(Q33810376)

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Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats?

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Europe PubMed Central

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29 July 2017

Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats? (English)

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Europe PubMed Central

PubMed publication ID

29 July 2017

author name string

Miroslav M Savić

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Samarpan Majumder

2

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29 July 2017

Shengming Huang

3

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29 July 2017

Rahul V Edwankar

4

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29 July 2017

Roman Furtmüller

5

1 reference

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29 July 2017

Srdan Joksimović

6

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29 July 2017

Terry Clayton

7

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29 July 2017

Joachim Ramerstorfer

8

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29 July 2017

Marija M Milinković

9

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Europe PubMed Central

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29 July 2017

Bryan L Roth

10

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Europe PubMed Central

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29 July 2017

Werner Sieghart

11

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29 July 2017

James M Cook

12

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29 July 2017

publication date

13 January 2010

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Europe PubMed Central

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29 July 2017

Progress in Neuro-Psychopharmacology & Biological Psychiatry

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29 July 2017

34

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29 July 2017

2

1 reference

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29 July 2017

376-386

1 reference

Europe PubMed Central

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29 July 2017

Target site occupancy: emerging generalizations from clinical and preclinical studies

1 reference

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Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models

1 reference

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The differential role of alpha1- and alpha5-containing GABA(A) receptors in mediating diazepam effects on spontaneous locomotor activity and water-maze learning and memory in rats

1 reference

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NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy

1 reference

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Pharmacological Properties of DOV 315,090, an ocinaplon metabolite

1 reference

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PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats

1 reference

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Morris water maze: procedures for assessing spatial and related forms of learning and memory

1 reference

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Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists?

1 reference

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Pharmacodynamic and pharmacokinetic effects of TPA023, a GABA(A) alpha(2,3) subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers.

1 reference

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The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors

1 reference

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28 July 2018

GABA-based therapeutic approaches: GABAA receptor subtype functions

1 reference

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28 July 2018

GABA-A receptors: a viable target for novel anxiolytics?

1 reference

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28 July 2018

Evidence-based guidelines for the pharmacological treatment of anxiety disorders: recommendations from the British Association for Psychopharmacology

1 reference

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28 July 2018

Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator.

1 reference

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28 July 2018

Positioning of the alpha-subunit isoforms confers a functional signature to gamma-aminobutyric acid type A receptors.

1 reference

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28 July 2018

GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain.

1 reference

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28 July 2018

Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety.

1 reference

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28 July 2018

Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human [...]

1 reference

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28 July 2018

Endogenous [3H]flunitrazepam binding in human embryonic kidney cell line 293.

1 reference

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28 July 2018

Diazepam impairs acquisition but not performance in the Morris water maze.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859624

28 July 2018

The effect of subunit composition of rat brain GABAA receptors on channel function

1 reference

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Identification of receptor domains that modify ligand binding to 5-hydroxytryptamine2 and 5-hydroxytryptamine1c serotonin receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859624

28 July 2018

A single histidine in GABAA receptors is essential for benzodiazepine agonist binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859624

28 July 2018

Research in anxiety disorders: from the bench to the bedside

1 reference

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World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders - first revision

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Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands.

1 reference

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Molecular basis for the GABAA receptor-mediated tonic inhibition in rat somatosensory cortex.

1 reference

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Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.

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Bidirectional effects of benzodiazepine binding site ligands in the elevated plus-maze: differential antagonism by flumazenil and beta-CCt

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Requirement of alpha5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice.

1 reference

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Simple and sensitive liquid chromatography/tandem mass spectrometry method for the determination of diazepam and its major metabolites in rat cerebrospinal fluid

1 reference

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GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem.

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Molecular and neuronal substrate for the selective attenuation of anxiety.

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Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

1 reference

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Testing the NMDA, long-term potentiation, and cholinergic hypotheses of spatial learning.

1 reference

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Ethopharmacological analysis of rat behavior on the elevated plus-maze.

1 reference

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benzodiazepine site inverse agonists and locomotor activity in rats: bimodal and biphasic influence

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074611

12 December 2020

based on heuristic

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Identifiers

10.1016/J.PNPBP.2010.01.004

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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