(Q33816078)

29 July 2017

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title

Human biological relevance and the use of threshold-arguments in regulatory genotoxicity assessment: experience with pharmaceuticals (English)

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29 July 2017

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Müller L

1

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29 July 2017

Kasper P

series ordinal

2

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29 July 2017

language of work or name

English

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publication date

1 January 2000

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29 July 2017

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29 July 2017

volume

464

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29 July 2017

issue

1

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29 July 2017

page(s)

19-34

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Interpretation of the biological relevance of genotoxicity test results: the importance of thresholds

29 July 2017

cites work

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ICH-harmonised guidances on genotoxicity testing of pharmaceuticals: evolution, reasoning and impact.

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Genotoxicity testing of biotechnology-derived products. Report of a GUM task force. Gesellschaft für Umweltmutationsforschung

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7 January 2021

Anticancer drugs: an underestimated risk or an underutilised resource in mutagenesis?

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Genotoxicity of 17 gyrase- and four mammalian topoisomerase II-poisons in prokaryotic and eukaryotic test systems

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7 January 2021

Fluoroquinolone antibacterials enhance UVA-induced skin tumors

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7 January 2021

The photomutagenicity of fluoroquinolones in tests for gene mutation, chromosomal aberration, gene conversion and DNA breakage (Comet assay).

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7 January 2021

An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro. Studies with human and rat liver microsomes

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7 January 2021

Cytogenetic assay of potential mutagenicity in vivo of two narcotic analgesics

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7 January 2021

Effects of morphine sulphate on the germ cells of male mice

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7 January 2021

Opium: A potential urinary bladder carcinogen in man

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7 January 2021

Opium and oesophageal cancer in Iran

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7 January 2021

Series: current issues in mutagenesis and carcinogenesis, No. 65. The genotoxicity and carcinogenicity of paracetamol: a regulatory (re)view

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7 January 2021

Discrimination between genotoxicity and cytotoxicity in the induction of DNA double-strand breaks in cells treated with etoposide, melphalan, cisplatin, potassium cyanide, Triton X-100, and gamma-irradiation

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7 January 2021

A quantitative assessment of the cytotoxicity associated with chromosomal aberration detection in Chinese hamster ovary cells

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7 January 2021

DNA synthesis inhibition as an indirect mechanism of chromosome aberrations: comparison of DNA-reactive and non-DNA-reactive clastogens

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7 January 2021

Detection of in vitro clastogens and spindle poisons by the mouse lymphoma assay using the microwell method: interim report of an international collaborative study.

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7 January 2021

Evaluation of the mouse lymphoma tk assay (microwell method) as an alternative to the in vitro chromosomal aberration test

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7 January 2021

The need for long-term treatment in the mouse lymphoma assay

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7 January 2021

Effect of pH shifts on the mutant frequency at the thymidine kinase locus in mouse lymphoma L5178Y TK+/- cells.

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7 January 2021

The utility of two rodent species in carcinogenic risk assessment of pharmaceuticals in Europe.

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7 January 2021

10.1016/S1383-5718(99)00163-1

Identifiers

DOI

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29 July 2017

1 reference