(Q33787932)

29 July 2017

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title

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? (English)

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29 July 2017

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Vander Heiden MG

1

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PubMed ID

10587660

29 July 2017

Thompson CB

series ordinal

2

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29 July 2017

1 December 1999

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29 July 2017

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29 July 2017

1

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29 July 2017

8

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29 July 2017

E209-16

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https://scigraph.springernature.com/pub.10.1038/70237

29 July 2017

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cites work

Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria.

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7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

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7 January 2021

Caspases: enemies within

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7 January 2021

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

7 January 2021

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

7 January 2021

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

1 reference

7 January 2021

Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

1 reference

7 January 2021

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

1 reference

7 January 2021

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

1 reference

7 January 2021

Translocation of apocytochrome c across the outer membrane of mitochondria

1 reference

7 January 2021

Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system.

1 reference

7 January 2021

Mitochondrial release of caspase-2 and -9 during the apoptotic process

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7 January 2021

The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signaling

1 reference

7 January 2021

Detection of pro-caspase-3 in cytosol and mitochondria of various tissues.

1 reference

7 January 2021

Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells

1 reference

7 January 2021

Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia

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7 January 2021

Molecular characterization of mitochondrial apoptosis-inducing factor

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7 January 2021

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

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7 January 2021

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

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7 January 2021

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

1 reference

7 January 2021

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

1 reference

7 January 2021

Release of cytochrome c and decrease of cytochrome c oxidase in Bax-expressing yeast cells, and prevention of these effects by coexpression of Bcl-xL

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7 January 2021

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

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7 January 2021

Bax directly induces release of cytochrome c from isolated mitochondria

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7 January 2021

The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition

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7 January 2021

Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange

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7 January 2021

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

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7 January 2021

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1 reference

7 January 2021

Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification

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7 January 2021

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death

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7 January 2021

Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux

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7 January 2021

Movement of Bax from the cytosol to mitochondria during apoptosis

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7 January 2021

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

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7 January 2021

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1 reference

7 January 2021

Bax-independent inhibition of apoptosis by Bcl-XL.

1 reference

7 January 2021

Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms

1 reference

7 January 2021

Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death

1 reference

7 January 2021

Interaction between the C. elegans cell-death regulators CED-9 and CED-4.

1 reference

7 January 2021

Interaction and regulation of subcellular localization of CED-4 by CED-9

1 reference

7 January 2021

Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex

1 reference

7 January 2021

Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1 reference

7 January 2021

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

1 reference

7 January 2021

Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2.

1 reference

7 January 2021

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

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7 January 2021

Bcl-x(L) forms an ion channel in synthetic lipid membranes.

1 reference

7 January 2021

Channel formation by antiapoptotic protein Bcl-2.

1 reference

7 January 2021

Inhibition of Bax channel-forming activity by Bcl-2

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7 January 2021

Ion channel activity of the BH3 only Bcl-2 family member, BID.

1 reference

7 January 2021

Cytoprotection by Bcl-2 requires the pore-forming alpha5 and alpha6 helices

1 reference

7 January 2021

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

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7 January 2021

Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

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7 January 2021

Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations

1 reference

7 January 2021

Regulation of apoptosis by BH3 domains in a cell-free system

1 reference

7 January 2021

Secondary structure of the pore-forming colicin A and its C-terminal fragment. Experimental fact and structure prediction

1 reference

7 January 2021

Simultaneous release of adenylate kinase and cytochrome c in cell death

1 reference

7 January 2021

Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis

1 reference

7 January 2021

Investigation of bax-induced release of cytochrome c from yeast mitochondria permeability of mitochondrial membranes, role of VDAC and ATP requirement

1 reference

7 January 2021

The central executioners of apoptosis: caspases or mitochondria?

1 reference

7 January 2021

The mitochondrial permeability transition.

1 reference

7 January 2021

Mitochondrial control of nuclear apoptosis.

1 reference

7 January 2021

Commitment to apoptosis by GD3 ganglioside depends on opening of the mitochondrial permeability transition pore.

1 reference

7 January 2021

Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition

1 reference

7 January 2021

Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis.

1 reference

7 January 2021

Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions

1 reference

7 January 2021

Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence

1 reference

7 January 2021

Mitochondrial permeability transition and swelling can occur reversibly without inducing cell death in intact human cells

1 reference

7 January 2021

From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state

1 reference

7 January 2021

The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release

1 reference

7 January 2021

The molecular structure of mitochondrial contact sites. Their role in regulation of energy metabolism and permeability transition

1 reference

7 January 2021

Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism

1 reference

7 January 2021

Porin interaction with hexokinase and glycerol kinase: Metabolic microcompartmentation at the outer mitochondrial membrane

1 reference

7 January 2021

Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

1 reference

7 January 2021

The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins

1 reference

7 January 2021

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

1 reference

7 January 2021

Ultrastructural bases for metabolically linked mechanical activity in mitochondria. I. Reversible ultrastructural changes with change in metabolic steady state in isolated liver mitochondria

1 reference

7 January 2021

Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

1 reference

7 January 2021

Mitochondrial transport of cations: channels, exchangers, and permeability transition.

1 reference

7 January 2021

The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism

1 reference

7 January 2021

VDAC channels mediate and gate the flow of ATP: implications for the regulation of mitochondrial function

1 reference

7 January 2021

Regulation of metabolite flux through voltage-gating of VDAC channels.

1 reference

7 January 2021

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1 reference

7 January 2021

Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak

1 reference

7 January 2021

Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death

1 reference

7 January 2021

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

1 reference

7 January 2021

Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome c

1 reference

7 January 2021

The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event

1 reference

7 January 2021

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

1 reference

7 January 2021

Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis

1 reference

7 January 2021

A function for lipoxygenase in programmed organelle degradation

1 reference

7 January 2021

Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis

1 reference

7 January 2021

Identifiers

DOI

10.1038/70237

1 reference

PubMed ID

10587660

Dimensions Publication ID

29 July 2017

0 references

1 reference

PubMed ID

10587660