(Q33815474)

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Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: a novel pathway for cancer chemoprevention

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scholarly article

1 reference

Europe PubMed Central

29 July 2017

Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: a novel pathway for cancer chemoprevention (English)

1 reference

Europe PubMed Central

29 July 2017

author name string

Murugesan Velayutham

1

1 reference

Europe PubMed Central

29 July 2017

Rajendra B Muthukumaran

2

1 reference

Europe PubMed Central

29 July 2017

Joe Z Sostaric

3

1 reference

Europe PubMed Central

29 July 2017

John McCraken

4

1 reference

Europe PubMed Central

29 July 2017

James C Fishbein

5

1 reference

Europe PubMed Central

29 July 2017

Jay L Zweier

6

1 reference

Europe PubMed Central

29 July 2017

publication date

6 July 2007

1 reference

Europe PubMed Central

29 July 2017

Free Radical Biology and Medicine

1 reference

Europe PubMed Central

29 July 2017

43

1 reference

Europe PubMed Central

29 July 2017

7

1 reference

Europe PubMed Central

29 July 2017

1076-1085

1 reference

Europe PubMed Central

29 July 2017

Superoxide released into the mitochondrial matrix

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Cell signaling. H2O2, a necessary evil for cell signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Differential effects of the oxidized metabolites of oltipraz on the activation of CCAAT/enhancer binding protein-beta and NF-E2-related factor-2 for GSTA2 gene induction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Hydrogen peroxide: a signaling messenger

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Modulation of apoptosis by cancer chemopreventive agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Nrf2 as a novel molecular target for chemoprevention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Role of peroxidases in Parkinson disease: a hypothesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Cancer chemopreventive oltipraz generates superoxide anion radical

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Oxidative lipidomics of apoptosis: redox catalytic interactions of cytochrome c with cardiolipin and phosphatidylserine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Complex III releases superoxide to both sides of the inner mitochondrial membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Detection of reactive oxygen and nitrogen species by EPR spin trapping

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Cytochrome c, an ideal antioxidant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Topology of superoxide production from different sites in the mitochondrial electron transport chain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Antioxidants and oxidants regulated signal transduction pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Cancer chemoprevention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

A review of cancer chemopreventive agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Effects of extrinsic imidazole ligation on the molecular and electronic structure of cytochrome c

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Inhibition of ERK and p38 MAP kinases inhibits binding of Nrf2 and induction of GCS genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Effect of heme iron valence state on the conformation of cytochrome c and its association with membrane interfaces. A CD and EPR investigation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Development of cancer chemopreventive agents: oltipraz as a paradigm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Cellular kinetics of induction by oltipraz and its keto derivative of detoxication enzymes in human colon adenocarcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Oltipraz stimulates the transcription of the manganese superoxide dismutase gene in rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Chemoprevention by inducers of carcinogen detoxication enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Isolation of cDNAs representing dithiolethione-responsive genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Catalytic metals, ascorbate and free radicals: combinations to avoid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

The appearance of transient species of cytochrome c upon rapid oxidation or reduction at alkaline pH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Reduction of ferricytochrome c by dithionite ion: electron transfer by parallel adjacent and remote pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Inhibition by dietary oltipraz of experimental intestinal carcinogenesis induced by azoxymethane in male F344 rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

Effect of oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] on azoxymethane-induced biochemical changes related to early colon carcinogenesis in male F344 rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

The EPR of low spin heme complexes Relation of the τ2g hole model to the directional properties of the g tensor, and a new method for calculating the ligand field parameters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

The reaction between the superoxide anion radical and cytochrome c

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

4 July 2018

A novel metabolic pathway of melatonin: oxidation by cytochrome C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

30 October 2018

Glutathione-mediated formation of oxygen free radicals by the major metabolite of oltipraz

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

30 October 2018

Phase 2 enzyme induction by the major metabolite of oltipraz

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

30 October 2018

Evidence for the role of a peroxidase compound I-type intermediate in the oxidation of glutathione, NADH, ascorbate, and dichlorofluorescin by cytochrome c/H2O2. Implications for oxidative stress during apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

30 October 2018

Thiolytic chemistry of alternative precursors to the major metabolite of the cancer chemopreventive oltipraz

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

30 October 2018

Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

30 October 2018

Oltipraz chemoprevention trial in Qidong, People's Republic of China: results of urine genotoxicity assays as related to smoking habits.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

30 October 2018

Chemopreventive activity of oltipraz.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

30 October 2018

Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

30 October 2018

Chemopreventive effect of oltipraz during different stages of experimental colon carcinogenesis induced by azoxymethane in male F344 rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073605

30 October 2018

Comparison of the metabolism of oltipraz in the mouse, rat and monkey and in man. Distribution of the metabolites in each species

1 reference

https://pubmed.ncbi.nlm.nih.gov/17761303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome c-catalyzed membrane lipid peroxidation by hydrogen peroxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/17761303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones

1 reference

https://pubmed.ncbi.nlm.nih.gov/17761303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of Cu,Zn superoxide dismutase with hydrogen sulfide

1 reference

https://pubmed.ncbi.nlm.nih.gov/17761303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for thiol-dependent production of oxygen radicals by 4-methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione (oltipraz) and 3H-1,2-dithiole-3-thione: possible relevance to the anticarcinogenic properties of 1,2-dithiole-3-thiones

1 reference

https://pubmed.ncbi.nlm.nih.gov/17761303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oltipraz chemoprevention trial in Qidong, People's Republic of China: study design and clinical outcomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17761303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oltipraz chemoprevention trial in Qidong, People's Republic of China: modulation of serum aflatoxin albumin adduct biomarkers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17761303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A bridge to control

1 reference

https://pubmed.ncbi.nlm.nih.gov/17761303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of dithiolethiones with better chemopreventive properties than oltipraz

1 reference

https://pubmed.ncbi.nlm.nih.gov/17761303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Conformational Change in Cytochromecof Apoptotic and Necrotic Cells Is Detected by Monoclonal Antibody Binding and Mimicked by Association of the Native Antigen with Synthetic Phospholipid Vesicles†

1 reference

https://pubmed.ncbi.nlm.nih.gov/17761303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oltipraz chemoprevention trial in Qidong, People's Republic of China: Unaltered oxidative biomarkers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17761303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antioxidant functions of cytochrome c

1 reference

https://pubmed.ncbi.nlm.nih.gov/17761303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformation of ferricytochrome c. IV. Relationship between optical absorption and protein conformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17761303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electron paramagnetic resonance of beef-heart ferricytochrome c

1 reference

https://pubmed.ncbi.nlm.nih.gov/17761303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.FREERADBIOMED.2007.06.022

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

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