(Q33477056)

27 July 2017

Utility of unbound plasma drug levels and P-glycoprotein transport data in prediction of central nervous system exposure (English)

1 reference

27 July 2017

H He

1

1 reference

27 July 2017

K A Lyons

2

1 reference

27 July 2017

X Shen

3

1 reference

27 July 2017

Z Yao

4

1 reference

27 July 2017

K Bleasby

5

1 reference

27 July 2017

G Chan

6

1 reference

27 July 2017

M Hafey

7

1 reference

27 July 2017

X Li

8

1 reference

27 July 2017

S Xu

9

1 reference

27 July 2017

G M Salituro

10

1 reference

27 July 2017

L H Cohen

11

1 reference

27 July 2017

W Tang

12

1 reference

27 July 2017

language of work or name

English

0 references

publication date

1 September 2009

1 reference

27 July 2017

1 reference

27 July 2017

39

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27 July 2017

9

1 reference

27 July 2017

687-693

1 reference

Potential role of ABC transporters as a detoxification system at the blood-CSF barrier.

27 July 2017

1 reference

https://api.crossref.org/works/10.1080%2F00498250903015402

Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903015402

Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: comparison of unbound concentration ratios to in vivo p-glycoprotein efflux ratios.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903015402

CSF as a surrogate for assessing CNS exposure: an industrial perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903015402

Relationship between exposure and nonspecific binding of thirty-three central nervous system drugs in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903015402

Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid/plasma concentration ratio

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903015402

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903015402

Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903015402

10.1080/00498250903015402

21 January 2018

Identifiers

DOI

1 reference

27 July 2017

1 reference