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Mouse models of PI(3,5)P2 deficiency with impaired lysosome function.
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Europe PubMed Central
PMC publication ID
4059992
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24359958%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
title
Mouse models of PI(3,5)P2 deficiency with impaired lysosome function
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4059992
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24359958%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
author
Guy M. Lenk
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4059992
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24359958%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
author name string
Miriam H Meisler
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
4059992
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24359958%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
language of work or name
English
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publication date
1 January 2014
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Europe PubMed Central
PMC publication ID
4059992
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24359958%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
published in
Methods in Enzymology
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Europe PubMed Central
PMC publication ID
4059992
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24359958%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
volume
534
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stated in
Europe PubMed Central
PMC publication ID
4059992
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24359958%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
page(s)
245-260
1 reference
stated in
Europe PubMed Central
PMC publication ID
4059992
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24359958%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
cites work
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PubMed Central
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In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.
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22 June 2018
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Congenital CNS hypomyelination in the Fig4 null mouse is rescued by neuronal expression of the PI(3,5)P(2) phosphatase Fig4.
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Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies
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Distinctive genetic and clinical features of CMT4J: a severe neuropathy caused by mutations in the PI(3,5)P₂ phosphatase FIG4.
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22 June 2018
Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J
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22 June 2018
The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice
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22 June 2018
PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome
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22 June 2018
ArPIKfyve regulates Sac3 protein abundance and turnover: disruption of the mechanism by Sac3I41T mutation causing Charcot-Marie-Tooth 4J disorder
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Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.
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22 June 2018
Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS.
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22 June 2018
VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse
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22 June 2018
Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration
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22 June 2018
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.
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reference URL
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22 June 2018
Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059992
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22 June 2018
Loss of autophagy in the central nervous system causes neurodegeneration in mice
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059992
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22 June 2018
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
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PubMed Central
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22 June 2018
Phosphoinositide 5-phosphatase Fig 4p is required for both acute rise and subsequent fall in stress-induced phosphatidylinositol 3,5-bisphosphate levels
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PubMed Central
reference URL
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22 June 2018
Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059992
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22 June 2018
A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059992
retrieved
22 June 2018
Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059992
retrieved
22 June 2018
Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059992
retrieved
22 June 2018
Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059992
retrieved
22 June 2018
Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059992
retrieved
22 June 2018
Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059992
retrieved
22 June 2018
Identifiers
DOI
10.1016/B978-0-12-397926-1.00014-7
1 reference
stated in
Europe PubMed Central
PMC publication ID
4059992
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24359958%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
PMC publication ID
4059992
1 reference
stated in
Europe PubMed Central
PMC publication ID
4059992
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24359958%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
PubMed publication ID
24359958
1 reference
stated in
Europe PubMed Central
PMC publication ID
4059992
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24359958%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
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