(Q33805404)

29 July 2017

title

Comparative genomics allowed the identification of drug targets against human fungal pathogens (English)

1 reference

Ortholog(s) have cell division site, cytosol, nucleolus localization

29 July 2017

main subject

1 reference

5 February 2019

Tubulin alpha-1 subunit

1 reference

Putative polyadenylate-binding protein

5 February 2019

1 reference

Putative phosphatidate cytidylyltransferase

5 February 2019

1 reference

Alpha-1,6 mannosyltransferase subunit with a predicted role in N-linked protein glycosylation

5 February 2019

1 reference

Ortholog(s) have nucleolus localization

5 February 2019

1 reference

Ortholog(s) have DNA-directed DNA polymerase activity, double-stranded DNA binding, single-stranded DNA binding activity

5 February 2019

1 reference

Parvulin-like peptidyl-prolyl cis-trans isomerase

5 February 2019

1 reference

5 February 2019

Putative protein kinase

1 reference

Eukaryotic translation initiation factor 3 subunit G

5 February 2019

1 reference

Putative secretory-pathway GDP dissociation inhibitor

5 February 2019

1 reference

Carbon catabolite repressor A

5 February 2019

1 reference

Putative cell wall biosynthesis protein

5 February 2019

1 reference

Putative protein transport protein

5 February 2019

1 reference

Putative bifunctional tryptophan synthase

5 February 2019

1 reference

Ortholog(s) have chromatin binding activity and role in DNA replication initiation, pre-replicative complex assembly involved in nuclear cell cycle DNA replication, rRNA processing, response to drug

5 February 2019

1 reference

Ortholog(s) have phosphoadenylyl-sulfate reductase (thioredoxin) activity

5 February 2019

1 reference

Putative inorganic diphosphatase

6 February 2019

1 reference

Ortholog(s) have phosphatidylcholine transporter activity, phosphatidylinositol transporter activity

6 February 2019

1 reference

Putative aureobasidin resistance protein

6 February 2019

1 reference

Ortholog(s) have cytosol localization

6 February 2019

1 reference

Putative sterol 24-C-methyltransferase with a predicted role in ergosterol biosynthesis

6 February 2019

1 reference

Eukaryotic translation initiation factor 3 subunit C

6 February 2019

1 reference

Putative class II chitin synthase

6 February 2019

1 reference

Ortholog(s) have role in cellular response to drug and nucleolus localization

6 February 2019

1 reference

Ortholog(s) have glycylpeptide N-tetradecanoyltransferase activity, role in establishment of cell polarity, replicative cell aging and cytosol localization

6 February 2019

1 reference

Putative S-adenosyl-methionine-sterol-C methyltransferase

6 February 2019

1 reference

Ortholog(s) have role in cellular response to biotic stimulus, cellular response to pH, entry into host and filamentous growth of a population of unicellular organisms in response to biotic stimulus, more

6 February 2019

1 reference

Ortholog(s) have unfolded protein binding activity

6 February 2019

1 reference

Ortholog(s) have ribose phosphate diphosphokinase activity and role in 5-phosphoribose 1-diphosphate biosynthetic process, cellular response to drug, cytokinesis, fungal-type cell wall organization

6 February 2019

1 reference

Saccharopine dehydrogenase

6 February 2019

1 reference

GDP-mannose pyrophosphorylase, which catalyses the synthesis of GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis

6 February 2019

1 reference

Putative thioredoxin reductase

6 February 2019

1 reference

Ortholog(s) have adenosylmethionine decarboxylase activity, role in spermidine biosynthetic process, spermine biosynthetic process and cytosol, nucleus localization

6 February 2019

1 reference

Ortholog(s) have nucleus localization

6 February 2019

1 reference

homoserine O-acetyltransferase

6 February 2019

1 reference

Putative alpha-1,2-mannosyltransferase with a predicted role in protein glycosylation

