(Q33590455)

28 July 2017

1 reference

title

Leptin: in search of role(s) in human physiology and pathophysiology (English)

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28 July 2017

1 reference

Mantzoros CS

1

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28 July 2017

Moschos SJ

series ordinal

2

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28 July 2017

publication date

1 November 1998

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28 July 2017

published in

Clinical Endocrinology

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28 July 2017

volume

49

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28 July 2017

issue

5

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28 July 2017

page(s)

551-567

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Role of leptin in the neuroendocrine response to fasting

28 July 2017

cites work

1 reference

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Metabolic implications of body fat distribution

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Effect of fasting on serum leptin in normal human subjects.

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Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: leptin inhibits cortisol release directly

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Leptin: the tale of an obesity gene

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Regulation of in vivo growth hormone secretion by leptin

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Presence of leptin in colostrum and/or breast milk from lactating mothers: a potential role in the regulation of neonatal food intake

21 January 2018

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Circulating leptin concentrations in polycystic ovary syndrome: relation to anthropometric and metabolic parameters.

21 January 2018

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Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

21 January 2018

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Indication for linkage of the human OB gene region with extreme obesity

21 January 2018

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A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

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Modulation of insulin activities by leptin

21 January 2018

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Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity

21 January 2018

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Mutation screening and identification of a sequence variation in the human ob gene coding region

21 January 2018

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Serum immunoreactive-leptin concentrations in normal-weight and obese humans

21 January 2018

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Stimulation of corticotrophin-releasing hormone release by the obese (ob) gene product, leptin, from hypothalamic explants.

21 January 2018

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Plasma leptin and insulin relationships in obese and nonobese humans.

21 January 2018

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Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma

21 January 2018

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Plasma leptin in depressed patients and healthy controls.

21 January 2018

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Leptin: a significant indicator of total body fat but not of visceral fat and insulin insensitivity in African-American women

21 January 2018

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Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion

21 January 2018

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Serum leptin concentrations in patients with anorexia nervosa, bulimia nervosa and non-specific eating disorders correlate with the body mass index but are independent of the respective disease

21 January 2018

1 reference

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Leptin expression and action: new experimental paradigms

21 January 2018

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Obesity and the hypothalamus: novel peptides for new pathways

21 January 2018

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Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

The alphabet of weight control

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Menstrual Cycles: Fatness as a Determinant of Minimum Weight for Height Necessary for Their Maintenance or Onset

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Role of the beta3-adrenoceptor in the control of leptin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Genomic structure and promoter analysis of the human obese gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

In vivo effects of leptin-related synthetic peptides on body weight and food intake in female ob/ob mice: localization of leptin activity to domains between amino acid residues 106-140.

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters

21 January 2018

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Leptin concentrations in diabetic and nondiabetic Mexican-Americans

21 January 2018

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The mouse obese gene. Genomic organization, promoter activity, and activation by CCAAT/enhancer-binding protein alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Leptin levels in patients with anorexia nervosa are reduced in the acute stage and elevated upon short-term weight restoration

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Physiological effects of CNTF-induced wasting

21 January 2018

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The effects of lesions in the hypothalamus in parabiotic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Evidence for leptin binding to proteins in serum of rodents and humans: modulation with obesity

21 January 2018

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Carbohydrate intake and short-term regulation of leptin in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Serum leptin and short-term regulation of eating in obese women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

The role of depot fat in the hypothalamic control of food intake in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

High leptin concentrations in serum of very obese children are further stimulated by dexamethasone

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Responses of leptin to short-term fasting and refeeding in humans: a link with ketogenesis but not ketones themselves

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Low leptin levels predict amenorrhea in underweight and eating disordered females

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

beta-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Circulating leptin in normal children and during the dynamic phase of juvenile obesity: relation to body fatness, energy metabolism, caloric intake, and sexual dimorphism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Prolonged exercise decreases serum leptin concentrations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Plasma leptin levels correlate to islet function independently of body fat in postmenopausal women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Hypoleptinemia in women athletes: absence of a diurnal rhythm with amenorrhea

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Abnormal splicing of the leptin receptor in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Leptin inhibits glycogen synthesis in the isolated soleus muscle of obese (ob/ob) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Overexpression of the obese (ob) gene in adipose tissue of human obese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Leptin secretion from adipose tissue in women. Relationship to plasma levels and gene expression

21 January 2018

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A pathogenic role of visceral fat beta 3-adrenoceptors in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice

21 January 2018

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Absence of mutations in the human OB gene in obese/diabetic subjects

21 January 2018

1 reference

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Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM.

