(Q33635242)

28 July 2017

title

Early safety assessment using cellular systems biology yields insights into mechanisms of action (English)

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28 July 2017

Kenneth A Giuliano

1

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28 July 2017

Albert H Gough

2

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28 July 2017

D Lansing Taylor

3

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28 July 2017

Lawrence A Vernetti

4

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28 July 2017

Patricia A Johnston

5

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28 July 2017

publication date

16 July 2010

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Journal of Biomolecular Screening

28 July 2017

published in

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28 July 2017

volume

15

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28 July 2017

issue

7

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28 July 2017

page(s)

783-797

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High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

28 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1177%2F1087057110376413

Cellular imaging predictions of clinical drug-induced liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110376413

Systems cell biology knowledge created from high content screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110376413

What keeps cells in tissues behaving normally in the face of myriad mutations?

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057110376413

High-content screening with siRNA optimizes a cell biological approach to drug discovery: defining the role of P53 activation in the cellular response to anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110376413

Multidimensional drug profiling by automated microscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110376413

Cellular heterogeneity: do differences make a difference?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110376413

Hepatocytes--the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110376413

Mitochondrial Membrane Potential: Evidence from Studies with a Fluorescent Probe

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110376413

Regional loss of the mitochondrial membrane potential in the hepatocyte is rapidly followed by externalization of phosphatidylserines at that specific site during apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110376413

Membrane potential greatly enhances superoxide generation by the cytochrome bc1 complex reconstituted into phospholipid vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110376413

In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110376413

Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110376413

Clinical pharmacokinetics of nefazodone

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110376413

The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110376413

Effects of chlorpromazine on plasma membrane permeability and fluidity in the rat brain: a dynamic positron autoradiography and fluorescence polarization study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110376413

21 January 2018

Identifiers

DOI

10.1177/1087057110376413

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28 July 2017

1 reference