(Q33699333)

28 July 2017

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title

Merck Frosst Award Lecture 1998. Molecular dissection of the human multidrug resistance P-glycoprotein (English)

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28 July 2017

main subject

multiple drug resistance

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T W Loo

1

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28 July 2017

D M Clarke

series ordinal

2

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28 July 2017

language of work or name

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1 January 1999

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Biochemistry and Cell Biology

28 July 2017

published in

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28 July 2017

volume

77

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28 July 2017

issue

1

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28 July 2017

page(s)

11-23

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Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis

28 July 2017

cites work

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Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein

21 January 2018

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Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

21 January 2018

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The tissue dependent expression of hamster P-glycoprotein genes

21 January 2018

1 reference

Chromosomal location of human P-glycoprotein gene sequences.

21 January 2018

1 reference

Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative

21 January 2018

1 reference

Hypothesis about the function of membrane-buried proline residues in transport proteins

21 January 2018

1 reference

Diagnosis and reversal of multidrug resistance in paediatric cancers

21 January 2018

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Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

21 January 2018

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Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

21 January 2018

1 reference

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

21 January 2018

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Pharmacological considerations in the modulation of multidrug resistance

21 January 2018

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Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.

21 January 2018

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Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

21 January 2018

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MDR1 gene expression in solid tumours

21 January 2018

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P-glycoprotein and multidrug resistance

21 January 2018

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Isolation and expression of a complementary DNA that confers multidrug resistance

21 January 2018

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Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins

21 January 2018

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The ABC of channel regulation

21 January 2018

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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

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Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

21 January 2018

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The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

21 January 2018

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HIV-1 protease inhibitors and the MDR1 multidrug transporter

21 January 2018

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HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

21 January 2018

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Clinical multidrug resistance in cancer: a multifactorial problem

21 January 2018

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The p53 tumour suppressor gene

21 January 2018

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Proximity of the nucleotide binding domains of the P-glycoprotein multidrug transporter to the membrane surface: a resonance energy transfer study.

21 January 2018

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Membrane topology of a cysteine-less mutant of human P-glycoprotein

21 January 2018

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On the role of DmpK, an auxiliary protein associated with multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.

21 January 2018

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Failure of P-glycoprotein (MDR1) expressed in Xenopus oocytes to produce swelling-activated chloride channel activity.

21 January 2018

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Identification of members of the P-glycoprotein multigene family

21 January 2018

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Detection of oligomeric and monomeric forms of P-glycoprotein in multidrug resistant cells

21 January 2018

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Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells

21 January 2018

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Genetic and biochemical characterization of multidrug resistance

21 January 2018

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The role of the MDR protein in altered drug translocation across tumor cell membranes

21 January 2018

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Altered drug translocation mediated by the MDR protein: direct, indirect, or both?

21 January 2018

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Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.

21 January 2018

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Phosphatidylcholine translocase: a physiological role for the mdr2 gene

21 January 2018

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Search for specific inhibitors of multidrug resistance in cancer

21 January 2018

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The physiological function of drug-transporting P-glycoproteins

21 January 2018

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

21 January 2018

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P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans

21 January 2018

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The P-glycoprotein efflux pump: how does it transport drugs?

21 January 2018

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Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

21 January 2018

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Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators.

21 January 2018

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Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

21 January 2018

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p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents

21 January 2018

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Volume-sensitive chloride channel activity does not depend on endogenous P-glycoprotein

21 January 2018

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Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine

21 January 2018

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Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

21 January 2018

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Topological folding and proteolysis profile of P-glycoprotein in membranes of multidrug-resistant cells: implications for the drug-transport mechanism.

21 January 2018

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Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

21 January 2018

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Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/O99-014

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28 July 2017

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