(Q33603071)

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Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein

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Europe PubMed Central

PubMed publication ID

28 July 2017

Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein (English)

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Europe PubMed Central

PubMed publication ID

28 July 2017

author name string

G Kaur

1

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

M Pawlik

2

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Europe PubMed Central

PubMed publication ID

28 July 2017

S E Gandy

3

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

M E Ehrlich

4

1 reference

Europe PubMed Central

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28 July 2017

J F Smiley

5

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Europe PubMed Central

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28 July 2017

E Levy

6

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28 July 2017

language of work or name

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publication date

25 October 2016

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Europe PubMed Central

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28 July 2017

Molecular Psychiatry

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Europe PubMed Central

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28 July 2017

22

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Europe PubMed Central

PubMed publication ID

28 July 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

981-989

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Europe PubMed Central

PubMed publication ID

28 July 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5405008/fullTextXML

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inferred from PubMed Central ID database lookup

https://scigraph.springernature.com/pub.10.1038/mp.2016.189

0 references

Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes

1 reference

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The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

1 reference

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Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF.

1 reference

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21 June 2018

Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease

1 reference

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Regional and sub-regional differences in hippocampal GABAergic neuronal vulnerability in the TgCRND8 mouse model of Alzheimer's disease

1 reference

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Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology

1 reference

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21 June 2018

Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer's disease.

1 reference

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Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ.

1 reference

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Altered synaptic structure in the hippocampus in a mouse model of Alzheimer's disease with soluble amyloid-β oligomers and no plaque pathology

1 reference

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The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes

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Glutamatergic transmission aberration: a major cause of behavioral deficits in a murine model of Down's syndrome.

1 reference

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Accumulation of amyloid-like Aβ1-42 in AEL (autophagy-endosomal-lysosomal) vesicles: potential implications for plaque biogenesis

1 reference

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21 June 2018

Early endosomal abnormalities and cholinergic neuron degeneration in amyloid-β protein precursor transgenic mice

1 reference

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21 June 2018

The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease

1 reference

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21 June 2018

The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus

1 reference

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Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain

1 reference

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Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia

1 reference

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Inhibition of choline acetyltransferase as a mechanism for cholinergic dysfunction induced by amyloid-β peptide oligomers.

1 reference

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21 June 2018

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia

1 reference

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21 June 2018

Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice

1 reference

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21 June 2018

Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5405008

21 June 2018

Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5405008

21 June 2018

The basal forebrain cholinergic system in aging and dementia. Rescuing cholinergic neurons from neurotoxic amyloid-β42 with memantine

1 reference

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21 June 2018

Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.

1 reference

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21 June 2018

The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases

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21 June 2018

A beta oligomers - a decade of discovery

1 reference

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21 June 2018

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

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1 reference

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Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.

1 reference

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Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction.

1 reference

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21 June 2018

Amyloid beta peptides and central cholinergic neurons: functional interrelationship and relevance to Alzheimer's disease pathology

1 reference

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Cholinergic neuropathology in a mouse model of Alzheimer's disease

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments

1 reference

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1 reference

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1 reference

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A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

1 reference

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21 June 2018

Alpha synuclein in neurodegenerative disorders: murderer or accomplice?

1 reference

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Alzheimer's disease: a re-examination of the amyloid hypothesis

1 reference

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1 reference

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21 June 2018

Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the beta-amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5405008

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Hereditary cerebral haemorrhage with amyloidosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5405008

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Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5405008

21 June 2018

Brain amyloid in normal aging and cerebral amyloid angiopathy is antigenically related to Alzheimer's disease beta-protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5405008

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Differences between vascular and plaque core amyloid in Alzheimer's disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5405008

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Hereditary cerebral haemorrhage caused by cortical amyloid angiopathy.

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21 June 2018

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

1 reference

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21 June 2018

Dementia in hereditary cerebral hemorrhage with amyloidosis-Dutch type.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5405008

21 June 2018

Hereditary cerebral hemorrhage with amyloidosis-Dutch type. Clinical and computed tomographic analysis of 24 cases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5405008

21 June 2018

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5405008

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5405008

21 June 2018

Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5405008

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Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein

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21 June 2018

Familial cerebral amyloid angiopathy presenting as recurrent cerebral haemorrhage.

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https://api.crossref.org/works/10.1038%2FMP.2016.189

21 January 2018

Hereditary cerebral haemorrhage with amyloidosis--Dutch type. Magnetic resonance imaging findings in 7 cases.

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.189

21 January 2018

Mutation frequency of PRKAR1B and the major familial dementia genes in a Dutch early onset dementia cohort.

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.189

21 January 2018

A short cytoplasmic domain of the amyloid precursor protein induces apoptosis in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.189

21 January 2018

beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.189

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Cortical thickness, neuron density and size in the inferior parietal lobe in schizophrenia

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https://api.crossref.org/works/10.1038%2FMP.2016.189

21 January 2018

Analysis of cholinergic markers, biogenic amines, and amino acids in the CNS of two APP overexpression mouse models

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.189

21 January 2018

Impairment of cholinergic neurotransmission in adult and aged transgenic Tg2576 mouse brain expressing the Swedish mutation of human beta-amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.189

21 January 2018

Intracellular Aß triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.189

21 January 2018

Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.189

21 January 2018

Accelerated aging of the GABAergic septohippocampal pathway and decreased hippocampal rhythms in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.189

21 January 2018

βCTF-correlated burst of hippocampal TNFα occurs at a very early, pre-plaque stage in the TgCRND8 mouse model of Alzheimer's disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5405008

30 October 2018

Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5405008

30 October 2018

Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5405008

30 October 2018

C-terminal fragment of amyloid precursor protein induces astrocytosis

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https://pubmed.ncbi.nlm.nih.gov/27777419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hereditary cerebral hemorrhage with amyloidosis--Dutch type. Research-Group Hereditary Cerebral Amyloid-Angiopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/27777419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/MP.2016.189

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

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