(Q33744236)

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Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Soluble epoxide hydrolase

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pharmacokinetics

1 reference

based on heuristic

inferred from title

author name string

Shao-Xu Huang

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Hui-Yuan Li

2

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Jun-Yan Liu

3

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Christophe Morisseau

4

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Bruce D Hammock

5

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Europe PubMed Central

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29 July 2017

Ya-Qiu Long

6

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Europe PubMed Central

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29 July 2017

language of work or name

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publication date

11 November 2010

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Europe PubMed Central

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29 July 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

PubMed publication ID

29 July 2017

53

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Europe PubMed Central

PubMed publication ID

29 July 2017

23

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

8376-8386

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Rapid synthesis of an array of trisubstituted urea-based soluble epoxide hydrolase inhibitors facilitated by a novel solid-phase method

1 reference

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21 June 2018

Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs

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21 June 2018

Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase

1 reference

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Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases

1 reference

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Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase

1 reference

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21 June 2018

Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement

1 reference

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Soluble epoxide hydrolase, a target with multiple opportunities for cardiovascular drug discovery

1 reference

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Discovery of potent non-urea inhibitors of soluble epoxide hydrolase

1 reference

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Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation

1 reference

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Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein e-knockout mouse model

1 reference

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21 June 2018

1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties

1 reference

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21 June 2018

Orally bioavailable potent soluble epoxide hydrolase inhibitors

1 reference

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Beyond vasodilatation: non-vasomotor roles of epoxyeicosatrienoic acids in the cardiovascular system

1 reference

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Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase

1 reference

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21 June 2018

Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase

1 reference

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21 June 2018

The 5-substituted piperazine as a novel secondary pharmacophore greatly improving the physical properties of urea-based inhibitors of soluble epoxide hydrolase

1 reference

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21 June 2018

High-throughput pharmacokinetic method: cassette dosing in mice associated with minuscule serial bleedings and LC/MS/MS analysis

1 reference

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TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels.

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An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension

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A review of melanocortin receptor small molecule ligands

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Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies

1 reference

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Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility

1 reference

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21 June 2018

Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles

1 reference

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Solid-phase strategies for the design and synthesis of heterocyclic molecules of medicinal interest.

1 reference

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Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function

1 reference

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Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids

1 reference

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Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension

1 reference

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Epoxygenase pathways of arachidonic acid metabolism

1 reference

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Epoxide hydrolases: biochemistry and molecular biology

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Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase

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Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase

1 reference

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cDNA cloning and expression of a soluble epoxide hydrolase from human liver

1 reference

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Distinct rat hepatic microsomal epoxide hydrolases catalyze the hydration of cholesterol 5,6 alpha-oxide and certain xenobiotic alkene and arene oxides

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Affinity purification of cytosolic epoxide hydrolase using derivatized epoxy-activated Sepharose gels

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Cytosolic epoxide hydrolase

1 reference

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Purification of hepoxilin epoxide hydrolase from rat liver

1 reference

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Exploration of secondary and tertiary pharmacophores in unsymmetrical N,N'-diaryl urea inhibitors of soluble epoxide hydrolase

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Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors

1 reference

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Unsymmetrical non-adamantyl N,N'-diaryl urea and amide inhibitors of soluble expoxide hydrolase.

1 reference

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Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage.

1 reference

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Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility

1 reference

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Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels

1 reference

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Structural refinement of inhibitors of urea-based soluble epoxide hydrolases

1 reference

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Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells

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Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids

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30 October 2018

Identifiers

10.1021/JM101087U

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Europe PubMed Central

PubMed publication ID

29 July 2017

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24 November 2022

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29 July 2017

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29 July 2017

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