(Q33691348)

28 July 2017

title

Lovastatin inhibits VEGFR and AKT activation: synergistic cytotoxicity in combination with VEGFR inhibitors (English)

1 reference

28 July 2017

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Tong T Zhao

1

1 reference

28 July 2017

Diane Trinh

series ordinal

2

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28 July 2017

Christina L Addison

series ordinal

3

1 reference

28 July 2017

Jim Dimitroulakos

series ordinal

4

1 reference

28 July 2017

language of work or name

English

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publication date

3 September 2010

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28 July 2017

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28 July 2017

volume

5

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28 July 2017

issue

9

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28 July 2017

page(s)

e12563

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Creative Commons Attribution 4.0 International

28 July 2017

copyright license

start time

3 September 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: potential regulation by targeting rho proteins

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In vivo evidence of duality effects for lovastatin in a nude mouse cancer model.

21 June 2018

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Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin

21 June 2018

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Recent advances in the treatment of malignant pleural mesothelioma.

21 June 2018

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Targeting the AKT protein kinase for cancer chemoprevention

21 June 2018

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Update on the molecular biology of malignant mesothelioma

21 June 2018

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The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms

21 June 2018

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Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF).

21 June 2018

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Erlotinib in previously treated non-small-cell lung cancer

21 June 2018

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21 June 2018

Cancer without disease.

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AP-1: a double-edged sword in tumorigenesis

21 June 2018

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Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF.

21 June 2018

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Vascular endothelial growth factor receptor tyrosine kinase inhibitors: PTK787/ZK 222584.

21 June 2018

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The biology of VEGF and its receptors

21 June 2018

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The statins as anticancer agents

21 June 2018

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21 June 2018

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Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae

21 June 2018

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Epidermal growth factor receptor structure, regulation, mitogenic signalling and effects of activation

21 June 2018

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Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis

21 June 2018

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The EGF receptor family as targets for cancer therapy

21 June 2018

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Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications

21 June 2018

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Requirement of cortical actin organization for bombesin, endothelin, and EGF receptor internalization

21 June 2018

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Suppression of invasion and MMP-9 expression in NIH 3T3 and v-H-Ras 3T3 fibroblasts by lovastatin through inhibition of ras isoprenylation

21 June 2018

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Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer.

21 June 2018

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Inhibitors of prenyl transferases.

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933231

Mechanisms of angiogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933231

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933231

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933231

Pharmacology of competitive inhibitors of HMG-CoA reductase.

21 June 2018

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Malignant mesothelioma of the pleura: review of 123 patients

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933231

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933231

Synthesis of epidermal growth factor receptor in human A431 cells. Glycosylation-dependent acquisition of ligand binding activity occurs post-translationally in the endoplasmic reticulum.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933231

Regulation of the mevalonate pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933231

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933231

Vascular endothelial growth factor is an autocrine growth factor in human malignant mesothelioma

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012563

Epidermal growth factor receptor-targeted therapy potentiates lovastatin-induced apoptosis in head and neck squamous cell carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012563

Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012563

A Phase I trial of prolonged administration of lovastatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or of the cervix

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012563

Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012563

KRN633: A selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase that suppresses tumor angiogenesis and growth

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933231

Biotransformation of lovastatin. V. Species differences in in vivo metabolite profiles of mouse, rat, dog, and human.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933231

Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933231

Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin

30 October 2018

1 reference

12 December 2020

Angiogenic cytokines in mesothelioma: a study of VEGF, FGF-1 and -2, and TGF beta expression

1 reference

12 December 2020

A novel endocytic mechanism of epidermal growth factor receptor sequestration and internalization

1 reference

12 December 2020

VEGF and VEGFR-2 (KDR) internalization is required for endothelial recovery during wound healing

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0012563

Identifiers

DOI

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28 July 2017

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28 July 2017

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