(Q33678321)

28 July 2017

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title

A risk-benefit assessment of metformin in type 2 diabetes mellitus (English)

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28 July 2017

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H C Howlett

1

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28 July 2017

C J Bailey

series ordinal

2

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28 July 2017

publication date

1 June 1999

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28 July 2017

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28 July 2017

volume

20

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28 July 2017

issue

6

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28 July 2017

page(s)

489-503

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Comparative three-month study of the efficacies of metformin and gliclazide in the treatment of NIDD.

28 July 2017

cites work

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Metabolic effects of metformin addition to chronic glibenclamide treatment in type 2 diabetes.

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Metformin improves peripheral vascular flow in nonhyperlipidemic patients with arterial disease.

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Lactic acidosis in patients with diabetes treated with metformin

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Comparative effects of glibenclamide and metformin on ambulatory blood pressure and cardiovascular reactivity in NIDDM

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12 December 2020

Oral antihyperglycaemics. Considerations in older patients with non-insulin-dependent diabetes mellitus

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12 December 2020

Metformin: a review of its pharmacological properties and therapeutic use

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Lactic acidosis rates in type 2 diabetes

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12 December 2020

Antihyperglycaemic efficacy, response prediction and dose-response relations of treatment with metformin and sulphonylurea, alone and in primary combination.

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12 December 2020

UKPDS 28: a randomized trial of efficacy of early addition of metformin in sulfonylurea-treated type 2 diabetes. U.K. Prospective Diabetes Study Group

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12 December 2020

The reduction of low density lipoprotein cholesterol by metformin is maintained with long-term therapy.

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12 December 2020

Mortality trends and causes of death in diabetic patients

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12 December 2020

Hemodialysis in the treatment of lactic acidosis in diabetics treated by metformin: a study of metformin elimination

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12 December 2020

Metabolic and drug distribution studies do not support direct inhibitory effects of metformin on intestinal glucose absorption

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12 December 2020

Sulfonylurea-metformin-combination versus sulfonylurea-insulin-combination in secondary failures of sulfonylurea monotherapy. Results of a prospective randomized study in 50 patients

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12 December 2020

Effect of Metformin on Glucose Disposal and Hyperinsulinaemia in a 14-Year-Old Boy with Acanthosis Nigricans

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12 December 2020

Disposition of metformin (N,N-dimethylbiguanide) in man.

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12 December 2020

A prospective study of the effect of 12 months treatment on serum lipids and apolipoproteins A-I and B in Type 2 (non-insulin-dependent) diabetes

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12 December 2020

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12 December 2020

The Distribution and Severity of Diabetic Foot Disease: a Community Study with Comparison to a Non-diabetic Group

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12 December 2020

Metformin and insulin: is there a role for combination therapy?

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12 December 2020

Metformin reduces insulin requirement in Type 1 (insulin-dependent) diabetes

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12 December 2020

Metformin kinetics in healthy subjects and in patients with diabetes mellitus

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12 December 2020

Oral hypoglycemic agents

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12 December 2020

Metformin and metoprolol CR treatment in non-obese men.

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12 December 2020

UK Prospective Diabetes Study 6. Complications in newly diagnosed type 2 diabetic patients and their association with different clinical and biochemical risk factors

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12 December 2020

Comparison of bedtime insulin regimens in patients with type 2 diabetes mellitus. A randomized, controlled trial

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12 December 2020

United Kingdom Prospective Diabetes Study 24: a 6-year, randomized, controlled trial comparing sulfonylurea, insulin, and metformin therapy in patients with newly diagnosed type 2 diabetes that could not be controlled with diet therapy. United Kingd

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12 December 2020

Hyperglycemia and microvascular and macrovascular disease in diabetes

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12 December 2020

Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells

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12 December 2020

The effect of metformin and insulin on sympathetic nerve activity, norepinephrine spillover and blood pressure in obese, insulin resistant, normoglycemic, hypertensive men.

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12 December 2020

Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy

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12 December 2020

Epidemiology of adverse drug reactions to phenformin and metformin

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12 December 2020

Is metformin safe enough for ageing type 2 diabetic patients?

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12 December 2020

Metformin administration in hyperlipidemic states

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12 December 2020

Metformin and intestinal glucose handling

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12 December 2020

Metformin increases glucose transporter protein and gene expression in human fibroblasts

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12 December 2020

The effects of metformin compared to the effects of phenformin on the lactate production and the metabolism of isolated parenchymal rat liver cell

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12 December 2020

Effect of metformin on glucose metabolism in the splanchnic bed

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12 December 2020

Health care expenditures for people with diabetes mellitus, 1992.

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12 December 2020

Results of a placebo-controlled study of the metabolic effects of the addition of metformin to sulfonylurea-treated patients. Evidence for a central role of adipose tissue

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12 December 2020

Sulphonylureas and hypoglycaemia

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12 December 2020

Biguanide-associated lactic acidosis. Case report and review of the literature

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12 December 2020

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

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12 December 2020

Efficacy of metformin in type II diabetes: results of a double-blind, placebo-controlled, dose-response trial.

