(Q33553780)

English

Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway.

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19776010%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway (English)

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19776010%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

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Fiona C McGillicuddy

1

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8 February 2020

5

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8 February 2020

6

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8 February 2020

Muredach P. Reilly

8

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8 February 2020

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Elise H Chiquoine

2

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8 February 2020

Christine C Hinkle

3

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8 February 2020

Roy J Kim

4

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8 February 2020

Emer M Smyth

7

1 reference

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8 February 2020

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publication date

23 September 2009

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8 February 2020

Journal of Biological Chemistry

1 reference

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8 February 2020

284

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8 February 2020

31936-31944

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8 February 2020

46

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Europe PubMed Central

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8 February 2020

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

1 reference

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Normalization of obesity-associated insulin resistance through immunotherapy

1 reference

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21 June 2018

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

1 reference

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21 June 2018

Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Interferon regulatory factors are transcriptional regulators of adipogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Adipokines: the missing link between insulin resistance and obesity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Regulation of interferon-gamma during innate and adaptive immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Obesity-induced inflammation: a metabolic dialogue in the language of inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

The interferon regulatory factor family in host defense: mechanism of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Macrophage-secreted factors induce adipocyte inflammation and insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Obesity is associated with macrophage accumulation in adipose tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Monocyte chemoattractant protein 1 in obesity and insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Suppressors of cytokine signalling (SOCS) in the immune system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Role of peroxisome proliferator-activated receptor-gamma in maintenance of the characteristics of mature 3T3-L1 adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Leptin activates Stat3, Stat1 and AP-1 in mouse adipose tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Obesity and insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Guanosine 5'-O-(3-thiotriphosphate) (GTPgammaS) stimulation of GLUT4 translocation is tyrosine kinase-dependent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

The IFN gamma receptor: a paradigm for cytokine receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Participation of JAK and STAT proteins in growth hormone-induced signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Tumor necrosis factor alpha inhibits signaling from the insulin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Tumor necrosis factor alpha: a key component of the obesity-diabetes link

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797265

21 June 2018

Diet induction of monocyte chemoattractant protein-1 and its impact on obesity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.061655

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The Jak-STAT pathway stimulated by interleukin 6.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.061655

21 January 2018

Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.061655

21 January 2018

Involvement of the IRF-1 transcription factor in antiviral responses to interferons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.061655

21 January 2018

Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.061655

21 January 2018

Preassembly and ligand-induced restructuring of the chains of the IFN-gamma receptor complex: the roles of Jak kinases, Stat1 and the receptor chains.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.061655

21 January 2018

Pomegranate flower: a unique traditional antidiabetic medicine with dual PPAR-alpha/-gamma activator properties

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.061655

21 January 2018

Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.061655

21 January 2018

Lineage-specific activation of STAT3 by interferon-gamma in human neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/19776010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship of serum interleukin-6 and tumor necrosis factor alpha levels with abdominal fat distribution evaluated by ultrasonography in overweight or obese postmenopausal women

1 reference

https://pubmed.ncbi.nlm.nih.gov/19776010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19776010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/19776010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exenatide prevents fat-induced insulin resistance and raises adiponectin expression and plasma levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/19776010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.061655

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19776010%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

release_jes3bbrkf5ehha45jd6nt4ugja

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https://api.fatcat.wiki/v0/release/jes3bbrkf5ehha45jd6nt4ugja

24 November 2022

based on heuristic

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19776010%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19776010%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

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