(Q33642693)

28 July 2017

title

Ligand dissociation from estrogen receptor is mediated by receptor dimerization: evidence from molecular dynamics simulations (English)

1 reference

28 July 2017

Milton T Sonoda

1

1 reference

28 July 2017

Leandro Martínez

2

1 reference

28 July 2017

Paul Webb

3

1 reference

28 July 2017

Munir S Skaf

4

1 reference

28 July 2017

Igor Polikarpov

5

1 reference

28 July 2017

publication date

10 April 2008

1 reference

28 July 2017

published in

Molecular Endocrinology

1 reference

28 July 2017

volume

22

1 reference

28 July 2017

issue

7

1 reference

28 July 2017

page(s)

1565-1578

1 reference

X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation

28 July 2017

cites work

1 reference

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21 June 2018

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Scalable molecular dynamics with NAMD

21 June 2018

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Molecular dynamics simulations reveal multiple pathways of ligand dissociation from thyroid hormone receptors

21 June 2018

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Ligand control of coregulator recruitment to nuclear receptors

21 June 2018

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21 June 2018

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21 June 2018

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Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha

21 June 2018

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The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway

21 June 2018

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The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism

21 June 2018

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Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 2. Clinical considerations and new agents

21 June 2018

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Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 1. Receptor interactions

21 June 2018

1 reference

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Mutations of tyrosine 537 in the human estrogen receptor-alpha selectively alter the receptor's affinity for estradiol and the kinetics of the interaction

21 June 2018

1 reference

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Cavities and packing defects in the structural dynamics of myoglobin

21 June 2018

1 reference

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Nuclear hormone receptors and gene expression

21 June 2018

1 reference

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Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Estrogen receptor transcription and transactivation: Basic aspects of estrogen action

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Probing conformational changes in the estrogen receptor: evidence for a partially unfolded intermediate facilitating ligand binding and release

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Definition of the surface in the thyroid hormone receptor ligand binding domain for association as homodimers and heterodimers with retinoid X receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Estrogen receptors: how do they control reproductive and nonreproductive functions?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Estrogen receptor domains E and F: role in dimerization and interaction with coactivator RIP-140.

21 June 2018

1 reference

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Unbinding of retinoic acid from its receptor studied by steered molecular dynamics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Atomic structure of progesterone complexed with its receptor

21 June 2018

1 reference

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Altered ligand binding properties and enhanced stability of a constitutively active estrogen receptor: evidence that an open pocket conformation is required for ligand interaction.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Identification of amino acids in the hormone binding domain of the human estrogen receptor important in estrogen binding

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Comparative protein modelling by satisfaction of spatial restraints

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

A structural role for hormone in the thyroid hormone receptor.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

The carboxy-terminal F domain of the human estrogen receptor: role in the transcriptional activity of the receptor and the effectiveness of antiestrogens as estrogen antagonists

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Distal pocket residues affect picosecond ligand recombination in myoglobin. An experimental and molecular dynamics study of position 29 mutants

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Estradiol-binding kinetics of the activated and nonactivated estrogen receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Understanding the human estrogen receptor-alpha using targeted mutagenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Molecular dynamics simulations of ligand dissociation from thyroid hormone receptors: evidence of the likeliest escape pathway and its implications for the design of novel ligands

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Structural basis for the cell-specific activities of the NGFI-B and the Nurr1 ligand-binding domain

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Coactivator proteins as determinants of estrogen receptor structure and function: spectroscopic evidence for a novel coactivator-stabilized receptor conformation

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Estrogen receptor dimerization: ligand binding regulates dimer affinity and dimer dissociation rate

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Mapping the pathways for O2 entry into and exit from myoglobin.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

The nuclear receptor ligand-binding domain: structure and function

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Identification of Regions within the F Domain of the Human Estrogen Receptor α that Are Important for Modulating Transactivation and Protein-Protein Interactions

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5419439

Molecular sensors of estrogen receptor conformations and dynamics

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18403716

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Retinoic acid receptor: a simulation analysis of retinoic acid binding and the resulting conformational changes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18403716

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Coactivator peptides have a differential stabilizing effect on the binding of estrogens and antiestrogens with the estrogen receptor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18403716

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1210/ME.2007-0501

1 reference

28 July 2017

1 reference

28 July 2017

1 reference