(Q33742761)

29 July 2017

title

Desensitization of functional µ-opioid receptors increases agonist off-rate (English)

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29 July 2017

0 references

1 reference

John T Williams

1

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29 July 2017

publication date

18 April 2014

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29 July 2017

published in

Molecular Pharmacology

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29 July 2017

volume

86

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29 July 2017

issue

1

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29 July 2017

page(s)

52-61

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Caged naloxone reveals opioid signaling deactivation kinetics

29 July 2017

cites work

1 reference

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Increased agonist affinity at the μ-opioid receptor induced by prolonged agonist exposure.

21 June 2018

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Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.

21 June 2018

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Differentiation of opioid drug effects by hierarchical multi-site phosphorylation

21 June 2018

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GIRK channel modulation by assembly with allosterically regulated RGS proteins

21 June 2018

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μ-Opioid receptor desensitization: homologous or heterologous?

21 June 2018

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Morphine desensitization and cellular tolerance are distinguished in rat locus ceruleus neurons

21 June 2018

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Photoactivatable neuropeptides for spatiotemporally precise delivery of opioids in neural tissue

21 June 2018

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Inactive-state preassembly of G(q)-coupled receptors and G(q) heterotrimers

21 June 2018

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Recovery from mu-opioid receptor desensitization after chronic treatment with morphine and methadone

21 June 2018

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Theme and variations on kinetics of GPCR activation/deactivation

21 June 2018

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Buprenorphine is a weak partial agonist that inhibits opioid receptor desensitization.

21 June 2018

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Abundance and stability of complexes containing inactive G protein-coupled receptors and G proteins

21 June 2018

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Kinetics of G-protein-coupled receptor signals in intact cells

21 June 2018

1 reference

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Signaling through a G Protein-coupled receptor and its corresponding G protein follows a stoichiometrically limited model

21 June 2018

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Rapid activation of inwardly rectifying potassium channels by immobile G-protein-coupled receptors.

21 June 2018

1 reference

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GIRK channel activation involves a local rearrangement of a preformed G protein channel complex

21 June 2018

1 reference

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Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells

21 June 2018

1 reference

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Gating properties of GIRK channels activated by Galpha(o)- and Galpha(i)-coupled muscarinic m2 receptors in Xenopus oocytes: the role of receptor precoupling in RGS modulation.

21 June 2018

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Characterization of acute homologous desensitization of mu-opioid receptor-induced currents in locus coeruleus neurones.

21 June 2018

1 reference

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Opiate-receptor interactions on single locus coeruleus neurones.

21 June 2018

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Kinetic evidence for differential agonist and antagonist binding to bovine hippocampal synaptic membrane opioid receptors

21 June 2018

1 reference

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Multiple agonist-affinity states of opioid receptors: regulation of binding by guanyl nucleotides in guinea pig cortical, NG108-15, and 7315c cell membranes

21 June 2018

1 reference

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Identification of two C-terminal amino acids, Ser(355) and Thr(357), required for short-term homologous desensitization of mu-opioid receptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054003

Efficacy and kinetics of opioid action on acutely dissociated neurons.

30 October 2018

1 reference

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Opioid desensitization: interactions with G-protein-coupled receptors in the locus coeruleus

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054003

30 October 2018

Identifiers

DOI

10.1124/MOL.114.092098

1 reference

29 July 2017

1 reference

29 July 2017

1 reference