(Q33456643)

26 July 2017

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title

Advances in improving the quality and flexibility of compound management (English)

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26 July 2017

William P Janzen

1

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26 July 2017

Ioana G Popa-Burke

series ordinal

2

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26 July 2017

publication date

29 May 2009

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Journal of Biomolecular Screening

26 July 2017

published in

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26 July 2017

volume

14

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26 July 2017

issue

5

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26 July 2017

page(s)

444-451

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The future of high-throughput screening

26 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

High throughput screening in drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Hit discovery and hit-to-lead approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

High-throughput screening: update on practices and success

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057109335262

An efficient method for the detection and elimination of systematic error in high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Origin and evolution of high throughput screening

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057109335262

High-throughput screening assays for the identification of chemical probes

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057109335262

Streamlining lead discovery by aligning in silico and high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

The interdependence between screening methods and screening libraries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Property distribution of drug-related chemical databases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

"Plate cherry picking": a novel semi-sequential screening paradigm for cheaper, faster, information-rich compound selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Evaluation of an orthogonal pooling strategy for rapid high-throughput screening of proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Fragment-based activity space: smaller is better

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

New directions in library design and analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Identification of hits and lead structure candidates with limited resources by adaptive optimization

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

A support vector machines approach for virtual screening of active compounds of single and multiple mechanisms from large libraries at an improved hit-rate and enrichment factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Generation of new synthetic scaffolds using framework libraries selected and refined via medicinal chemist synthetic expertise

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Parallel personal comments on "classical" papers in combinatorial chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Compound library management

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

A standard operating procedure for assessing liquid handler performance in high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

History, evolution, and trends in compound management for high throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Modular tube/plate-based sample management: a business model optimized for scalable storage and processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

NanoStore: a concept for logistical improvements of compound handling in high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Obtaining and screening compound collections: a user's guide and a call to chemists

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

A cost-effective solution to reduce dead volume of a standard dispenser system by a factor of 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Screening library evolution through automation of solution preparation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Case study: impact of technology investment on lead discovery at Bristol-Myers Squibb, 1998-2006.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Compound Management for Quantitative High-Throughput Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Characterization of binary solvent mixtures of DMSO with water and other cosolvents

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

In silico estimation of DMSO solubility of organic compounds for bioscreening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

A novel approach to determine water content in DMSO for a compound collection repository

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

High-throughput purification of compound libraries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Development of a system to evaluate compound identity, purity, and concentration in a single experiment and its application in quality assessment of combinatorial libraries and screening hits

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Studies on repository compound stability in DMSO under various conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

The effect of room-temperature storage on the stability of compounds in DMSO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

The effect of freeze/thaw cycles on the stability of compounds in DMSO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Streamlined system for purifying and quantifying a diverse library of compounds and the effect of compound concentration measurements on the accurate interpretation of biological assay results

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Automated robotic liquid handling/laser-based nephelometry system for high throughput measurement of kinetic aqueous solubility

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Purifying the masses: integrating prepurification quality control, high-throughput LC/MS purification, and compound plating to feed high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Quality control in combinatorial chemistry: determinations of amounts and comparison of the "purity" of LC-MS-purified samples by NMR, LC-UV and CLND.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Maximizing automation in LC/MS high-throughput analysis and purification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

In silico approaches to prediction of aqueous and DMSO solubility of drug-like compounds: trends, problems and solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Cherry-picking in an orchard: unattended LC/MS analysis from an autosampler with >32,000 samples online

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

High-throughput purification of single compounds and libraries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Development and application of an automated solution stability assay for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Quality assessment and analysis of Biogen Idec compound library

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Biological assay challenges from compound solubility: strategies for bioassay optimization

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Just-in-time purification: an effective solution for cherry-picking and purifying active compounds from large legacy libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

When poor solubility becomes an issue: from early stage to proof of concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Drug delivery strategies for poorly water-soluble drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

High throughput solubility measurement in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Investigation of 3 industry-wide applied storage conditions for compound libraries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Development of reliable aqueous solubility models and their application in druglike analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Prediction of the aqueous solvation free energy of organic compounds by using autocorrelation of molecular electrostatic potential surface properties combined with response surface analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Changing requirements of purification as drug discovery programs evolve from hit discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Solubility challenge: can you predict solubilities of 32 molecules using a database of 100 reliable measurements?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Fluorescence spectroscopic profiling of compound libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Toward single-calibrant quantification in HPLC. A comparison of three detection strategies: evaporative light scattering, chemiluminescent nitrogen, and proton NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Universal response in liquid chromatography using charged aerosol detection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Structure-dependent response of a chemiluminescence nitrogen detector for organic compounds with adjacent nitrogen atoms connected by a single bond

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Determination of analyte concentration using the residual solvent resonance in (1)H NMR spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Needed: system dynamics for the drug discovery process

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Database Mining for pKa Prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

Phase Diagram for the System Water–Dimethylsulphoxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109335262

21 January 2018

Identifiers

DOI

10.1177/1087057109335262

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26 July 2017

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