6 February 2019

1 reference

Putative glucosamine 6-phosphate N-acetyltransferase

6 February 2019

1 reference

Mitochondrial bifunctional enzyme with N-acetyl-gamma-glutamyl-phosphate reductase and acetylglutamate kinase activity, catalyzes the second and third step in arginine biosynthesis

6 February 2019

1 reference

Putative imidazoleglycerol-phosphate dehydratase

6 February 2019

1 reference

Ortholog(s) have mitochondrion targeting sequence binding, protein channel activity and role in conidium formation, hyphal growth, protein import into mitochondrial matrix, protein import into mitochondrial outer membrane

6 February 2019

1 reference

Ortholog(s) have glutamine-fructose-6-phosphate transaminase (isomerizing) activity

6 February 2019

1 reference

Ortholog(s) have role in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and nucleolus localization

6 February 2019

1 reference

Ortholog(s) have mRNA binding activity, role in mRNA splice site selection and U1 snRNP, U2-type prespliceosome, cytosol localization

6 February 2019

1 reference

Putative 1,3-beta-glucan synthase catalytic subunit, major subunit of glucan synthase

6 February 2019

1 reference

GTP-Binding nuclear protein Ran

6 February 2019

1 reference

ATP phosphoribosyltransferase

6 February 2019

1 reference

Ortholog(s) have stearoyl-CoA 9-desaturase activity

6 February 2019

1 reference

Putative acetyl-coenzyme A acetyltransferase

6 February 2019

1 reference

6 February 2019

0 references

1 reference

Ana Karina R Abadio

1

1 reference

29 July 2017

Erika S Kioshima

2

1 reference

29 July 2017

Marcus M Teixeira

3

1 reference

29 July 2017

Natalia F Martins

4

1 reference

29 July 2017

Bernard Maigret

5

1 reference

29 July 2017

Maria Sueli S Felipe

6

1 reference

29 July 2017

language of work or name

English

0 references

publication date

27 January 2011

1 reference

29 July 2017

1 reference

29 July 2017

volume

12

1 reference

29 July 2017

page(s)

75

1 reference

Insights into the specificity of thioredoxin reductase-thioredoxin interactions. A structural and functional investigation of the yeast thioredoxin system

29 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

New triazoles and echinocandins: mode of action, in vitro activity and mechanisms of resistance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Homology modeling in drug discovery: current trends and applications

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Phylogenetic analysis reveals a high level of speciation in the Paracoccidioides genus

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Clinical relevance of the pharmacokinetic interactions of azole antifungal drugs with other coadministered agents

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Liposomal amphotericin B: a review of its use as empirical therapy in febrile neutropenia and in the treatment of invasive fungal infections

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

SNUGB: a versatile genome browser supporting comparative and functional fungal genomics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

The putative alpha-1,2-mannosyltransferase AfMnt1 of the opportunistic fungal pathogen Aspergillus fumigatus is required for cell wall stability and full virulence

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Comparative genomic assessment of novel broad-spectrum targets for antibacterial drugs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

In search of the holy grail of antifungal therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Mining predicted essential genes of Brugia malayi for nematode drug targets

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Advances in antifungal therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Essential gene identification and drug target prioritization in Aspergillus fumigatus

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Transcriptional profiles of the human pathogenic fungus Paracoccidioides brasiliensis in mycelium and yeast cells.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

The spatial organization of lipid synthesis in the yeast Saccharomyces cerevisiae derived from large scale green fluorescent protein tagging and high resolution microscopy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Thioredoxin reductase is essential for viability in the fungal pathogen Cryptococcus neoformans

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Structure of Kre2p/Mnt1p: a yeast alpha1,2-mannosyltransferase involved in mannoprotein biosynthesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Accelerating comparative genomics using parallel computing

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

MrBayes 3: Bayesian phylogenetic inference under mixed models

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Regulation of gene expression by ambient pH in filamentous fungi and yeasts

