(Q33718420)

24755219

28 July 2017

title

Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells (English)

1 reference

28 July 2017

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755219%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Eduardo Munoz

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755219%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

author name string

Nicholas Don-Doncow

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755219%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Zilma Escobar

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755219%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Martin Johansson

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755219%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Victor Garcia

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755219%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Olov Sterner

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755219%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Anders Bjartell

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755219%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Rebecka Hellsten

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755219%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

language of work or name

English

0 references

publication date

22 April 2014

1 reference

24755219

Journal of Biological Chemistry

28 July 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755219%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

289

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755219%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

issue

23

1 reference

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31 May 2020

page(s)

15969-15978

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755219%20AND%20SRC:MED&resulttype=core&format=json

The fungal metabolite galiellalactone interferes with the nuclear import of NF-κB and inhibits HIV-1 replication

31 May 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

How should we define STAT3 as an oncogene and as a potential target for therapy?

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Castration-resistant prostate cancer: from new pathophysiology to new treatment

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Critical analysis of the potential for targeting STAT3 in human malignancy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

JAK-STAT blockade inhibits tumor initiation and clonogenic recovery of prostate cancer stem-like cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Molecular pathways: Jak/STAT pathway: mutations, inhibitors, and resistance

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Inhibition of TGF-β signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Acyloxy nitroso compounds inhibit LIF signaling in endothelial cells and cardiac myocytes: evidence that STAT3 signaling is redox-sensitive

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Potential use of STAT3 inhibitors in targeted prostate cancer therapy: future prospects

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Somatic STAT3 mutations in large granular lymphocytic leukemia

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Targeting the interleukin-6/Jak/stat pathway in human malignancies

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Galiellalactone inhibits stem cell-like ALDH-positive prostate cancer cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Stat3 promotes metastatic progression of prostate cancer.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Expression levels of the JAK/STAT pathway in the transition from hormone-sensitive to hormone-refractory prostate cancer.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Structure, function, and regulation of STAT proteins

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

STAT proteins as novel targets for cancer drug discovery

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

STAT proteins: From normal control of cellular events to tumorigenesis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Three-dimensional structure of the Stat3beta homodimer bound to DNA

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

The STAT3 oncogene as a predictive marker of drug resistance.

14 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.564252

Prostate cancer, Version 3.2012: featured updates to the NCCN guidelines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.564252

Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.564252

Modulation of Gene Expression and Tumor Cell Growth by Redox Modification of STAT3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.564252

Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4047371

Synthesis of (+)-galiellalactone. Absolute configuration of galiellalactone

30 October 2018

1 reference

12 December 2020

Clinical and pathologic significance of activation of signal transducer and activator of transcription 3 in prostate cancer

1 reference

12 December 2020

Inhibition of interleukin-6 signaling by galiellalactone

1 reference

12 December 2020

Targeting STAT3 in cancer: how successful are we?

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M114.564252

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755219%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755219%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

24755219

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755219%20AND%20SRC:MED&resulttype=core&format=json