(Q336500)

Helix-loop-helix DNA-binding domain superfamily

1 reference

MiT/TFE transcription factors, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

MiT/TFE transcription factors, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

MITF protein.png
1,920 × 975; 382 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

DNA-binding transcription repressor activity, RNA polymerase II-specific

1 reference

8 April 2019

Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

DNA-binding transcription activator activity, RNA polymerase II-specific

NAS

8 references

10 September 2018

STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75030&geneProductId=UniProtKB:O75030

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75030&geneProductId=UniProtKB:O75030

10 September 2018

SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75030&geneProductId=UniProtKB:O75030

10 September 2018

STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75030&geneProductId=UniProtKB:O75030

8 April 2019

STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75030&geneProductId=UniProtKB:O75030

DNA-binding transcription factor activity, RNA polymerase II-specific

4 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

6 references

8 April 2019

Molecular cloning of cDNA encoding a novel microphthalmia-associated transcription factor isoform with a distinct amino-terminus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in retinal pigment epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

Biallelic Mutations in MITF Cause Coloboma, Osteopetrosis, Microphthalmia, Macrocephaly, Albinism, and Deafness

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

protein-containing complex

1 reference

8 April 2019

SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

regulation of RNA biosynthetic process

biological process

1 reference

8 April 2019

MITF mediates cAMP-induced protein kinase C-beta expression in human melanocytes

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

positive regulation of DNA-templated transcription, initiation

IMP

2 references

8 April 2019

Functional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genes

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

Involvement of microphthalmia-associated transcription factor (MITF) in expression of human melanocortin-1 receptor (MC1R)

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

transcription, DNA-templated

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

multicellular organism development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

positive regulation of gene expression

3 references

8 April 2019

Microphthalmia-associated transcription factor (MITF) promotes differentiation of human retinal pigment epithelium (RPE) by regulating microRNAs-204/211 expression

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

HERC2 rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long-range enhancer and the OCA2 promoter

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

HERC2 rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long-range enhancer and the OCA2 promoter

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

transcription by RNA polymerase II

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75030&geneProductId=UniProtKB:O75030

regulation of transcription, DNA-templated

5 references

8 April 2019

Molecular cloning of cDNA encoding a novel microphthalmia-associated transcription factor isoform with a distinct amino-terminus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in retinal pigment epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

Biallelic Mutations in MITF Cause Coloboma, Osteopetrosis, Microphthalmia, Macrocephaly, Albinism, and Deafness

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

Wnt signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

osteoclast differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

melanocyte differentiation

3 references

8 April 2019

Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in retinal pigment epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

regulation of cell population proliferation

IBA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

camera-type eye development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

negative regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

canonical Wnt signaling pathway involved in negative regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

regulation of osteoclast differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

positive regulation of transcription, DNA-templated

3 references

8 April 2019

Molecular cloning of cDNA encoding a novel microphthalmia-associated transcription factor isoform with a distinct amino-terminus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in retinal pigment epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

positive regulation of transcription by RNA polymerase II

4 references

8 April 2019

STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

8 April 2019

Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

protein-containing complex assembly

1 reference

8 April 2019

SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

negative regulation of cell migration

1 reference

8 April 2019

Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75030

http://purl.uniprot.org/uniprot/O75030

IMP

Gene Atlas image

PBB GE MITF 207233 s at fs.png
732 × 530; 11 KB

0 references

exact match

1 reference

Myc-type, basic helix-loop-helix (bHLH) domain

Identifiers.org

has part(s)

1 reference

MiT/TFE transcription factors, N-terminal

1 reference

MiT/TFE transcription factors, C-terminal

1 reference