(Q33825109)

29 July 2017

title

Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells (English)

1 reference

29 July 2017

Alexandra K Leamy

1

1 reference

29 July 2017

Robert A Egnatchik

2

1 reference

29 July 2017

Masakazu Shiota

3

1 reference

29 July 2017

Pavlina T Ivanova

4

1 reference

29 July 2017

David S Myers

5

1 reference

29 July 2017

H Alex Brown

6

1 reference

29 July 2017

Jamey D Young

7

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29 July 2017

publication date

23 May 2014

1 reference

Journal of Lipid Research

29 July 2017

published in

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29 July 2017

volume

55

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29 July 2017

issue

7

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29 July 2017

page(s)

1478-1488

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describes a project that uses

29 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4076085/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes

1 reference

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Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease

4 July 2018

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Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications

4 July 2018

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CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action.

4 July 2018

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Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model

4 July 2018

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Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition

4 July 2018

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4 July 2018

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4 July 2018

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Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

4 July 2018

1 reference

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Oleate blocks palmitate-induced abnormal lipid distribution, endoplasmic reticulum expansion and stress, and insulin resistance in skeletal muscle

4 July 2018

1 reference

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4 July 2018

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Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death

4 July 2018

1 reference

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Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis

4 July 2018

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Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells

4 July 2018

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Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase

4 July 2018

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4 July 2018

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Application of metabolic flux analysis to identify the mechanisms of free fatty acid toxicity to human hepatoma cell line

4 July 2018

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Signal integration in the endoplasmic reticulum unfolded protein response

4 July 2018

1 reference

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4 July 2018

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Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

4 July 2018

1 reference

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Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

4 July 2018

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Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

4 July 2018

1 reference

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Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis.

4 July 2018

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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

4 July 2018

1 reference

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

4 July 2018

1 reference

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Triglyceride accumulation protects against fatty acid-induced lipotoxicity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076085

Inhibition of phosphatidylcholine synthesis induces expression of the endoplasmic reticulum stress and apoptosis-related protein CCAAT/enhancer-binding protein-homologous protein (CHOP/GADD153).

4 July 2018

1 reference

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4 July 2018

1 reference

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4 July 2018

1 reference

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4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076085

Palmitate-induced apoptosis can occur through a ceramide-independent pathway

4 July 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M050237

Stimulation of lipogenesis as well as fatty acid oxidation protects against palmitate-induced INS-1 beta-cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M050237

Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M050237

Decrease in membrane phospholipid unsaturation induces unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M050237

Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M050237

Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M050237

Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M050237

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M050237

Modulation of lipid-induced ER stress by fatty acid shape

21 January 2018

1 reference

12 December 2020

Effect of fatty acids on physical properties of microsomes from isolated perfused rat liver

1 reference

12 December 2020

Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis

1 reference

12 December 2020

Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance

1 reference

12 December 2020

Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis

1 reference

12 December 2020

Identifiers

DOI

10.1194/JLR.M050237

1 reference

29 July 2017

1 reference

29 July 2017

1 reference