(Q33778054)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10570249%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

review article

1 reference

title

Pancreatic phospholipase A(2): new views on old issues (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10570249%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10570249%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

author name string

C Yuan

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10570249%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

language of work or name

English

0 references

publication date

1 November 1999

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10570249%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

number of pages

8

1 reference

Biochimica et Biophysica Acta

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10570249%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

volume

1441

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10570249%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

issue

2-3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10570249%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

page(s)

215-222

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10570249%20AND%20SRC:MED&resulttype=core&format=json

The growing phospholipase A2 superfamily of signal transduction enzymes

2 November 2019

cites work

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Three-dimensional structure and disulfide bond connections in bovine pancreatic phospholipase A2

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Structure of bovine pancreatic phospholipase A2 at 1.7 Å resolution

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7 January 2021

Structure of porcine pancreatic phospholipase A2 at 2.6 A resolution and comparison with bovine phospholipase A2

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7 January 2021

Methylation of histidine-48 in pancreatic phospholipase A2. Role of histidine and calcium ion in the catalytic mechanism

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7 January 2021

Expression of porcine pancreatic phospholipase A2. Generation of active enzyme by sequence-specific cleavage of a hybrid protein from Escherichia coli

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Phospholipase A2 engineering: design, synthesis, and expression of a gene for bovine (pro)phospholipase A2.

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A novel expression vector for high-level synthesis and secretion of foreign proteins in Escherichia coli: overproduction of bovine pancreatic phospholipase A2.

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7 January 2021

Interfacial catalysis by phospholipase A2: determination of the interfacial kinetic rate constants

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7 January 2021

Thermodynamic and kinetic basis of interfacial activation: resolution of binding and allosteric effects on pancreatic phospholipase A2 at zwitterionic interfaces

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7 January 2021

Solution structure of porcine pancreatic phospholipase A2 complexed with micelles and a competitive inhibitor

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7 January 2021

Structural analysis of phospholipase A2 from functional perspective. 1. Functionally relevant solution structure and roles of the hydrogen-bonding network

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7 January 2021

Phospholipase A2--a structural review

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Interfacial enzymology of glycerolipid hydrolases: lessons from secreted phospholipases A2.

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7 January 2021

Phospholipases: structural and functional motifs for working at an interface

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7 January 2021

The kinetics of interfacial catalysis by phospholipase A2 and regulation of interfacial activation: hopping versus scooting

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7 January 2021

Phospholipase A2 at the bilayer interface

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7 January 2021

Active site and catalytic mechanism of phospholipase A2

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7 January 2021

Crystal structure of bee-venom phospholipase A2 in a complex with a transition-state analogue

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7 January 2021

Crystal structure of cobra-venom phospholipase A2 in a complex with a transition-state analogue

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7 January 2021

X-ray structure of phospholipase A2 complexed with a substrate-derived inhibitor

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7 January 2021

Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate

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7 January 2021

Crystal structure of the complex of bovine pancreatic phospholipase A2 with the inhibitor 1-hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol,

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7 January 2021

Phospholipase A2 engineering. Structural and functional roles of the highly conserved active site residue aspartate-49.

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7 January 2021

The divalent cation is obligatory for the binding of ligands to the catalytic site of secreted phospholipase A2.

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7 January 2021

Catalytic significance of the specificity of divalent cations as KS* and kcat* cofactors for secreted phospholipase A2

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7 January 2021

Phospholipase A2 engineering. The structural and functional roles of aromaticity and hydrophobicity in the conserved phenylalanine-22 and phenylalanine-106 aromatic sandwich

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7 January 2021

Phospholipase A2 engineering. X-ray structural and functional evidence for the interaction of lysine-56 with substrates

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7 January 2021

Functional significance of the conformational dynamics of the N-terminal segment of secreted phospholipase A2 at the interface

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7 January 2021

Phospholipase A2 engineering. Probing the structural and functional roles of N-terminal residues with site-directed mutagenesis, X-ray, and NMR.

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7 January 2021

A structure-function study of bovine pancreatic phospholipase A2 using polymerized mixed liposomes

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7 January 2021

Roles of surface hydrophobic residues in the interfacial catalysis of bovine pancreatic phospholipase A2.

