(Q33723852)

28 July 2017

title

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: what have we learned? (English)

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28 July 2017

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Rong Deng

1

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28 July 2017

Suhasini Iyer

2

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28 July 2017

Frank-Peter Theil

3

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28 July 2017

Deborah L Mortensen

4

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28 July 2017

Paul J Fielder

5

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28 July 2017

Saileta Prabhu

6

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28 July 2017

publication date

1 January 2011

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28 July 2017

published in

Monoclonal Antibodies

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28 July 2017

volume

3

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28 July 2017

issue

1

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28 July 2017

page(s)

61-66

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Population Pharmacokinetics of Therapeutic Monoclonal Antibodies

28 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038012

Interspecies scaling of therapeutic monoclonal antibodies: initial look

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038012

To scale or not to scale: the principles of dose extrapolation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038012

Pharmacokinetic allometric scaling of antibodies: application to the first-in-human dose estimation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038012

Role of fixed coefficients and exponents in the prediction of human drug clearance: how accurate are the predictions from one or two species?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038012

Preclinical pharmacokinetics, pharmacodynamics, and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038012

The origin of allometric scaling laws in biology from genomes to ecosystems: towards a quantitative unifying theory of biological structure and organization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038012

Interspecies scaling of protein drugs: prediction of clearance from animals to humans

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038012

Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038012

Interspecies scaling: predicting clearance of drugs in humans. Three different approaches

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038012

Interspecies pharmacokinetic scaling and the evolutionary-comparative paradigm

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038012

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038012

Prediction of human clearance of therapeutic proteins: simple allometric scaling method revisited.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038012

Accuracy of allometrically predicted pharmacokinetic parameters in humans: role of species selection.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038012

Interspecies scaling of the monoclonal anti-EGF receptor ior EGF/r3 antibody disposition using allometric paradigm: is it really suitable?

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038012

Pharmacokinetic scaling of bisphenol A by species-invariant time methods.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038012

Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038012

Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer

30 October 2018

1 reference

12 December 2020

A global examination of allometric scaling for predicting human drug clearance and the prediction of large vertical allometry

1 reference

12 December 2020

Pharmacokinetics and safety of a fully human hepatocyte growth factor antibody, AMG 102, in cynomolgus monkeys

1 reference

12 December 2020

Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of humanized monoclonal anti-IL-13 antibodies with different IL-13 neutralization mechanisms

1 reference

12 December 2020

Monoclonal antibody pharmacokinetics and pharmacodynamics

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12 December 2020

Physiological parameters in laboratory animals and humans

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12 December 2020

Identifiers

DOI

10.4161/MABS.3.1.13799

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28 July 2017

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28 July 2017

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