(Q33759715)

29 July 2017

title

Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells (English)

1 reference

29 July 2017

1 reference

Zhenfeng Zhang

1

1 reference

29 July 2017

Susumu Kobayashi

2

1 reference

29 July 2017

Alain C Borczuk

3

1 reference

29 July 2017

Rom S Leidner

4

1 reference

29 July 2017

Thomas Laframboise

5

1 reference

29 July 2017

Alan D Levine

6

1 reference

29 July 2017

Balazs Halmos

7

1 reference

29 July 2017

language of work or name

English

0 references

publication date

22 January 2010

1 reference

29 July 2017

number of pages

10

1 reference

based on heuristic

inferred from page(s)

published in

Carcinogenesis

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29 July 2017

volume

31

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29 July 2017

issue

4

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29 July 2017

page(s)

577-586

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Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis

29 July 2017

cites work

1 reference

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Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation

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21 June 2018

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DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility

21 June 2018

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15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer.

21 June 2018

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Dual-specificity MAP kinase phosphatases (MKPs) and cancer

21 June 2018

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Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter

21 June 2018

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21 June 2018

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Post-translational regulation of the ERK phosphatase DUSP6/MKP3 by the mTOR pathway.

21 June 2018

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Gene expression analysis of BCR/ABL1-dependent transcriptional response reveals enrichment for genes involved in negative feedback regulation

21 June 2018

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Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies

21 June 2018

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MAP kinase phosphatase activity sets the threshold for thymocyte positive selection

21 June 2018

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MAP kinase signalling pathways in cancer

21 June 2018

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Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses.

21 June 2018

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Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development

21 June 2018

1 reference

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Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signaling

21 June 2018

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Differential gene expression analysis reveals generation of an autocrine loop by a mutant epidermal growth factor receptor in glioma cells.

21 June 2018

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An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor.

21 June 2018

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Erlotinib in previously treated non-small-cell lung cancer

21 June 2018

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The noncatalytic amino terminus of mitogen-activated protein kinase phosphatase 1 directs nuclear targeting and serum response element transcriptional regulation

21 June 2018

1 reference

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Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847094

Abrogation of DUSP6 by hypermethylation in human pancreatic cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847094

Associations and interactions between Ets-1 and Ets-2 and coregulatory proteins, SRC-1, AIB1, and NCoR in breast cancer

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847094

Effect of common B-RAF and N-RAS mutations on global gene expression in melanoma cell lines

21 June 2018

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Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

21 June 2018

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EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

21 June 2018

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KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

21 June 2018

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EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

21 June 2018

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Mitogen-activated protein kinase phosphatase-3 is a tumor promoter target in initiated cells that express oncogenic Ras.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847094

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

21 June 2018

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847094

Structure and regulation of MAPK phosphatases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847094

Inducible expression of a MAP kinase phosphatase-3-GFP chimera specifically blunts fibroblast growth and ras-dependent tumor formation in nude mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847094

MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847094

Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847094

Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847094

The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847094

MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847094

A single mutation converts a novel phosphotyrosine binding domain into a dual-specificity phosphatase.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847094

Mkp3 is a negative feedback modulator of Fgf8 signaling in the mammalian isthmic organizer.

21 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ020

Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ020

A five-gene signature and clinical outcome in non-small-cell lung cancer

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ020

Mapping ERK2-MKP3 binding interfaces by hydrogen/deuterium exchange mass spectrometry

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20097731

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/CARCIN/BGQ020

1 reference

29 July 2017

1 reference

29 July 2017

1 reference