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12 December 2020

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

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12 December 2020

Primary prevention of non‐insulin‐dependent diabetes mellitus

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12 December 2020

Effect of metformin on lipid metabolism in the rabbit aortic wall

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12 December 2020

Malabsorption of Vitamin B12 in Diabetic Patients Treated with Phenformin: A Comparison with Metformin

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12 December 2020

The clinical implications of impaired glucose tolerance

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12 December 2020

Demonstration of defective glucose uptake and storage in erythrocytes from non-insulin dependent diabetic patients and effects of metformin.

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12 December 2020

Metformin and free fatty acid metabolism

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12 December 2020

The effect of metformin on glycaemic control, intermediary metabolism and blood pressure in non-insulin-dependent diabetes mellitus.

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12 December 2020

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12 December 2020

Drug-induced hypoglycemia. A review of 1418 cases.

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12 December 2020

Metformin improves blood lipid pattern in nondiabetic patients with coronary heart disease.

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12 December 2020

Re-evaluation of a biguanide, metformin: mechanism of action and tolerability

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12 December 2020

Effect of metformin on carbohydrate and lipoprotein metabolism in NIDDM patients

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12 December 2020

Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus.

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12 December 2020

Meformin, plasma glucose and free fatty acids in type II diabetic out-patients: results of a clinical study

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12 December 2020

Sulphonylurea failure in type 2 diabetes: treatment with a basal insulin supplement.

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12 December 2020

The economics of pharmacotherapy for diabetes mellitus

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12 December 2020

The effects of metformin on glycemic control and serum lipids in insulin-treated NIDDM patients with suboptimal metabolic control.

1 reference

12 December 2020

Effects of metformin on insulin resistance, risk factors for cardiovascular disease, and plasminogen activator inhibitor in NIDDM subjects. A study of two ethnic groups.

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12 December 2020

Combination therapy with insulin and metformin

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12 December 2020

Effects of alpha-glucosidase inhibitor (acarbose) combined with sulfonylurea or sulfonylurea and metformin in treatment of non-insulin-dependent diabetes mellitus.

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12 December 2020

Insulin resistance implications for type II diabetes mellitus and coronary heart disease

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12 December 2020

Oral antidiabetic combination therapy with sulphonylureas and metformin.

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12 December 2020

Accumulation of metformin by tissues of the normal and diabetic mouse

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12 December 2020

Pharmacokinetics of metformin after intravenous and oral administration to man

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12 December 2020

Therapeutic comparison of metformin and sulfonylurea, alone and in various combinations. A double-blind controlled study.

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12 December 2020

Hyperinsulinemia as an independent risk factor for ischemic heart disease.

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12 December 2020

Incidence of severe sideeffects during therapy with sulfonylureas and biguanides.

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12 December 2020

Effect of metformin on bile salt circulation and intestinal motility in type 2 diabetes mellitus.

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12 December 2020

Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease

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12 December 2020

Comparison of tolbutamide and metformin in elderly diabetic patients

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12 December 2020

The impact of metformin therapy on hepatic glucose production and skeletal muscle glycogen synthase activity in overweight type II diabetic patients.

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12 December 2020

Energy Expenditure in Type 2 Diabetic Patients on Metformin and Sulphonylurea Therapy

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12 December 2020

Insulin-sensitising agents in polycystic-ovary syndrome.

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12 December 2020

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12 December 2020

Leucocytoclastic vasculitis and pneumonitis induced by metformin

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12 December 2020

Metformin for obese, insulin-treated diabetic patients: improvement in glycaemic control and reduction of metabolic risk factors.

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12 December 2020

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12 December 2020

Metformin therapy is associated with a decrease in plasma plasminogen activator inhibitor-1, lipoprotein(a), and immunoreactive insulin levels in patients with the polycystic ovary syndrome.

1 reference

12 December 2020

Double-blind evaluation of efficacy and tolerability of metformin in NIDDM.

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12 December 2020

Treatment with low dose metformin in patients with peripheral vascular disease

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12 December 2020

The status of metformin in Canada

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12 December 2020

Acute antihyperglycemic mechanisms of metformin in NIDDM. Evidence for suppression of lipid oxidation and hepatic glucose production

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12 December 2020

Metformin-associated lactic acidosis in Sweden 1977-1991

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12 December 2020

Metformin decreases the high plasminogen activator inhibition capacity, plasma insulin and triglyceride levels in non-diabetic obese subjects.

1 reference

12 December 2020

Clinical pharmacokinetics of metformin

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12 December 2020

Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group.

1 reference

12 December 2020

Glucose and lipid metabolism in non-insulin-dependent diabetes. Effect of metformin.

1 reference

12 December 2020

Metformin action on lipid metabolism in lesions of experimental aortic atherosclerosis of rabbits

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12 December 2020

Lactic acidotic coma with multiple medication including metformin in a patient with normal renal function

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12 December 2020

Metformin blocks downregulation of cell surface GLUT4 caused by chronic insulin treatment of rat adipocytes

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12 December 2020

A comparison of treatment with metformin and gliclazide in patients with non-insulin-dependent diabetes.

