(Q33677437)

28 July 2017

title

A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway (English)

1 reference

28 July 2017

R J Carroll

1

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28 July 2017

R E Hammer

2

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28 July 2017

S J Chan

3

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28 July 2017

H H Swift

4

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28 July 2017

A H Rubenstein

5

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28 July 2017

D F Steiner

6

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28 July 2017

language of work or name

English

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publication date

1 December 1988

1 reference

Proceedings of the National Academy of Sciences of the United States of America

28 July 2017

published in

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28 July 2017

volume

85

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28 July 2017

issue

23

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28 July 2017

page(s)

8943-8947

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Familial hyperproinsulinemia. Two cohorts secreting indistinguishable type II intermediates of proinsulin conversion

28 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

Dynamic synthesis and release of insulin and proinsulin from perifused islets.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

Studies on the secretion of newly synthesized proinsulin and insulin from isolated rat islets of Langerhans

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

Posttranslational cleavage of proinsulin is blocked by a point mutation in familial hyperproinsulinemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

Pancreatic expression of human insulin gene in transgenic mice.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

A mutation in the B chain coding region is associated with impaired proinsulin conversion in a family with hyperproinsulinemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

Constitutive and regulated secretion of proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

A superactive insulin: [B10-aspartic acid]insulin(human).

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

Quantitative study of insulin secretion and clearance in normal and obese subjects

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

Characterization of the two nonallelic genes encoding mouse preproinsulin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

Proinsulin radioimmunoassay in the evaluation of insulinomas and familial hyperproinsulinemia.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

Receptor-mediated endocytosis: concepts emerging from the LDL receptor system

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

The relation of conformation and association of insulin to receptor binding; x-ray and circular-dichroism studies on bovine and hystricomorph insulins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

Preparation and characterization of plasma membrane-enriched fractions from rat pancreatic islets

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

Retention and degradation of 125I-insulin by perfused livers from diabetic rats

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

Familial hyperproinsulinemia due to a proposed defect in conversion of proinsulin to insulin.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

Studies on the molecular organization of rat insulin secretory granules.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282623

Regulation of human insulin gene expression in transgenic mice

30 October 2018

1 reference

12 December 2020

Monomeric insulins obtained by protein engineering and their medical implications

1 reference

12 December 2020

28 Methods for the assessment of peptide precursors. Studies on insulin biosynthesis

1 reference

12 December 2020

Recovery of DNA segments from agarose gels

1 reference

12 December 2020

The insulin gene is located on chromosome 11 in humans

1 reference

12 December 2020

Reversed-phase high-performance liquid chromatography of insulins from different species

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.85.23.8943

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28 July 2017

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28 July 2017

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