(Q33698006)

28 July 2017

title

The Goldilocks model for TCR-too much attraction might not be best for vaccine design (English)

1 reference

28 July 2017

The Goldilocks Model for TCR—Too Much Attraction Might Not Be Best for Vaccine Design (English)

1 reference

10.1371/JOURNAL.PBIO.1000482

DOI

https://api.crossref.org/works/10.1371/JOURNAL.PBIO.1000482

17 July 2024

1 reference

modelling biological systems

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856901

17 July 2024

author name string

Jill E. Slansky

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856901

17 July 2024

Kimberly R. Jordan

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856901

17 July 2024

language of work or name

English

0 references

publication date

14 September 2010

1 reference

full work available at URL

28 July 2017

https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000482&type=printable

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856901

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20856901/pdf/?tool=EBI

17 July 2024

file format

Portable Document Format

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856901

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20856901/?tool=EBI

17 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856901

https://europepmc.org/articles/PMC2939021

17 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856901

https://europepmc.org/articles/PMC2939021?pdf=render

17 July 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856901

http://dx.plos.org/10.1371/journal.pbio.1000482

17 July 2024

1 reference

10.1371/JOURNAL.PBIO.1000482

DOI

https://api.crossref.org/works/10.1371/JOURNAL.PBIO.1000482

17 July 2024

1 reference

28 July 2017

volume

8

1 reference

28 July 2017

issue

9

1 reference

Creative Commons Attribution 4.0 International

28 July 2017

copyright license

start time

14 September 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939021

Peptide vaccines prevent tumor growth by activating T cells that respond to native tumor antigens

21 June 2018

1 reference

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Complete but curtailed T-cell response to very low-affinity antigen

21 June 2018

1 reference

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Helper T-cell responses and clinical activity of a melanoma vaccine with multiple peptides from MAGE and melanocytic differentiation antigens

21 June 2018

1 reference

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Fetal exposure to high-avidity TCR ligand enhances expansion of peripheral T regulatory cells

21 June 2018

1 reference

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Adoptive cell transfer: a clinical path to effective cancer immunotherapy

21 June 2018

1 reference

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High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.

21 June 2018

1 reference

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Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939021

Relating TCR-peptide-MHC affinity to immunogenicity for the design of tumor vaccines

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939021

Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939021

Antigen-specific T cells: analyses of the needles in the haystack

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939021

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939021

V(D)J Recombination and the Evolution of the Adaptive Immune System

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939021

TCRs with high affinity for foreign pMHC show self-reactivity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939021

Alteration at a single amino acid residue in the T cell receptor alpha chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 (Th1) to Th2.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939021

In vitro evolution of a T cell receptor with high affinity for peptide/MHC.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939021

Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939021

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939021

Kinetic proofreading in T-cell receptor signal transduction

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939021

Serial triggering of many T-cell receptors by a few peptide-MHC complexes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939021

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939021

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000482

Ligand recognition by alpha beta T cell receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000482

Directed evolution of human T-cell receptors with picomolar affinities by phage display.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000482

How the T Cell Repertoire Becomes Peptide and MHC Specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000482

Crystallization and X-ray diffraction studies on the histocompatibility antigens HLA-A2 and HLA-A28 from human cell membranes

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20856901

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20856901

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PBIO.1000482

1 reference

28 July 2017

1 reference

28 July 2017

1 reference