(Q33815368)

English

Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21304887%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21304887%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

0 references

neurodegeneration

1 reference

based on heuristic

inferred from title

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21304887%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

author name string

Ya-Chu Chang

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21304887%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Wan-Tzu Hung

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21304887%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Yun-Chin Chang

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21304887%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Henry C Chang

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21304887%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Chia-Lin Wu

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21304887%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Ann-Shyn Chiang

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21304887%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

George R Jackson

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21304887%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

publication date

3 February 2011

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21304887%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21304887%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21304887%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21304887%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

e1001288

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21304887%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

copyright license

Creative Commons Attribution 4.0 International

3 February 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3033380/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Enhanced ATPase activities as a primary defect of mutant valosin-containing proteins that cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Valosin containing protein associated inclusion body myopathy: abnormal vacuolization, autophagy and cell fusion in myoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Valosin-containing protein disease: inclusion body myopathy with Paget's disease of the bone and fronto-temporal dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

VCP disease associated with myopathy, Paget disease of bone and frontotemporal dementia: review of a unique disorder

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Mitochondria--a nexus for aging, calorie restriction, and sirtuins?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Specific requirement of NMDA receptors for long-term memory consolidation in Drosophila ellipsoid body

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Frontotemporal lobar degeneration with ubiquitin-positive inclusions: a molecular genetic update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Unfolded protein response in a Drosophila model for retinal degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Pathological consequences of VCP mutations on human striated muscle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

p97: The cell's molecular purgatory?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Drosophila as a model for human neurodegenerative disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Copper homoeostasis in Drosophila melanogaster S2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

ATPase activity of p97-valosin-containing protein (VCP). D2 mediates the major enzyme activity, and D1 contributes to the heat-induced activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

AAA+ superfamily ATPases: common structure--diverse function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Structure of the AAA ATPase p97

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Glutamate receptor expression regulates quantal size and quantal content at the Drosophila neuromuscular junction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

p47 is a cofactor for p97-mediated membrane fusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Production and utilization of acetate in mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Isolation and characterization of flightless mutants in Drosophila melanogaster

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033380

4 July 2018

Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1001288

21 January 2018

Transgenic expression of inclusion body myopathy associated mutant p97/VCP causes weakness and ubiquitinated protein inclusions in mice.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1001288

21 January 2018

TER94, a Drosophila homolog of the membrane fusion protein CDC48/p97, is accumulated in nonproliferating cells: in the reproductive organs and in the brain of the imago

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1001288

21 January 2018

The receptor tyrosine kinase gene linotte is required for neuronal pathway selection in the Drosophila mushroom bodies.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1001288

21 January 2018

Endoplasmic reticulum stress compromises the ubiquitin-proteasome system

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1001288

21 January 2018

Multifunctional roles of the conserved Arg residues in the second region of homology of p97/valosin-containing protein

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1001288

21 January 2018

The contribution of Shaker K+ channels to the information capacity of Drosophila photoreceptors.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1001288

21 January 2018

Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1001288

21 January 2018

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1001288

21 January 2018

Clinical outcome in 19 French and Spanish patients with valosin-containing protein myopathy associated with Paget's disease of bone and frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1001288

21 January 2018

A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1001288

21 January 2018

Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1001288

21 January 2018

Blinded by the light

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1001288

21 January 2018

Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21304887

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential activation requirements associated with stimulation of T cells via different epitopes of CD3

1 reference

https://pubmed.ncbi.nlm.nih.gov/21304887

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Major Conformational Change in p97 AAA ATPase upon ATP Binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/21304887

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PGEN.1001288

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21304887%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21304887%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21304887%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q33815368&oldid=2165530296"