(Q33581824)

English

Cannabinoids Delta(9)-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NF-kappaB and interferon-beta/STAT proinflammatory pathways in BV-2 microglial cells

scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Cannabinoids Delta(9)-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NF-kappaB and interferon-beta/STAT proinflammatory pathways in BV-2 microglial cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

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lipopolysaccharide

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tetrahydrocannabinol

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microglial inhibitor

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1 reference

based on heuristic

inferred from title

author name string

Ewa Kozela

1

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Maciej Pietr

2

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Ana Juknat

3

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Neta Rimmerman

4

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Rivka Levy

5

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Zvi Vogel

6

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

language of work or name

0 references

publication date

12 November 2009

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

number of pages

11

1 reference

based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

285

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

1616-1626

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb

1 reference

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21 June 2018

Combined genome-wide expression profiling and targeted RNA interference in primary mouse macrophages reveals perturbation of transcriptional networks associated with interferon signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation

1 reference

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21 June 2018

Differential changes in GPR55 during microglial cell activation

1 reference

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21 June 2018

Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway

1 reference

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21 June 2018

Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

SOCS regulation of the JAK/STAT signalling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Ups and downs: the STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Cannabinoid receptors: where they are and what they do.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Cannabinoid-induced immune suppression and modulation of antigen-presenting cells

1 reference

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21 June 2018

CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration

1 reference

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21 June 2018

Cannabinoid control of neuroinflammation related to multiple sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Cannabidiol--recent advances

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Microglial activation and its implications in the brain diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Regulation of Toll-like receptor 4 expression and its signaling by hypoxia in cultured microglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Structure and function of Toll receptors and their ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

STAT activation and differential complex formation dictate selectivity of interferon responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Roles of glia-derived cytokines on neuronal degeneration and regeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

The negative regulatory roles of suppressor of cytokine signaling proteins in myeloid signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

STAT3: a potential therapeutic target in dendritic cells for the induction of transplant tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

New cannabidiol derivatives: synthesis, binding to cannabinoid receptor, and evaluation of their antiinflammatory activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Achieving stability of lipopolysaccharide-induced NF-kappaB activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

The synthetic cannabinoid R(+)WIN 55,212-2 inhibits the interleukin-1 signaling pathway in human astrocytes in a cannabinoid receptor-independent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Nonpsychotropic cannabinoid receptors regulate microglial cell migration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Mutational switch of an IL-6 response to an interferon-gamma-like response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Cannabinoid-receptor-independent cell signalling by N-acylethanolamines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

A new mathematical model for relative quantification in real-time RT-PCR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Roles of STAT3 defined by tissue-specific gene targeting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Delta9 tetrahydrocannabinol and cannabidiol alter cytokine production by human immune cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production by dexanabinol (HU-211), a nonpsychotropic cannabinoid.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Attenuation of inducible nitric oxide synthase gene expression by delta 9-tetrahydrocannabinol is mediated through the inhibition of nuclear factor- kappa B/Rel activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

The perturbation of model membranes by (-)-delta 9-tetrahydrocannabinol. Studies using solid-state 2H- and 13C-NMR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus

1 reference

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21 June 2018

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

An immortalized cell line expresses properties of activated microglial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Cannabinoid agonists stimulate both receptor- and non-receptor-mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

21 June 2018

Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069294

21 January 2018

Chronic exposure to Delta9-tetrahydrocannabinol downregulates oxytocin and oxytocin-associated neurophysin in specific brain areas

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069294

21 January 2018

Arachidonylcyclopropylamide increases microglial cell migration through cannabinoid CB2 and abnormal-cannabidiol-sensitive receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069294

21 January 2018

Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069294

21 January 2018

Cannabinoid-mediated inhibition of inducible nitric oxide production by rat microglial cells: evidence for CB1 receptor participation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069294

21 January 2018

(-)-Delta9-tetrahydrocannabinol antagonizes the peripheral cannabinoid receptor-mediated inhibition of adenylyl cyclase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069294

21 January 2018

Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069294

21 January 2018

In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069294

21 January 2018

CB1 cannabinoid receptors are involved in neuroprotection via NF-kappa B inhibition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069294

21 January 2018

IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069294

21 January 2018

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069294

21 January 2018

Alternative activation of STAT1 and STAT3 in response to interferon-gamma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069294

21 January 2018

Cutting edge: role of STAT1, STAT3, and STAT5 in IFN-alpha beta responses in T lymphocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069294

21 January 2018

Stat3 in resident macrophages as a repressor protein of inflammatory response

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069294

21 January 2018

Global identification and comparative analysis of SOCS genes in fish: insights into the molecular evolution of SOCS family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069294

21 January 2018

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069294

21 January 2018

An RNA-binding protein alphaCP-1 is involved in the STAT3-mediated suppression of NF-kappaB transcriptional activity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069294

21 January 2018

Cannabinoids inhibit LPS-inducible cytokine mRNA expression in rat microglial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

31 October 2018

Comparative receptor binding analyses of cannabinoid agonists and antagonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804319

31 October 2018

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19910459

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Marijuana components stimulate human peripheral blood mononuclear cell secretion of interferon-gamma and suppress interleukin-1 alpha in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19910459

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STAT3-mediated anti-inflammatory signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/19910459

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local administration of WIN 55,212-2 reduces chronic granuloma-associated angiogenesis in rat by inhibiting NF-κB activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19910459

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cannabinol-mediated inhibition of nuclear factor-kappaB, cAMP response element-binding protein, and interleukin-2 secretion by activated thymocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19910459

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin-10 in endotoxemic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19910459

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.069294

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

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