(Q33702269)

28 July 2017

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title

Spinal systems and pain processing: development of novel analgesic drugs with mechanistically defined models (English)

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28 July 2017

Yaksh TL

1

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28 July 2017

1 August 1999

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Trends in Pharmacological Sciences

28 July 2017

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28 July 2017

20

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28 July 2017

329-337

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28 July 2017

8

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AMPA/Kainate Receptor Antagonists as Novel Analgesic Agents

28 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

A novel model of primary and secondary hyperalgesia after mild thermal injury in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

The induction of pain: an integrative review.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Myelinated afferents sprout into lamina II of L3-5 dorsal horn following chronic constriction nerve injury in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Peripheral nerve injury triggers central sprouting of myelinated afferents

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: effects of a chronic constriction injury, transection, and strychnine

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Loss of GABA-immunoreactivity in the spinal dorsal horn of rats with peripheral nerve injury and promotion of recovery by adrenal medullary grafts

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Schwann cells produce tumor necrosis factor alpha: expression in injured and non-injured nerves

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Tumour necrosis factor-alpha induces ectopic activity in nociceptive primary afferent fibres

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https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Characterization of a neuropathic pain model: sciatic cryoneurolysis in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Allodynia-like effects in rat after ischaemic spinal cord injury photochemically induced by laser irradiation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Study of the sensitivity of the diabetes-induced pain model in rats to a range of analgesics.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Vincristine hyperalgesia in the rat: a model of painful vincristine neuropathy in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

An animal model of pain produced by systemic administration of an immunotherapeutic anti-ganglioside antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Multiple mechanisms for the effects of capsaicin, bradykinin and nicotine on CGRP release from tracheal afferent nerves: role of prostaglandins, sympathetic nerves and mast cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Action of intrathecal capsaicin and its structural analogues on the content and release of spinal substance P: Selectivity of action and relationship to analgesia

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Epibatidine binding sites and activity in the spinal cord

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Effects of intrathecal NMDA and non-NMDA antagonists on acute thermal nociception and their interaction with morphine

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP-96,345: Antinociception in the absence of motor dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Glutamate receptors in the mammalian central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Localization of glutamate receptors in dorsal horn of rat spinal cord.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Intrathecal administration of the mGluR compound, (S)-4CPG, attenuates hyperalgesia and allodynia associated with sciatic nerve constriction injury in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Antinociceptive effect of intrathecally administered P2-purinoceptor antagonists in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Calcium signaling in neurons: molecular mechanisms and cellular consequences

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Localization of cyclooxygenase-2 and prostaglandin E2 receptor EP3 in the rat lumbar spinal cord

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Characterization of time course of spinal amino acids, citrulline and PGE2 release after carrageenan/kaolin-induced knee joint inflammation: a chronic microdialysis study

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Prostacyclin enhances the evoked-release of substance P and calcitonin gene-related peptide from rat sensory neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Intracellular calcium mobilization and neurite outgrowth in mammalian neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Protein kinase C isozyme expression in sciatic nerves and spinal cords of experimentally diabetic rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Cyclic AMP-dependent protein kinase and protein kinase C phosphorylate N-methyl-D-aspartate receptors at different sites.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Enhancement of the N-methyl-D-aspartate response in spinal dorsal horn neurons by cAMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Noxious thermal and chemical stimulation induce increases in 3H-phorbol 12,13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase C

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Neuroanatomical distribution of receptors for a novel voltage-sensitive calcium-channel antagonist, SNX-230 (omega-conopeptide MVIIC)

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Omega-conotoxin sensitivity and presynaptic inhibition of glutamatergic sensory neurotransmission in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Voltage-sensitive calcium channels in spinal nociceptive processing: blockade of N- and P-type channels inhibits formalin-induced nociception.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Pharmacological evidence for different alpha 2-adrenergic receptor sites mediating analgesia and sedation in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Colocalization of GABA, glycine, and their receptors at synapses in the rat spinal cord

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Effect of subarachnoid gabapentin on tactile-evoked allodynia in a surgically induced neuropathic pain model in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Mechanisms of paresthesiae, dysesthesiae, and hyperesthesiae: role of Na+ channel heterogeneity

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

The state of the art in antisense research

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Spinal neurokinin NK1 receptor down-regulation and antinociception: effects of spinal NK1 receptor antisense oligonucleotides and NK1 receptor occupancy.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Antisense ablation of type I metabotropic glutamate receptor mGluR1 inhibits spinal nociceptive transmission

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Long-term alleviation of allodynia-like behaviors by intrathecal implantation of bovine chromaffin cells in rats with spinal cord injury

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Intrathecal implants of bovine chromaffin cells alleviate mechanical allodynia in a rat model of neuropathic pain

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Implantation of AtT-20 or genetically modified AtT-20/hENK cells in mouse spinal cord induced antinociception and opioid tolerance.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Intrathecal delta-receptor ligand produces analgesia in man

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

The analgesic efficacy of intrathecal D-Ala2-D-Leu5-enkephalin in cancer patients with chronic pain

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

alpha(2)-adrenergic agonists for regional anesthesia. A clinical review of clonidine (1984-1995).

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Phase I safety assessment of intrathecal neostigmine methylsulfate in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

A multi-center study of intrathecal neostigmine for analgesia following vaginal hysterectomy

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

An A1-Selective Adenosine Agonist Abolishes Allodynia Elicited by Vibration and Touch After Intrathecal Injection

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

Use of intrathecal SNX-111, a novel, N-type, voltage-sensitive, calcium channel blocker, in the management of intractable brachial plexus avulsion pain

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

The NMDA antagonist 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) has antinociceptive effect after intrathecal injection in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901370-X

7 January 2021

10.1016/S0165-6147(99)01370-X

Identifiers

DOI

1 reference

28 July 2017

1 reference

PubMed ID

10431212