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Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche.
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Europe PubMed Central
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4034424
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24866116%20AND%20SRC:MED&resulttype=core&format=json
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19 March 2020
title
Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche
(English)
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stated in
Europe PubMed Central
PMC publication ID
4034424
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24866116%20AND%20SRC:MED&resulttype=core&format=json
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19 March 2020
author
Merlin Nithya Gnanapragasam
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3
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Europe PubMed Central
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4034424
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19 March 2020
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Li Xue
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1
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Europe PubMed Central
PMC publication ID
4034424
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24866116%20AND%20SRC:MED&resulttype=core&format=json
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19 March 2020
Mariann Galdass
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2
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Europe PubMed Central
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4034424
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24866116%20AND%20SRC:MED&resulttype=core&format=json
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19 March 2020
Deepa Manwani
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4
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19 March 2020
James J Bieker
series ordinal
5
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Europe PubMed Central
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4034424
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24866116%20AND%20SRC:MED&resulttype=core&format=json
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19 March 2020
language of work or name
English
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publication date
1 June 2014
1 reference
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Europe PubMed Central
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4034424
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19 March 2020
number of pages
10
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Development
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Europe PubMed Central
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19 March 2020
volume
141
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Europe PubMed Central
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4034424
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19 March 2020
issue
11
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Europe PubMed Central
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4034424
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19 March 2020
page(s)
2245-2254
1 reference
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Europe PubMed Central
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4034424
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19 March 2020
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A dominant mutation in the gene encoding the erythroid transcription factor KLF1 causes a congenital dyserythropoietic anemia
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A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells
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Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2.
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The erythroblastic island
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Adherence to macrophages in erythroblastic islands enhances erythroblast proliferation and increases erythrocyte production by a different mechanism than erythropoietin
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Sumoylation of EKLF promotes transcriptional repression and is involved in inhibition of megakaryopoiesis
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All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac.
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Novel role for EKLF in megakaryocyte lineage commitment
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Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice
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Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation
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21 June 2018
A global role for EKLF in definitive and primitive erythropoiesis
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Hematopoiesis in the yolk sac: more than meets the eye.
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21 June 2018
The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability
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Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
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Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA
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Activation and repression of interleukin-12 p40 transcription by erythroid Kruppel-like factor in macrophages
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
21 June 2018
HEME SYNTHESIS IN ERYTHROID CELLS.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
21 June 2018
Characterization of mouse clonogenic megakaryocyte progenitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
21 June 2018
The BMP/BMPR/Smad pathway directs expression of the erythroid-specific EKLF and GATA1 transcription factors during embryoid body differentiation in serum-free media.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
21 June 2018
Intercellular adhesion molecule-4 binds alpha(4)beta(1) and alpha(V)-family integrins through novel integrin-binding mechanisms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
21 June 2018
Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
21 June 2018
Spatial and temporal emergence of high proliferative potential hematopoietic precursors during murine embryogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
21 June 2018
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
21 June 2018
Molecular identification and functional characterization of a novel protein that mediates the attachment of erythroblasts to macrophages
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
21 June 2018
Chromatin structure and transcriptional control elements of the erythroid Krüppel-like factor (EKLF) gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
21 June 2018
Erythroid Krüppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
21 June 2018
Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
21 June 2018
A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
21 June 2018
Exploring the erythroblastic island.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
Molecular analysis of the rare in(Lu) blood type: toward decoding the phenotypic outcome of haploinsufficiency for the transcription factor KLF1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
Inhibition of erythropoiesis by Smad6 in human cord blood hematopoietic stem cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
Erythropoietin stimulates spleen BMP4-dependent stress erythropoiesis and partially corrects anemia in a mouse model of generalized inflammation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
Use of transgenic fluorescent reporter mouse lines to monitor hematopoietic and erythroid development during embryogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
Mutation in erythroid specific transcription factor KLF1 causes Hereditary Spherocytosis in the Nan hemolytic anemia mouse model
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
Activation of Eklf expression during hematopoiesis by Gata2 and Smad5 prior to erythroid commitment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
Macrophages function as a ferritin iron source for cultured human erythroid precursors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
Disruption of palladin leads to defects in definitive erythropoiesis by interfering with erythroblastic island formation in mouse fetal liver.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
A detailed study of time-dependent changes in human red blood cells: from reticulocyte maturation to erythrocyte senescence.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
Three pathways to mature macrophages in the early mouse yolk sac.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
Prospective isolation and global gene expression analysis of the erythrocyte colony-forming unit (CFU-E).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
Homotypic signalling regulates Gata1 activity in the erythroblastic island.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
Regulatory elements of the EKLF gene that direct erythroid cell-specific expression during mammalian development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
Hematopoietic commitment of ES cells in culture
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
Identification of critical amino-acid residues on the erythroid intercellular adhesion molecule-4 (ICAM-4) mediating adhesion to alpha V integrins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
Very late activation antigen 4-vascular cell adhesion molecule 1 interaction is involved in the formation of erythroblastic islands
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034424
retrieved
30 October 2018
c-Maf plays a crucial role for the definitive erythropoiesis that accompanies erythroblastic island formation in the fetal liver
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24866116
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Impaired splenic erythropoiesis in phlebotomized mice injected with CL2MDP-liposome: an experimental model for studying the role of stromal macrophages in erythropoiesis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24866116
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
[Erythroblastic island, functional unity of bone marrow]
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24866116
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1242/DEV.103960
1 reference
stated in
Europe PubMed Central
PMC publication ID
4034424
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24866116%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
PMC publication ID
4034424
1 reference
stated in
Europe PubMed Central
PMC publication ID
4034424
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24866116%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
PubMed publication ID
24866116
1 reference
stated in
Europe PubMed Central
PMC publication ID
4034424
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24866116%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 March 2020
ResearchGate publication ID
262681814
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