherapeutic implications of polyamine biosynthesis inhibition

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12 December 2020

Assay of alpha-difluoromethylornithine in body fluids and tissues by automatic amino-acid analysis

1 reference

12 December 2020

Anti-proliferative properties of DL-alpha-difluoromethyl ornithine in cultured cells. A consequence of the irreversible inhibition of ornithine decarboxylase

1 reference

12 December 2020

Ornithine decarboxylase: essential in proliferation but not differentiation of human promyelocytic leukemia cells

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12 December 2020

Polyamine biosynthesis is required for the maintenance of peripheral blood cell elements in the rat

1 reference

12 December 2020

Pneumocystis carinii pneumonia treated with alpha-difluoromethylornithine. A prospective study among patients with the acquired immunodeficiency syndrome.

1 reference

12 December 2020

Polyamines are necessary for the survival of human small-cell lung carcinoma in culture

1 reference

12 December 2020

Phase I trial and pharmacokinetic studies of alpha-difluoromethylornithine--an inhibitor of polyamine biosynthesis

1 reference

12 December 2020

Sensitization of 9L rat brain gliosarcoma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor.

1 reference

12 December 2020

Kinetics of alpha-difluoromethylornithine: an irreversible inhibitor of ornithine decarboxylase

1 reference

12 December 2020

Inhibition of EMT6 tumor growth by interference with polyamine biosynthesis; effects of alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase

1 reference

12 December 2020

Effect of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on L1210 leukemia in mice

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00203544

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Dimensions Publication ID

26 July 2017

1053598886

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