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Molecular mechanisms of action of bisphosphonates.
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1 reference
stated in
Europe PubMed Central
PubMed publication ID
10321934
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
review article
1 reference
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Europe PubMed Central
title
Molecular mechanisms of action of bisphosphonates
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10321934
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
author
Michael J. Rogers
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10321934
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
Robert Graham G Russell
series ordinal
9
1 reference
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Europe PubMed Central
PubMed publication ID
10321934
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
author name string
J C Frith
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2
1 reference
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Europe PubMed Central
PubMed publication ID
10321934
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
S P Luckman
series ordinal
3
1 reference
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Europe PubMed Central
PubMed publication ID
10321934
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
F P Coxon
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10321934
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
H L Benford
series ordinal
5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10321934
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
J Mönkkönen
series ordinal
6
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10321934
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
S Auriola
series ordinal
7
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10321934
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
K M Chilton
series ordinal
8
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10321934
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
publication date
1 May 1999
1 reference
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Europe PubMed Central
PubMed publication ID
10321934
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
published in
Bone
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10321934
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
volume
24
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10321934
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
issue
5 Suppl
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10321934
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
page(s)
73S-79S
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10321934
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
cites work
The acute-phase response after bisphosphonate administration
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7 January 2021
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Identification of adenine nucleotide-containing metabolites of bisphosphonate drugs using ion-pair liquid chromatography-electrospray mass spectrometry.
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Crossref
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7 January 2021
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Alendronate distributed on bone surfaces inhibits osteoclastic bone resorption in vitro and in experimental hypercalcemia models
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7 January 2021
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Bisphosphonates directly inhibit the bone resorption activity of isolated avian osteoclasts in vitro
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
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7 January 2021
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The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
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7 January 2021
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The management of Paget's disease of bone
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Crossref
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https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
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7 January 2021
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Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates
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Crossref
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7 January 2021
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The effect of several diphosphonates on acid phosphohydrolases and other lysosomal enzymes
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Crossref
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https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
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7 January 2021
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Dichloromethylenebisphosphonate (Cl2MBP) inhibits bone resorption through injury to osteoclasts that resorb Cl2MBP-coated bone
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
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7 January 2021
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Bisphosphonates. Pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone disease
1 reference
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reference URL
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7 January 2021
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The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
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7 January 2021
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Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
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7 January 2021
based on heuristic
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Effect of pyrophosphate on hydroxyapatite and its implications in calcium homeostasis
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Crossref
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https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
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7 January 2021
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Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow.
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of four bisphosphonates on bone resorption, lysosomal enzyme release, protein synthesis and mitotic activities in mouse calvarial bones in vitro
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
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7 January 2021
based on heuristic
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Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study Group.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Migration and phenotypic transformation of osteoclast precursors into mature osteoclasts: the effect of a bisphosphonate.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein prenylation: a mediator of protein-protein interactions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of the distribution of 3H-alendronate and 3H-etidronate in rat and mouse bones
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of tiludronate and ibandronate on the secretion of proinflammatory cytokines and nitric oxide from macrophages in vitro.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
A possible mechanism of the specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled borders
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tiludronate inhibits protein tyrosine phosphatase activity in osteoclasts.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Contrast between effects of aminobisphosphonates and non-aminobisphosphonates on collagen-induced arthritis in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bisphosphonates act on osteoblastic cells and inhibit osteoclast formation in mouse marrow cultures.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conversion from farnesyl diphosphate synthase to geranylgeranyl diphosphate synthase by random chemical mutagenesis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Alendronate inhibition of protein-tyrosine-phosphatase-meg1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Application of an in vitro model and a clinical protocol in the assessment of the potency of a new bisphosphonate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of liposomal and free bisphosphonates on the IL-1 beta, IL-6 and TNF alpha secretion from RAW 264 cells in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bisphosphonates are incorporated into adenine nucleotides by human aminoacyl-tRNA synthetase enzymes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Incorporation of bisphosphonates into adenine nucleotides by amoebae of the cellular slime mould Dictyostelium discoideum.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metabolism of halogenated bisphosphonates by the cellular slime mould dictyostelium discoideum
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitory effects of bisphosphonates on growth of amoebae of the cellular slime mold Dictyostelium discoideum
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of growth of Dictyostelium discoideum amoebae by bisphosphonate drugs is dependent on cellular uptake
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The influence of pyrophosphate, condensed phosphates, phosphonates and other phosphate compounds on the dissolution of hydroxyapatite in vitro and on bone resorption induced by parathyroid hormone in tissue culture and in thyroparathyroidectomised r
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bisphosphonates act on rat bone resorption through the mediation of osteoblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-6 and tumor necrosis factor alpha levels after bisphosphonates treatment in vitro and in patients with malignancy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Quantitative morphometric evaluation of the inhibitory activity of new aminobisphosphonates on bone resorption in the rat.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (Cl 2 MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-6 and the acute phase response during treatment of patients with Paget's disease with the nitrogen-containing bisphosphonate dimethylaminohydroxypropylidene bisphosphonate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure-activity relationships of various bisphosphonates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti-tumour activity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Diphosphonates and Page's disease of bone.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of osteoclast function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural requirements for bisphosphonate actions in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bisphosphonates induce osteoblasts to secrete an inhibitor of osteoclast-mediated resorption
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction between effects of parathyroid hormone and bisphosphonate on regulation of osteoclast activity by the osteoblast-like cell line UMR-106.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rab GTPases in vesicular transport
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein prenylation: molecular mechanisms and functional consequences
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acid extrusion is induced by osteoclast attachment to bone. Inhibition by alendronate and calcitonin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S8756-3282(99)00070-8
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10321934
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
PubMed publication ID
10321934
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10321934
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
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