(Q33793242)

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Molecular investigations on the nicotinic acetylcholine receptor: conformational mapping and dynamic exploration using photoaffinity labeling

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

1 reference

Europe PubMed Central

Molecular investigations on the nicotinic acetylcholine receptor: conformational mapping and dynamic exploration using photoaffinity labeling (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

author name string

Kotzyba-Hibert F

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Grutter T

2

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Goeldner M

3

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

publication date

1 August 1999

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Molecular Neurobiology

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

20

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

45-59

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

https://scigraph.springernature.com/pub.10.1007/bf02741364

0 references

Molecular dissection of subunit interfaces in the acetylcholine receptor. Identification of residues that determine agonist selectivity

1 reference

https://api.crossref.org/works/10.1007%2FBF02741364

21 January 2018

A hydrophobic inhibitor of the nicotinic acetylcholine receptor acts on the resting state.

1 reference

https://api.crossref.org/works/10.1007%2FBF02741364

21 January 2018

Identification of acetylcholine receptor channel-lining residues in the M1 segment of the beta-subunit.

1 reference

https://api.crossref.org/works/10.1007%2FBF02741364

21 January 2018

Allosteric receptors after 30 years

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple sites of action for noncompetitive blockers on acetylcholine receptor rich membrane fragments from torpedo marmorata

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotinic acetylcholine receptor labeled with a tritiated, photoactivatable agonist: a new tool for investigating the functional, activated state

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Congenital myasthenic syndromes: experiments of nature

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthetic peptides and four-helix bundle proteins as model systems for the pore-forming structure of channel proteins. I. Transmembrane segment M2 of the nicotinic cholinergic receptor channel is a key pore-lining structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotinic receptors in the development and modulation of CNS synapses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotinic acetylcholine receptor probed with a photoactivatable agonist: improved labeling specificity by addition of CeIV/glutathione. Extension to laser flash photolabeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Probing the structure of the nicotinic acetylcholine receptor ion channel with the uncharged photoactivable compound -3H-diazofluorene

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel photoactivatable agonist of the nicotinic acetylcholine receptor of potential use for exploring the functional activated state

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholine receptor channel imaged in the open state

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time-resolved photolabeling by quinacrine azide of a noncompetitive inhibitor site of the nicotinic acetylcholine receptor in a transient, agonist-induced state.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Location of subunits within the acetylcholine receptor by electron image analysis of tubular crystals from Torpedo marmorata

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist binding site of Torpedo electric tissue nicotinic acetylcholine receptor. A negatively charged region of the delta subunit within 0.9 nm of the alpha subunit binding site disulfide

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-Conotoxins, small peptide probes of nicotinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A stopped-flow apparatus for photoaffinity labeling studies in the milliseconds time range. Application in investigations of the nicotinic acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

d-Tubocurarine binding sites are located at alpha-gamma and alpha-delta subunit interfaces of the nicotinic acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of tryptophan 55 as the primary site of [3H]nicotine photoincorporation in the gamma-subunit of the Torpedo nicotinic acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topography of toxin-acetylcholine receptor complexes by using photoactivatable toxin derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino acids of the Torpedo marmorata acetylcholine receptor alpha subunit labeled by a photoaffinity ligand for the acetylcholine binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complete mRNA coding sequence of the acetylcholine binding alpha-subunit of Torpedo marmorata acetylcholine receptor: a model for the transmembrane organization of the polypeptide chain

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional significance of aromatic amino acids from three peptide loops of the alpha 7 neuronal nicotinic receptor site investigated by site-directed mutagenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of determinants of alpha-conotoxin M1 selectivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A molecular view of neurotransmitter receptors and ionic channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photoactivatable agonist of the nicotinic acetylcholine receptor: potential probe to characterize the structural transitions of the acetylcholine binding site in different states of the receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of binding of [3H]acetylcholine and [3H]carbamoylcholine to Torpedo postsynaptic membranes: slow conformational transitions of the cholinergic receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of neurotransmitter receptor desensitization by protein phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a local anesthetic binding site in nicotinic post-synaptic membranes isolated from Torpedo marmorata electric tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nucleotide and deduced amino acid sequences of Torpedo californica acetylcholine receptor gamma subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholine receptor channel structure probed in cysteine-substitution mutants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the noncompetitive antagonist-binding site of the Torpedo nicotinic acetylcholine receptor. [3H]meproadifen mustard reacts selectively with alpha-subunit Glu-262

