(Q33662727)

28 July 2017

title

RNAi phenotype profiling of kinases identifies potential therapeutic targets in Ewing's sarcoma (English)

1 reference

28 July 2017

1 reference

Shilpi Arora

1

1 reference

28 July 2017

Irma M Gonzales

2

1 reference

28 July 2017

R Tanner Hagelstrom

3

1 reference

28 July 2017

Christian Beaudry

4

1 reference

28 July 2017

Ashish Choudhary

5

1 reference

28 July 2017

Chao Sima

6

1 reference

28 July 2017

Raoul Tibes

7

1 reference

28 July 2017

Spyro Mousses

8

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28 July 2017

David O Azorsa

9

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28 July 2017

publication date

18 August 2010

1 reference

28 July 2017

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28 July 2017

volume

9

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28 July 2017

page(s)

218

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Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas

28 July 2017

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21 June 2018

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21 June 2018

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GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Stable interference of EWS-FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target

21 June 2018

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Morphoproteomic confirmation of constitutively activated mTOR, ERK, and NF-kappaB pathways in Ewing family of tumors.

21 June 2018

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A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies

21 June 2018

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EWS-Fli1 up-regulates expression of the Aurora A and Aurora B kinases.

21 June 2018

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Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells

21 June 2018

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Kinase requirements in human cells: IV. Differential kinase requirements in cervical and renal human tumor cell lines

21 June 2018

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Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen

21 June 2018

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Kinase requirements in human cells: I. Comparing kinase requirements across various cell types

21 June 2018

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Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future

21 June 2018

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Inhibition of PKCalpha activation in human bone and soft tissue sarcoma cells by the selective PKC inhibitor PKC412.

21 June 2018

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TNK2 preserves epidermal growth factor receptor expression on the cell surface and enhances migration and invasion of human breast cancer cells

21 June 2018

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Proliferation of Ewing sarcoma cell lines is suppressed by the receptor tyrosine kinase inhibitors gefitinib and vandetanib

21 June 2018

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Synthetic lethal screen identification of chemosensitizer loci in cancer cells

21 June 2018

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Novel therapeutic approaches in pediatric and young adult sarcomas

21 June 2018

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Mitotic kinases: the key to duplication, segregation, and cytokinesis errors, chromosomal instability, and oncogenesis

21 June 2018

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Gene expression profiling of human sarcomas: insights into sarcoma biology

21 June 2018

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EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933621

PI3K/AKT is involved in mediating survival signals that rescue Ewing tumour cells from fibroblast growth factor 2-induced cell death

21 June 2018

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Pediatric malignancies provide unique cancer therapy targets

21 June 2018

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Polo-like kinases (Plks) and cancer

21 June 2018

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21 June 2018

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RNA interference for the identification of disease-associated genes.

21 June 2018

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Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue

21 June 2018

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21 June 2018

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21 June 2018

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Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas

21 June 2018

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Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues

21 June 2018

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Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933621

LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933621

Tyrosine phosphorylation of ACK in response to temperature shift-down, hyperosmotic shock, and epidermal growth factor stimulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933621

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933621

GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933621

Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933621

The Biology of Ewing sarcoma.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933621

Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933621

Treatment of metastatic Ewing's sarcoma or primitive neuroectodermal tumor of bone: evaluation of combination ifosfamide and etoposide--a Children's Cancer Group and Pediatric Oncology Group study

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933621

Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933621

Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933621

Immunohistochemical detection of EWS and FLI-1 proteinss in Ewing sarcoma and primitive neuroectodermal tumors: comparative analysis with CD99 (MIC-2) expression.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933621

CD99 engagement: an effective therapeutic strategy for Ewing tumors

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933621

EWS-FLI1 and EWS-ERG gene fusions are associated with similar clinical phenotypes in Ewing's sarcoma.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933621

Silencing of polo-like kinase (Plk) 1 via siRNA causes inhibition of growth and induction of apoptosis in human esophageal cancer cells

30 October 2018

1 reference

12 December 2020

Ewing sarcoma family of tumors

1 reference

12 December 2020

NF-kappa B activation results in rapid inactivation of JNK in TNF alpha-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-kappa B

1 reference

12 December 2020

Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells

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12 December 2020

Identifiers

DOI

10.1186/1476-4598-9-218

1 reference

Dimensions Publication ID

28 July 2017

1 reference

https://scigraph.springernature.com/pub.10.1186/1476-4598-9-218

9 September 2019

1 reference

28 July 2017

1 reference