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7 January 2021

Phospholipase A2 engineering. Deletion of the C-terminus segment changes substrate specificity and uncouples calcium and substrate binding at the zwitterionic interface

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7 January 2021

Cationic residues 53 and 56 control the anion-induced interfacial k*cat activation of pancreatic phospholipase A2

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7 January 2021

The electrostatic basis for the interfacial binding of secretory phospholipases A2.

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7 January 2021

Docking phospholipase A2 on membranes using electrostatic potential-modulated spin relaxation magnetic resonance

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7 January 2021

Interfacial catalysis: the mechanism of phospholipase A2

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7 January 2021

Conformational changes in phospholipase A2 upon binding to micellar interfaces in the absence and presence of competitive inhibitors. A 1H and 15N NMR study

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7 January 2021

NMR structures of phospholipase A2 reveal conformational changes during interfacial activation

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7 January 2021

Changes in the structure of bovine phospholipase A2 upon micelle binding

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7 January 2021

Insight into the conformational dynamics of specific regions of porcine pancreatic phospholipase A2 from a time-resolved fluorescence study of a genetically inserted single tryptophan residue

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7 January 2021

Role of the N-terminus in the interaction of pancreatic phospholipase A2 with aggregated substrates. Properties and crystal structure of transaminated phospholipase A2

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7 January 2021

X-ray crystal structure determination and molecular dynamics simulation of prophospholipase A2 inhibited by amide-type substrate analogues

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7 January 2021

Phospholipase A2 engineering. Structural and functional roles of highly conserved active site residues tyrosine-52 and tyrosine-73

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7 January 2021

Function of the fully conserved residues Asp99, Tyr52 and Tyr73 in phospholipase A2.

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7 January 2021

Phospholipase A2 engineering. Structural and functional roles of the highly conserved active site residue aspartate-99

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7 January 2021

Site-directed mutagenesis and X-ray crystallography of two phospholipase A2 mutants: Y52F and Y73F

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7 January 2021

Crystal structure of the Y52F/Y73F double mutant of phospholipase A2: increased hydrophobic interactions of the phenyl groups compensate for the disrupted hydrogen bonds of the tyrosines

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7 January 2021

Structure and function of the catalytic site mutant Asp 99 Asn of phospholipase A2: absence of the conserved structural water

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7 January 2021

Incorporation of an unnatural amino acid in the active site of porcine pancreatic phospholipase A2. Substitution of histidine by 1,2,4-triazole-3-alanine yields an enzyme with high activity at acidic pH.

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7 January 2021

pH dependence of the reaction rate of p-bromophenacyl bromide and of the binding constants of Ca2+ and an amide-type substrate analog to bovine pancreatic phospholipase A2

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7 January 2021

Structural analysis of phospholipase A2 from functional perspective. 2. Characterization of a molten globule-like state induced by site-specific mutagenesis.

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7 January 2021

Porcine pancreatic phospholipase A2: sequence-specific 1H and 15N NMR assignments and secondary structure

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7 January 2021

Phospholipase A2 engineering. The roles of disulfide bonds in structure, conformational stability, and catalytic function.

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7 January 2021

Mechanism of adenylate kinase: site-directed mutagenesis versus X-ray and NMR.

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7 January 2021

Influence of size and polarity of residue 31 in porcine pancreatic phospholipase A2 on catalytic properties

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7 January 2021

The role of Asp-49 and other conserved amino acids in phospholipases A2 and their importance for enzymatic activity

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7 January 2021

Crystal structure of a porcine pancreatic phospholipase A2 mutant. A large conformational change caused by the F63V point mutation

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7 January 2021

Evidence for the involvement of tyrosine-69 in the control of stereospecificity of porcine pancreatic phospholipase A2

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7 January 2021

Activities of native and tyrosine-69 mutant phospholipases A2 on phospholipid analogues. A reevaluation of the minimal substrate requirements

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7 January 2021

Enhanced activity and altered specificity of phospholipase A2 by deletion of a surface loop

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7 January 2021

An extended binding pocket determines the polar head group specificity of porcine pancreatic phospholipase A2.

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7 January 2021

The importance of glycine-30 for enzymatic activity of phospholipase A2.

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7 January 2021