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of acetylcholine receptor channel-lining residues in the M1 segment of the alpha-subunit.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topological disposition of Cys 222 in the alpha-subunit of nicotinic acetylcholine receptor analyzed by fluorescence-quenching and electron paramagnetic resonance measurements

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural homology of Torpedo californica acetylcholine receptor subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric transitions of the acetylcholine receptor probed at the amino acid level with a photolabile cholinergic ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Desensitization at the frog neuromuscular junction: a biphasic process

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fast Kinetic Studies on the Interaction of a Fluorescent Agonist with the Membrane-Bound Acetylcholine Receptor from Torpedo marmorata

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Explorations of the nicotinic acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time-resolved photolabeling by the noncompetitive blocker chlorpromazine of the acetylcholine receptor in its transiently open and closed ion channel conformations

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The emerging three-dimensional structure of a receptor. The nicotinic acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a new component of the agonist binding site of the nicotinic alpha 7 homooligomeric receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifying the lipid-protein interface of the Torpedo nicotinic acetylcholine receptor: secondary structure implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conserved tyrosines in the alpha subunit of the nicotinic acetylcholine receptor stabilize quaternary ammonium groups of agonists and curariform antagonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The contributions of aspartyl residues in the acetylcholine receptor gamma and delta subunits to the binding of agonists and competitive antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping the alpha-subunit site photolabeled by the noncompetitive inhibitor [3H]quinacrine azide in the active state of the nicotinic acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gamma- and delta-subunits regulate the affinity and the cooperativity of ligand binding to the acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional effects on the acetylcholine receptor of multiple mutations of gamma Asp174 and delta Asp180

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photoaffinity labeling of the acetylcholine binding sites on the nicotinic receptor by an aryldiazonium derivative

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular modelling of the nicotinic acetylcholine receptor transmembrane region in the open state

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An analog of lophotoxin reacts covalently with Tyr190 in the alpha-subunit of the nicotinic acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Covalent labeling of functional states of the acetylcholine receptor. Effects of antagonists on the receptor conformation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The multiple phenotypes of allosteric receptor mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric nicotinic receptors, human pathologies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the transient agonist-triggered state of the acetylcholine receptor rapidly labeled by the noncompetitive blocker [3H]chlorpromazine: additional evidence for the open channel conformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid laser flash photoaffinity labeling of binding sites for a noncompetitive inhibitor of the acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of amino acids contributing to high and low affinity d-tubocurarine sites in the Torpedo nicotinic acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new class of photoactivatable and cleavable derivatives of neurotoxin II from Naja naja oxiana. Synthesis, characterisation, and application for affinity labelling of the nicotinic acetylcholine receptor from Torpedo californica.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic noncompetitive antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of a glutamate-receptor ligand-binding core in complex with kainate

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stratification of the channel domain in neurotransmitter receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinacrine and ethidium bromide bind the same locus on the nicotinic acetylcholine receptor from Torpedo californica

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinacrine noncompetitive inhibitor binding site localized on the Torpedo acetylcholine receptor in the open state

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the agonist-binding site of the nicotinic acetylcholine receptor. [3H]acetylcholine mustard identifies residues in the cation-binding subsite

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity label

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transmembrane region of the nicotinic acetylcholine receptor: is it an all-helix bundle?

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the beta and delta chains

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid kinetics of agonist binding and permeability response analyzed in parallel on acetylcholine receptor rich membranes from Torpedo marmorata.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal nicotinic receptors: molecular organization and regulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/10595872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF02741364

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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