(Q33538715)

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Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213245%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9 (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213245%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

G protein-coupled receptor

0 references

human fibroblast

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213245%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

7

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213245%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

Trisha M Finlay

1

1 reference

Europe PubMed Central

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19 January 2020

Preethi Jayanth

2

1 reference

Europe PubMed Central

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19 January 2020

Schammim Ray Amith

3

1 reference

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19 January 2020

Alanna Gilmour

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213245%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Christina Guzzo

5

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213245%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Myron R Szewczuk

8

1 reference

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19 January 2020

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6 March 2010

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19 January 2020

Glycoconjugate Journal

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213245%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

27

1 reference

Europe PubMed Central

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19 January 2020

3

1 reference

Europe PubMed Central

PubMed publication ID

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19 January 2020

329-348

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213245%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Thymoquinone attenuates proinflammatory responses in lipopolysaccharide-activated mast cells by modulating NF-kappaB nuclear transactivation

1 reference

https://api.crossref.org/works/10.1007%2FS10719-010-9281-6

21 January 2018

Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition

1 reference

https://api.crossref.org/works/10.1007%2FS10719-010-9281-6

21 January 2018

Angiotensin II type 1 receptor-induced extracellular signal-regulated protein kinase activation is mediated by Ca2+/calmodulin-dependent transactivation of epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1007%2FS10719-010-9281-6

21 January 2018

Protective protein/cathepsin A rescues N-glycosylation defects in neuraminidase-1.

1 reference

https://api.crossref.org/works/10.1007%2FS10719-010-9281-6

21 January 2018

Dissecting the epidermal growth factor receptor signal transactivation pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neu1 desialylation of sialyl alpha-2,3-linked beta-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sialidase NEU3 is a peripheral membrane protein localized on the cell surface and in endosomal structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dependence of neurotrophic factor activation of Trk tyrosine kinase receptors on cellular sialidase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Limited inhibitory effects of oseltamivir and zanamivir on human sialidases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An analysis of radiotherapy data from the CNS cancer consortium's randomized prospective trial comparing AZQ to BCNU in the treatment of patients with primary malignant brain tumors. The CNS cancer consortium

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced expression of class I major histocompatibility complex gene (Dk) products on immunogenic variants of a spontaneous murine carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human sialidase NEU4 long and short are extrinsic proteins bound to outer mitochondrial membrane and the endoplasmic reticulum, respectively

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma membrane ganglioside sialidase regulates axonal growth and regeneration in hippocampal neurons in culture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The plasma membrane-associated sialidase MmNEU3 modifies the ganglioside pattern of adjacent cells supporting its involvement in cell-to-cell interactions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An efficient culture method for generating large quantities of mature mouse splenic macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for mitochondrial localization of a novel human sialidase (NEU4).

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the sialidase molecular defects in sialidosis patients suggests the structural organization of the lysosomal multienzyme complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic activity of lysosomal carboxypeptidase (cathepsin) A is required for proper elastic fiber formation and inactivation of endothelin-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The control of IL-4 gene expression in activated murine T lymphocytes: a novel role for neu-1 sialidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor-induced mobilization of a ganglioside-specific sialidase (NEU3) to membrane ruffles

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysosomal sialidase (neuraminidase-1) is targeted to the cell surface in a multiprotein complex that facilitates elastic fiber assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presentation of exogenous antigens by macrophages: analysis of major histocompatibility complex class I and II presentation and regulation by cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuraminidase-1 is required for the normal assembly of elastic fibers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunomodulatory and therapeutic properties of the Nigella sativa L. seed.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuraminidase 1 is a negative regulator of lysosomal exocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinases at a glance

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.).

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterodimerization of the sialidase NEU1 with the chaperone protective protein/cathepsin A prevents its premature oligomerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Neu4L sialidase and its substrate ganglioside GD3 in neuronal apoptosis induced by catechol metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma membrane-associated sialidase as a crucial regulator of transmembrane signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The elastin receptor complex transduces signals through the catalytic activity of its Neu-1 subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental change of sialidase neu4 expression in murine brain and its involvement in the regulation of neuronal cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monocyte differentiation up-regulates the expression of the lysosomal sialidase, Neu1, and triggers its targeting to the plasma membrane via major histocompatibility complex class II-positive compartments

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of phagocytosis in macrophages by neuraminidase 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning of mouse ganglioside sialidase and its increased expression in Neuro2a cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of Plasma Membrane-associated Sialidase Attenuates Insulin Signaling in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characterization of membrane type and ganglioside-specific sialidase (Neu3) expressed in E. coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymmetric membrane ganglioside sialidase activity specifies axonal fate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice deficient in Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dependence of pathogen molecule-induced toll-like receptor activation and cell function on Neu1 sialidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparing protein abundance and mRNA expression levels on a genomic scale

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular pathology of NEU1 gene in sialidosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sialidase expression in activated human T lymphocytes influences production of IFN-gamma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20213245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10719-010-9281-6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213245%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213245%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

ResearchGate publication ID

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