(Q33739113)

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Hypoxia and reoxygenation induce endothelial nitric oxide synthase uncoupling in endothelial cells through tetrahydrobiopterin depletion and S-glutathionylation

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Europe PubMed Central

PubMed publication ID

29 July 2017

Hypoxia and reoxygenation induce endothelial nitric oxide synthase uncoupling in endothelial cells through tetrahydrobiopterin depletion and S-glutathionylation (English)

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Europe PubMed Central

PubMed publication ID

29 July 2017

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1 reference

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Francesco De Pascali

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24758136%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

2

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24758136%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

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Kindra Samons

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24758136%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Chun-An Chen

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24758136%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Jay L Zweier

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24758136%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

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publication date

29 May 2014

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Europe PubMed Central

PubMed publication ID

29 July 2017

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24758136%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

53

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24758136%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

22

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24758136%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

3679-3688

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24758136%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4053070/fullTextXML

based on heuristic

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Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Tetrathiatriarylmethyl radical with a single aromatic hydrogen as a highly sensitive and specific superoxide probe

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

HPLC analysis of tetrahydrobiopterin and its pteridine derivatives using sequential electrochemical and fluorimetric detection: application to tetrahydrobiopterin autoxidation and chemical oxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Superoxide induces endothelial nitric-oxide synthase protein thiyl radical formation, a novel mechanism regulating eNOS function and coupling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Febuxostat inhibition of endothelial-bound XO: implications for targeting vascular ROS production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Mitochondrial redox metabolism: aging, longevity and dietary effects

1 reference

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21 June 2018

Nitric oxide production from nitrite occurs primarily in tissues not in the blood: critical role of xanthine oxidase and aldehyde oxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Characterization of superoxide production from aldehyde oxidase: an important source of oxidants in biological tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase: identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Enzymes of the L-arginine to nitric oxide pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Cardiovascular and renal control in NOS-deficient mouse models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Nitric oxide synthases: structure, function and inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Hypoxia-induced upregulation of eNOS gene expression is redox-sensitive: a comparison between hypoxia and inhibitors of cell metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Mechanisms underlying endothelial dysfunction in diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Status of myocardial antioxidants in ischemia-reperfusion injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

NAD(P)H oxidase: role in cardiovascular biology and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Molecular control of nitric oxide synthases in the cardiovascular system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Measurement and characterization of free radical generation in reoxygenated human endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

An NADPH oxidase superoxide-generating system in the rabbit aorta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Nitric oxide synthases: properties and catalytic mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Nitric oxide synthase: Aspects concerning structure and catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Ischemia-induced vascular changes: role of xanthine oxidase and hydroxyl radicals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Detection of superoxide generated by endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Oxygen-derived free radicals in postischemic tissue injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

21 June 2018

Phosphorylation of endothelial nitric-oxide synthase regulates superoxide generation from the enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

30 October 2018

Regulation of eNOS-derived superoxide by endogenous methylarginines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

30 October 2018

Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

30 October 2018

Prognostic value of coronary vascular endothelial dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

30 October 2018

Modulation of inducible nitric oxide synthase by hypoxia in pulmonary artery endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

30 October 2018

Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053070

30 October 2018

Formation of a Pterin Radical in the Reaction of the Heme Domain of Inducible Nitric Oxide Synthase with Oxygen†

1 reference

https://pubmed.ncbi.nlm.nih.gov/24758136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24758136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights on myocardial pyridine nucleotides and thiol redox state in ischemia and reperfusion damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/24758136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electron paramagnetic resonance spectroscopy with N-methyl-D-glucamine dithiocarbamate iron complexes distinguishes nitric oxide and nitroxyl anion in a redox-dependent manner: applications in identifying nitrogen monoxide products from nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/24758136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of reduced forms of biopterin in biological tissues and fluids

1 reference

https://pubmed.ncbi.nlm.nih.gov/24758136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/24758136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of the role of xanthine oxidase in myocardial reperfusion injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/24758136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of oxygen-derived free radicals in myocardial edema and ischemia in coronary microvascular embolization

1 reference

https://pubmed.ncbi.nlm.nih.gov/24758136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate Control of Free Radical Generation from Xanthine Oxidase in the Postischemic Heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/24758136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine deaminase inhibition prevents free radical-mediated injury in the postischemic heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/24758136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24758136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelial dysfunction coincides with an enhanced nitric oxide synthase expression and superoxide anion production

1 reference

https://pubmed.ncbi.nlm.nih.gov/24758136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels

1 reference

https://pubmed.ncbi.nlm.nih.gov/24758136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A short burst of oxygen radicals at reflow induces sustained release of oxidized glutathione from postischemic hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/24758136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelial dysfunction in chronic myocardial infarction despite increased vascular endothelial nitric oxide synthase and soluble guanylate cyclase expression: role of enhanced vascular superoxide production

1 reference

https://pubmed.ncbi.nlm.nih.gov/24758136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitrative inactivation of thioredoxin-1 and its role in postischemic myocardial apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24758136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes: evidence for their oxidative decarboxylation and molecular origin of their specific ability to react with O2*-

1 reference

https://pubmed.ncbi.nlm.nih.gov/24758136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox proteomics of thiol proteins in mouse heart during ischemia/reperfusion using ICAT reagents and mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/24758136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI500076R

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24758136%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24758136%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24758136%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

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