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Active site mapping and substrate channeling in the sterol methyltransferase pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Trends in mortality due to invasive mycotic diseases in the United States, 1980-1997.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Thioredoxin reductase two modes of catalysis have evolved

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Physiological functions of thioredoxin and thioredoxin reductase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Candida albicans RIM101 pH response pathway is required for host-pathogen interactions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Formation and properties of mixed disulfides between thioredoxin reductase from Escherichia coli and thioredoxin: evidence that cysteine-138 functions to initiate dithiol-disulfide interchange and to accept the reducing equivalent from reduced flavi

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Molecular analysis of CaMnt1p, a mannosyl transferase important for adhesion and virulence of Candida albicans

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

The Ktr1p, Ktr3p, and Kre2p/Mnt1p mannosyltransferases participate in the elaboration of yeast O- and N-linked carbohydrate chains

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Localization and targeting of the Saccharomyces cerevisiae Kre2p/Mnt1p alpha 1,2-mannosyltransferase to a medial-Golgi compartment

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Sterol methylation in Saccharomyces cerevisiae

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterol

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

The rapid generation of mutation data matrices from protein sequences

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Yeast KRE2 defines a new gene family encoding probable secretory proteins, and is required for the correct N-glycosylation of proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Yeast glycoprotein biosynthesis: MNT1 encodes an alpha-1,2-mannosyltransferase involved in O-glycosylation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

[Emerging invasive fungal infections].

28 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2164-12-75

Lipid formulations of amphotericin B: clinical efficacy and toxicities

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2164-12-75

Comparison of the physicochemical, antifungal, and toxic properties of two liposomal amphotericin B products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2164-12-75

Amphotericin B in poly(lactic-co-glycolic acid) (PLGA) and dimercaptosuccinic acid (DMSA) nanoparticles against paracoccidioidomycosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2164-12-75

Thioredoxin reductase is essential for the survival of Plasmodium falciparum erythrocytic stages

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2164-12-75

Transcriptional regulation of the Staphylococcus aureus thioredoxin and thioredoxin reductase genes in response to oxygen and disulfide stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2164-12-75

Thioredoxin reductase-dependent inhibition of MCB cell cycle box activity in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2164-12-75

Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2164-12-75

Crystal structure of Saccharomyces cerevisiae cytoplasmic thioredoxin reductase Trr1 reveals the structural basis for species-specific recognition of thioredoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2164-12-75

Overexpression, purification, and stereochemical studies of the recombinant (S)-adenosyl-L-methionine: delta 24(25)- to delta 24(28)-sterol methyl transferase enzyme from Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2164-12-75

Molecular probing of the Saccharomyces cerevisiae sterol 24-C methyltransferase reveals multiple amino acid residues involved with C2-transfer activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2164-12-75

Crystal structure of Arabidopsis thaliana NADPH dependent thioredoxin reductase at 2.5 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2164-12-75

How to improve R&D productivity: the pharmaceutical industry's grand challenge

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Enzyme redesign and interactions of substrate analogues with sterol methyltransferase to understand phytosterol diversity, reaction mechanism and the nature of the active site

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042012

Deletion of the Saccharomyces cerevisiae TRR1 gene encoding thioredoxin reductase inhibits p53-dependent reporter gene expression

30 October 2018

1 reference

12 December 2020

Site-Directed Mutagenesis of the Sterol Methyl Transferase Active Site from Saccharomyces cerevisiae Results in Formation of Novel 24-Ethyl Sterols

1 reference

12 December 2020

Functional characterization of the Candida albicans MNT1 mannosyltransferase expressed heterologously in Pichia pastoris

1 reference

12 December 2020

Structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase

1 reference

12 December 2020

Identifiers

DOI

10.1186/1471-2164-12-75

1 reference

Dimensions Publication ID

29 July 2017

1 reference

https://scigraph.springernature.com/pub.10.1186/1471-2164-12-75

9 September 2019

1 reference

29 July 2017

1 reference