(Q33569648)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892704%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892704%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

0 references

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892704%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Marco Giorgio

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892704%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

author name string

Alexey A Tomilov

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892704%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Robert A Schoenfeld

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892704%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Enrica Migliaccio

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892704%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Jon J Ramsey

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892704%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Kevork Hagopian

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892704%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Pier Giuseppe Pelicci

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892704%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Gino A Cortopassi

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892704%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

language of work or name

English

0 references

publication date

5 November 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892704%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

11 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892704%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

volume

285

1 reference

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11 February 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892704%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

page(s)

1153-1165

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892704%20AND%20SRC:MED&resulttype=core&format=json

Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity in Drosophila

11 February 2020

cites work

1 reference

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The overexpression of major antioxidant enzymes does not extend the lifespan of mice

21 June 2018

1 reference

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Immunosenescence and immunogenetics of human longevity

21 June 2018

1 reference

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p66Shc-generated oxidative signal promotes fat accumulation

21 June 2018

1 reference

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Overexpression of glucose-6-phosphate dehydrogenase extends the life span of Drosophila melanogaster

21 June 2018

1 reference

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Aging and inflammation in two epidemiological worlds

21 June 2018

1 reference

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Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila

21 June 2018

1 reference

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Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice.

21 June 2018

1 reference

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New findings in gene knockout, mutant and transgenic mice

21 June 2018

1 reference

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Phosphatidylinositol 3-phosphate-dependent and -independent functions of p40phox in activation of the neutrophil NADPH oxidase

21 June 2018

1 reference

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A critical role of protein kinase C delta activation loop phosphorylation in formyl-methionyl-leucyl-phenylalanine-induced phosphorylation of p47(phox) and rapid activation of nicotinamide adenine dinucleotide phosphate oxidase

21 June 2018

1 reference

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A systems biology approach for pathway level analysis

21 June 2018

1 reference

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Induction of heme oxygenase-1 in vivo suppresses NADPH oxidase derived oxidative stress.

21 June 2018

1 reference

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Circulating blood leukocyte gene expression profiles: effects of the Ames dwarf mutation on pathways related to immunity and inflammation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine

21 June 2018

1 reference

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Anti-inflammatory mechanisms of dietary restriction in slowing aging processes

21 June 2018

1 reference

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PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

PKC delta phosphorylates p52ShcA at Ser29 to regulate ERK activation in response to H2O2.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Stress resistance in long-lived mouse models

21 June 2018

1 reference

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Structural basis of function in heterotrimeric G proteins

21 June 2018

1 reference

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Small-angle X-ray scattering reveals an extended organization for the autoinhibitory resting state of the p47(phox) modular protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

The Src family kinase, Lyn, is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters and growth factors which stimulate its association with numerous other signaling molecules

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Sos-mediated activation of rac1 by p66shc

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils

21 June 2018

1 reference

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Aging, longevity, inflammation, and cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Extension of murine life span by overexpression of catalase targeted to mitochondria

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Developmental origins of aging in brain and blood vessels: an overview

21 June 2018

1 reference

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Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians

21 June 2018

1 reference

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Fungal metabolite gliotoxin targets flavocytochrome b558 in the activation of the human neutrophil NADPH oxidase

21 June 2018

1 reference

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Inflammatory exposure and historical changes in human life-spans

21 June 2018

1 reference

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Onto-Tools: an ensemble of web-accessible, ontology-based tools for the functional design and interpretation of high-throughput gene expression experiments

21 June 2018

1 reference

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Fungal metabolite gliotoxin inhibits assembly of the human respiratory burst NADPH oxidase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Induction of heme oxygenase-1 inhibits NAD(P)H oxidase activity by down-regulating cytochrome b558 expression via the reduction of heme availability.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Regulation of the phagocyte respiratory burst by small GTP-binding proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Aging: a theory based on free radical and radiation chemistry

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Membrane binding mechanisms of the PX domains of NADPH oxidase p40phox and p47phox

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity

21 June 2018

1 reference

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Protein kinase C-delta is a negative regulator of antigen-induced mast cell degranulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

21 June 2018

1 reference

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Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA.

