(Q33571121)

28 July 2017

title

Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA. (English)

1 reference

Mycobacterium tuberculosis

28 July 2017

main subject

0 references

author name string

Katherine A Rawls

1

1 reference

28 July 2017

P Therese Lang

2

1 reference

28 July 2017

Jun Takeuchi

3

1 reference

28 July 2017

Shinichi Imamura

4

1 reference

28 July 2017

Tyler D Baguley

5

1 reference

28 July 2017

Christoph Grundner

6

1 reference

28 July 2017

Tom Alber

7

1 reference

28 July 2017

Jonathan A Ellman

8

1 reference

28 July 2017

language of work or name

English

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publication date

25 October 2009

1 reference

Bioorganic & Medicinal Chemistry Letters

28 July 2017

published in

1 reference

28 July 2017

volume

19

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28 July 2017

issue

24

1 reference

28 July 2017

page(s)

6851-6854

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A balancing act: efflux/influx in mycobacterial drug resistance

28 July 2017

cites work

1 reference

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The therapeutic potential of phosphatase inhibitors

21 June 2018

1 reference

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DOCK 6: combining techniques to model RNA-small molecule complexes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

Protein tyrosine phosphatase PtpA is not required for Mycobacterium tuberculosis growth in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

Identification of a new class of nonpeptidic inhibitors of cruzain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

PTP1B as a drug target: recent developments in PTP1B inhibitor discovery

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

The drug binding site of human alpha1-acid glycoprotein: insight from induced circular dichroism and electronic absorption spectra

21 June 2018

1 reference

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Recent development of small molecular specific inhibitor of protein tyrosine phosphatase 1B.

21 June 2018

1 reference

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Multiple ligand-binding properties of the lipocalin member chicken alpha1-acid glycoprotein studied by circular dichroism and electronic absorption spectroscopy: the essential role of the conserved tryptophan residue

21 June 2018

1 reference

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Screening in a spirit haunted world

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

Substrate activity screening: a fragment-based method for the rapid identification of nonpeptidic protease inhibitors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment-based approach

21 June 2018

1 reference

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Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes.

21 June 2018

1 reference

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Crystal structure of low-molecular-weight protein tyrosine phosphatase from Mycobacterium tuberculosis at 1.9-A resolution

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

Protein tyrosine phosphatase: enzymatic assays

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

A specific mechanism of nonspecific inhibition

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

Expression and localization of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

Cloning and characterization of secretory tyrosine phosphatases of Mycobacterium tuberculosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

The Envelope of Mycobacteria

21 June 2018

1 reference

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Synthetic chalcones as efficient inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

Screening-based discovery and structural dissection of a novel family 18 chitinase inhibitor.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801607

Rapid identification of potent nonpeptidic serine protease inhibitors

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19889539

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BMCL.2009.10.090

1 reference

28 July 2017

1 reference

28 July 2017

1 reference