(Q33720373)

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Insulin activation of the phosphatidylinositol 3-kinase/protein kinase B (Akt) pathway reduces lipopolysaccharide-induced inflammation in mice

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18445780%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Insulin activation of the phosphatidylinositol 3-kinase/protein kinase B (Akt) pathway reduces lipopolysaccharide-induced inflammation in mice (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18445780%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

lipopolysaccharide

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1 reference

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Gernot Schabbauer

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18445780%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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Linda B Kidd

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18445780%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

James P Luyendyk

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18445780%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Todd D Holscher

4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18445780%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Rachel E Tilley

5

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Europe PubMed Central

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6 January 2020

Michael Tencati

6

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Europe PubMed Central

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6 January 2020

Nigel Mackman

7

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Europe PubMed Central

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6 January 2020

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29 April 2008

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6 January 2020

Journal of Pharmacology and Experimental Therapeutics

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18445780%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

326

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18445780%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18445780%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

348-353

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18445780%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Intensive insulin therapy and pentastarch resuscitation in severe sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Insulin attenuates apoptosis and exerts anti-inflammatory effects in endotoxemic human macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Management of sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Critical nodes in signalling pathways: insights into insulin action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Intensive insulin therapy in the medical ICU.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Insulin signaling and the regulation of glucose transport.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Intensive insulin therapy protects the endothelium of critically ill patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Negative regulation of toll-like receptor-mediated immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

How does blood glucose control with insulin save lives in intensive care?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Insulin attenuates the systemic inflammatory response in endotoxemic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Stress-hyperglycemia, insulin and immunomodulation in sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Mechanisms of bacterial lipopolysaccharide-induced endothelial apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Cellular apoptosis and organ injury in sepsis: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Intensive insulin therapy in critically ill patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Insulin signaling leading to proliferation, survival, and membrane ruffling in C2C12 myoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

High glucose attenuates insulin-induced mitogen-activated protein kinase phosphatase-1 (MKP-1) expression in vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

The Primary Role of Lymphoreticnlar Cells in the Mediation of Host Responses to Bacterial Endotoxim

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Comparative and interactive in vivo effects of tumor necrosis factor alpha and endotoxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

Insulin-Stimulated Glucose Transport in Circulating Mononuclear Cells From Nondiabetic and IDDM Subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

21 June 2018

The in vivo contribution of hematopoietic cells to systemic TNF and IL-6 production during endotoxemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

30 October 2018

Inflammatory response during hyperglycemia and hyperinsulinemia in a porcine endotoxemic model: the contribution of essential organs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

30 October 2018

Insulin prevents liver damage and preserves liver function in lipopolysaccharide-induced endotoxemic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

30 October 2018

PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

30 October 2018

Acute hyperinsulinemia restrains endotoxin-induced systemic inflammatory response: an experimental study in a porcine model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

30 October 2018

Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment o

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

30 October 2018

Modulation of the phosphoinositide 3-kinase pathway alters innate resistance to polymicrobial sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

30 October 2018

Regulation of glucose transport and expression of GLUT3 transporters in human circulating mononuclear cells: studies in cells from insulin-dependent diabetic and nondiabetic individuals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836781

30 October 2018

Insulin-mediated stimulation of protein kinase Akt: A potent survival signaling cascade for endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18445780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/18445780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonists of phosphatidylinositol 3-kinase block activation of several novel protein kinases in neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/18445780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin reduces the multiple organ injury and dysfunction caused by coadministration of lipopolysaccharide and peptidoglycan independently of blood glucose: Role of glycogen synthase kinase-3β inhibition*

1 reference

https://pubmed.ncbi.nlm.nih.gov/18445780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperglycemia in children with meningococcal sepsis and septic shock: the relation between plasma levels of insulin and inflammatory mediators

1 reference

https://pubmed.ncbi.nlm.nih.gov/18445780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase II randomised controlled trial of intensive insulin therapy in general intensive care patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/18445780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in tissue glucose uptake during the hyperglycemic and hypoglycemic phases of sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18445780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-mediated cell proliferation and survival involve inhibition of c-Jun N-terminal kinases through a phosphatidylinositol 3-kinase- and mitogen-activated protein kinase phosphatase-1-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18445780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/JPET.108.138891

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18445780%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18445780%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18445780%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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