21 June 2018

1 reference

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Feature extraction and normalization algorithms for high-density oligonucleotide gene expression array data

21 June 2018

2 references

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21 June 2018

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The NADPH oxidase components p47(phox) and p40(phox) bind to moesin through their PX domain

21 January 2018

1 reference

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Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

21 June 2018

1 reference

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The p66shc adaptor protein controls oxidative stress response and life span in mammals

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Cryptic Rac-binding and p21(Cdc42Hs/Rac)-activated kinase phosphorylation sites of NADPH oxidase component p67(phox)

21 June 2018

1 reference

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Receptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or Gs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Lyn, a src-like tyrosine kinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Interactions between the components of the human NADPH oxidase: a review about the intrigues in the phox family.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane-targeted phosphoinositide 3-kinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Oxidative stress, caloric restriction, and aging

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Phosphorylation of the respiratory burst oxidase subunit p47phox as determined by two-dimensional phosphopeptide mapping. Phosphorylation by protein kinase C, protein kinase A, and a mitogen-activated protein kinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase.Shc adapter protein signaling complexes

21 June 2018

1 reference

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Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

21 June 2018

1 reference

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Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors

21 June 2018

1 reference

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Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Assembly of the neutrophil respiratory burst oxidase. Protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase components

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801244

p66Shc deletion confers vascular protection in advanced atherosclerosis in hypercholesterolemic apolipoprotein E knockout mice

21 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.017491

Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.017491

The Database of Interacting Proteins: 2004 update

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.017491

Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.017491

Regulation of human eosinophil NADPH oxidase activity: a central role for PKCdelta

21 January 2018

1 reference

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Akt Phosphorylates p47phoxand Mediates Respiratory Burst Activity in Human Neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.017491

Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.017491

Epidermal growth factor receptor phosphorylates protein kinase C {delta} at Tyr332 to form a trimeric complex with p66Shc in the H2O2-stimulated cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.017491

The p40phox and p47phox PX domains of NADPH oxidase target cell membranes via direct and indirect recruitment by phosphoinositides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.017491

Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.017491

Modulating longevity in Drosophila by over- and underexpression of glutamate-cysteine ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.017491

Genetic modification of prenatal lethality and dilated cardiomyopathy in Mn superoxide dismutase mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.017491

Deletion of p66shc gene protects against age-related endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.017491

Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.017491

Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.017491

Cyclin-dependent kinase inhibition limits glomerulonephritis and extends lifespan of mice with systemic lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.017491

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.017491

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.017491

Phosphorylation of the oxidase-related 48K phosphoprotein family in the unusual autosomal cytochrome-negative and X-linked cytochrome-positive types of chronic granulomatous disease

21 January 2018

1 reference

12 December 2020

Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis

1 reference

12 December 2020

The antimicrobial peptide parabutoporin competes with p47(phox) as a PKC-substrate and inhibits NADPH oxidase in human neutrophils

1 reference

12 December 2020

Fungal gliotoxin targets the onset of superoxide-generating NADPH oxidase of human neutrophils

1 reference

12 December 2020

Characterization of transgenic mice that overexpress both copper zinc superoxide dismutase and catalase

1 reference

12 December 2020

Phosphatidylinositol-3 kinase regulates p21ras activation during IgE-mediated stimulation of human basophils

1 reference

12 December 2020

The mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway is involved in formyl-methionyl-leucyl-phenylalanine-induced p47phox phosphorylation in human neutrophils

1 reference

12 December 2020

Activation of the mitogen-activated protein kinase pathway by fMet-leu-Phe in the absence of Lyn and tyrosine phosphorylation of SHC in transfected cells

1 reference

12 December 2020

Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress

1 reference

12 December 2020

Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M109.017491

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892704%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892704%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

19892704

1 reference