21 January 2018

1 reference

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Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice.

21 January 2018

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Effect of birth weight and maternal smoking on cord blood leptin concentrations of full-term and preterm newborns

21 January 2018

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Zinc may regulate serum leptin concentrations in humans

21 January 2018

1 reference

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Circulating insulin concentrations, smoking, and alcohol intake are important independent predictors of leptin in young healthy men.

21 January 2018

1 reference

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Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations

21 January 2018

1 reference

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Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue

21 January 2018

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Serum leptin concentration in cord blood: relationship to birth weight and gender

21 January 2018

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Radiommunological measurement of leptin in plasma of obese and diabetic human subjects

21 January 2018

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Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Congenital leptin deficiency is associated with severe early-onset obesity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Leptin impairs metabolic actions of insulin in isolated rat adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

A short form of leptin receptor performs signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Gender differences in the response of plasma leptin concentrations to weight loss in obese older individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Daily energy expenditure is related to plasma leptin concentrations in older African-American women but not men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Human obese gene: molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Effect of troglitazone on leptin production. Studies in vitro and in human subjects

21 January 2018

1 reference

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Increased circulating leptin concentrations in insulin-resistant first-degree relatives of patients with non-insulin-dependent diabetes mellitus: relationship to body composition and insulin sensitivity but not to family history of non-insulin-depen

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Effects of the obese gene product on body weight regulation in ob/ob mice

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Serum leptin in normal-weight and obese humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Effects of acute hyperinsulinemia on plasma leptin concentrations in insulin-sensitive and insulin-resistant Pima Indians.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Relatively low plasma leptin concentrations precede weight gain in Pima Indians

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Extreme obesity may be linked to markers flanking the human OB gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Is leptin an insulin counter-regulatory hormone?

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Regulation of ob gene mRNA levels in cultured adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Obesity, leptin, and the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Relation between plasma leptin levels and measures of body fat in identical twins discordant for obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Serum leptin concentrations in women with polycystic ovary syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Transient increase in obese gene expression after food intake or insulin administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Total energy expenditure and the level of physical activity correlate with plasma leptin concentrations in five-year-old children

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Effect of diet composition on leptin concentration in lean subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Leptin concentrations in amniotic fluid, venous and arterial cord blood and maternal serum: high leptin synthesis in the fetus and inverse correlation with placental weight

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Levels of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Estrogen increases in vivo leptin production in rats and human subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Ultradian oscillations of leptin secretion in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Leptin is present in human cord blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Effects of leptin on insulin sensitivity in normal rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

21 January 2018

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A family of phospholipid autacoids: occurrence, metabolism and bioactions

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Leptin: its role in obesity and beyond

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

A role for glucagon-like peptide-1 in the central regulation of feeding

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Obesity results as a consequence of glucocorticoid induced leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Supraphysiological hyperinsulinemia increases plasma leptin concentrations after 4 h in normal subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Leptin: a trigger for puberty?

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Insulin and cortisol promote leptin production in cultured human fat cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Leptin receptor action in hepatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Effect of Fasting, Refeeding, and Dietary Fat Restriction on Plasma Leptin Levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Leptin activation in hypothalamus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Serum leptin concentrations in human immunodeficiency virus-infected men with low adiposity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Regulation of expression of leptin mRNA and secretion of leptin by thyroid hormone in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Role of leptin in hypothalamic-pituitary function

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Direct intraovarian effects of leptin: impairment of the synergistic action of insulin-like growth factor-I on follicle-stimulating hormone-dependent estradiol-17 beta production by rat ovarian granulosa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Glucocorticoids as counterregulatory hormones of leptin: toward an understanding of leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Crystal structure of the obese protein leptin-E100

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Positional cloning of the mouse obese gene and its human homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Serum leptin concentration, obesity, and insulin resistance in Western Samoans: cross sectional study

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Effects of gender, body composition, and menopause on plasma concentrations of leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

Acute stimulation of glucose metabolism in mice by leptin treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2265.1998.00571.X

10.1046/J.1365-2265.1998.00571.X

21 January 2018

Identifiers

DOI

1 reference

28 July 2017

1 reference