1 reference

12 December 2020

Reduction of metformin renal tubular secretion by cimetidine in man

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12 December 2020

Insulin and atheroma. 20-yr perspective

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12 December 2020

Comparative tolerability profiles of oral antidiabetic agents

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12 December 2020

Comparison of metformin and chlorpropamide in non-obese, maturity-onset diabetics uncontrolled by diet

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12 December 2020

Lawrence Lecture. Hypoglycaemia and diabetes

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12 December 2020

Comparison of chlorpropamide and metformin treatment on weight and blood-glucose response of uncontrolled obese diabetics

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12 December 2020

Effect of metformin on insulin-stimulated glucose turnover and insulin binding to receptors in type II diabetes

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12 December 2020

Different effects of insulin and oral antidiabetic agents on glucose and energy metabolism in type 2 (non-insulin-dependent) diabetes mellitus

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12 December 2020

Potentiating effect of metformin on insulin-induced glucose uptake and glycogen metabolism with Xenopus oocytes

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12 December 2020

Changes in insulin receptor tyrosine kinase activity associated with metformin treatment of type 2 diabetes

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12 December 2020

Metabolic and hemodynamic effects of metformin and glibenclamide in normotensive NIDDM patients.

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12 December 2020

Metformin-associated lactic acidosis: a rare or very rare clinical entity?

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12 December 2020

Effect of glycaemic control, metformin and gliclazide on platelet density and aggregability in recently diagnosed type 2 (non-insulin-dependent) diabetic patients.

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12 December 2020

Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus

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12 December 2020

The epidemiology of coronary heart disease in glucose-intolerant and diabetic subjects.

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12 December 2020

Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects.

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12 December 2020

The insulin-sparing effect of metformin in insulin-treated diabetic patients

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12 December 2020

The effect of metformin on adipose tissue metabolism and peripheral blood flow in subjects with NIDDM.

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12 December 2020

Metformin improves hemodynamic and rheological responses to L-arginine in NIDDM patients.

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12 December 2020

Metformin and the sulphonylureas: the comparative risk

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12 December 2020

Improvement of insulin sensitivity by metformin treatment does not lower blood pressure of nonobese insulin-resistant hypertensive patients with normal glucose tolerance

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12 December 2020

Comparison of combined therapies in treatment of secondary failure to glyburide

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12 December 2020

Metformin-induced lactic acidosis in the presence of acute renal failure

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12 December 2020

Mortality and survival in type 2 (non-insulin-dependent) diabetes mellitus

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12 December 2020

Diarrhea and Metformin in a Diabetic Clinic

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12 December 2020

Pathogenesis of NIDDM. A balanced overview

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12 December 2020

Worldwide experience of metformin as an effective glucose-lowering agent: a meta-analysis

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12 December 2020

Metformin increases insulin sensitivity and basal glucose clearance in Type 2 (non-insulin dependent) diabetes mellitus

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12 December 2020

Effect of metformin treatment on insulin action in diabetic rats: in vivo and in vitro correlations.

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12 December 2020

Management of non-insulin-dependent diabetes mellitus in Europe: a concensus view

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12 December 2020

Effect of metformin on postprandial lipemia in patients with fairly to poorly controlled NIDDM.

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12 December 2020

An overview of metformin in the treatment of type 2 diabetes mellitus

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12 December 2020

The antidiabetic drug metformin elevates receptor tyrosine kinase activity and inositol 1,4,5-trisphosphate mass in Xenopus oocytes

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12 December 2020

Lactic acidosis in biguanide-treated diabetics: a review of 330 cases

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12 December 2020

Metabolic effects of metformin in non-insulin-dependent diabetes mellitus

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12 December 2020

Banting lecture 1988. Role of insulin resistance in human disease

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12 December 2020

Role of metformin accumulation in metformin-associated lactic acidosis

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12 December 2020

Acarbose for the treatment of type II diabetes: the results of a Canadian multi-centre trial.

1 reference

12 December 2020

Metformin improves glucose, lipid metabolism, and reduces blood pressure in hypertensive, obese women.

1 reference

12 December 2020

The effect of metformin on the metabolic abnormalities associated with upper-body fat distribution. BIGPRO Study Group.

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12 December 2020

Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome

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12 December 2020

Biguanides and sulfonylureas as combination therapy in NIDDM.

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12 December 2020

Association of Metformin's Effect to Increase Insulin-Stimulated Glucose Transport With Potentiation of Insulin-Induced Translocation of Glucose Transporters From Intracellular Pool to Plasma Membrane in Rat Adipocytes

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12 December 2020

Lactic acidosis associated with Glucophage use in a man with normal renal and hepatic function

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12 December 2020

The effects of high- and medium-dose metformin therapy on cardiovascular risk factors in patients with type II diabetes.

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12 December 2020

Kidney function and age are both predictors of pharmacokinetics of metformin.

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12 December 2020

Metformin and lactic acidosis--a reminder

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12 December 2020

10.2165/00002018-199920060-00003

Identifiers

DOI

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Dimensions Publication ID

28 July 2017

1042971912

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