(Q33548284)

28 July 2017

Generation of human TRIM5alpha mutants with high HIV-1 restriction activity (English)

1 reference

28 July 2017

Q T Pham

1

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28 July 2017

A Bouchard

series ordinal

2

1 reference

28 July 2017

M G Grütter

series ordinal

3

1 reference

28 July 2017

L Berthoux

series ordinal

4

1 reference

28 July 2017

1 April 2010

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28 July 2017

1 reference

28 July 2017

17

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28 July 2017

7

1 reference

28 July 2017

859-871

1 reference

https://scigraph.springernature.com/pub.10.1038/gt.2010.40

28 July 2017

0 references

cites work

The tripartite motif family identifies cell compartments

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

TRIM5alpha mediates the postentry block to N-tropic murine leukemia viruses in human cells

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Intrinsic immunity: a front-line defense against viral attack

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

The control of viral infection by tripartite motif proteins and cyclophilin A.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

TRIM family proteins: retroviral restriction and antiviral defence

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Trim5alpha protein restricts both HIV-1 and murine leukemia virus

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Primate lentivirus capsid sensitivity to TRIM5 proteins

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Antiretroviral potential of human tripartite motif-5 and related proteins

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Molecular evolution of the antiretroviral TRIM5 gene.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

TRIM5alpha selectively binds a restriction-sensitive retroviral capsid

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Restriction of human immunodeficiency virus type 1 by TRIM-CypA occurs with rapid kinetics and independently of cytoplasmic bodies, ubiquitin, and proteasome activity

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Species-specific tropism determinants in the human immunodeficiency virus type 1 capsid

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Influence of gag on human immunodeficiency virus type 1 species-specific tropism

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Binding and susceptibility to postentry restriction factors in monkey cells are specified by distinct regions of the human immunodeficiency virus type 1 capsid

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Both TRIM5alpha and TRIMCyp have only weak antiviral activity in canine D17 cells

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

The human TRIM5alpha restriction factor mediates accelerated uncoating of the N-tropic murine leukemia virus capsid

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Proteasome inhibition reveals that a functional preintegration complex intermediate can be generated during restriction by diverse TRIM5 proteins

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Rapid turnover and polyubiquitylation of the retroviral restriction factor TRIM5.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Ubiquitination of E3 ubiquitin ligase TRIM5 alpha and its potential role

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Proteasomal degradation of TRIM5alpha during retrovirus restriction

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Visualization of a proteasome-independent intermediate during restriction of HIV-1 by rhesus TRIM5alpha

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Proteasome inhibitors uncouple rhesus TRIM5alpha restriction of HIV-1 reverse transcription and infection

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

All three variable regions of the TRIM5alpha B30.2 domain can contribute to the specificity of retrovirus restriction

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Patterns of evolution of host proteins involved in retroviral pathogenesis

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Species-specific variation in the B30.2(SPRY) domain of TRIM5alpha determines the potency of human immunodeficiency virus restriction

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Removal of arginine 332 allows human TRIM5alpha to bind human immunodeficiency virus capsids and to restrict infection

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

A single amino acid change in the SPRY domain of human Trim5alpha leads to HIV-1 restriction

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Genetic therapies against HIV.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Complete knockdown of CCR5 by lentiviral vector-expressed siRNAs and protection of transgenic macrophages against HIV-1 infection

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Inhibition of human immunodeficiency virus type 1 replication in primary macrophages by using Tat- or CCR5-specific small interfering RNAs expressed from a lentivirus vector

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Disruption of human TRIM5alpha antiviral activity by nonhuman primate orthologues

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Antiretroviral activity of ancestral TRIM5alpha.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

An invariant surface patch on the TRIM5alpha PRYSPRY domain is required for retroviral restriction but dispensable for capsid binding

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Retrovirus restriction by TRIM5alpha variants from Old World and New World primates

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Differential restriction of human immunodeficiency virus type 2 and simian immunodeficiency virus SIVmac by TRIM5alpha alleles

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Use of a transient assay for studying the genetic determinants of Fv1 restriction

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

A conserved mechanism of retrovirus restriction in mammals

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Retroviral restriction factors Fv1 and TRIM5alpha act independently and can compete for incoming virus before reverse transcription.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Implication of TRIM alpha and TRIMCyp in interferon-induced anti-retroviral restriction activities

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Alpha interferon enhances TRIM5alpha-mediated antiviral activities in human and rhesus monkey cells

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

HIV-1 at the immunological and T-lymphocytic virological synapse

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapses

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Mode of transmission affects the sensitivity of human immunodeficiency virus type 1 to restriction by rhesus TRIM5alpha

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Absconding with the Chaperone: Essential Cyclophilin–Gag Interaction in HIV-1 Virions

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Naturally occurring capsid substitutions render HIV-1 cyclophilin A independent in human cells and TRIM-cyclophilin-resistant in Owl monkey cells

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Arsenic counteracts human immunodeficiency virus type 1 restriction by various TRIM5 orthologues in a cell type-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Lv1 inhibition of human immunodeficiency virus type 1 is counteracted by factors that stimulate synthesis or nuclear translocation of viral cDNA

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

As(2)O(3) enhances retroviral reverse transcription and counteracts Ref1 antiviral activity

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Stable gene transfer to the nervous system using a non-primate lentiviral vector

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Role of HIV-2 envelope in Lv2-mediated restriction.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.40

7 January 2021

Identifiers

DOI

10.1038/GT.2010.40

1 reference

28 July 2017

1 reference