(Q33834097)

29 July 2017

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title

Molecular modeling of mammalian cytochromes P450: application to study enzyme function (English)

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29 July 2017

Szklarz GD

1

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29 July 2017

Graham SE

series ordinal

2

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29 July 2017

Paulsen MD

series ordinal

3

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29 July 2017

publication date

1 January 2000

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29 July 2017

published in

Vitamins and Hormones

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29 July 2017

volume

58

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29 July 2017

page(s)

53-87

1 reference

Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer

29 July 2017

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Structure of cytochrome P450eryF involved in erythromycin biosynthesis

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7 January 2021

A three-dimensional protein model for human cytochrome P450 2D6 based on the crystal structures of P450 101, P450 102, and P450 108

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7 January 2021

Analysis of four residues within substrate recognition site 4 of human cytochrome P450 3A4: role in steroid hydroxylase activity and alpha-naphthoflavone stimulation.

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7 January 2021

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7 January 2021

A three-dimensional model of aromatase cytochrome P450.

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7 January 2021

An active site substitution, F87V, converts cytochrome P450 BM-3 into a regio- and stereoselective (14S,15R)-arachidonic acid epoxygenase

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Novel method for the rapid evaluation of packing in protein structures

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Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4. Role of residues 210 and 211 in flavonoid activation and substrate specificity

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7 January 2021

Crystal structure and refinement of cytochrome P450terp at 2.3 A resolution

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7 January 2021

Structure and function of cytochromes P450: a comparative analysis of three crystal structures

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Secobarbital-mediated inactivation of cytochrome P450 2B1 and its active site mutants. Partitioning between heme and protein alkylation and epoxidation

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7 January 2021

Identification of Three Key Residues in Substrate Recognition Site 5 of Human Cytochrome P450 3A4 by Cassette and Site-Directed Mutagenesis

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7 January 2021

Structural determinants of progesterone hydroxylation by cytochrome P450 2B5: the role of nonsubstrate recognition site residues

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7 January 2021

Significance of Glycine 478 in the Metabolism of N-Benzyl-1-aminobenzotriazole to Reactive Intermediates by Cytochrome P450 2B1

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7 January 2021

Probing the active site of cytochrome P450 2B1: metabolism of 7-alkoxycoumarins by the wild type and five site-directed mutants

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7 January 2021

A preliminary 3D model for cytochrome P450 2D6 constructed by homology model building

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7 January 2021

A geometric approach to macromolecule-ligand interactions

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7 January 2021

A detailed molecular model for human aromatase

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7 January 2021

The interpretation of protein structures: Estimation of static accessibility

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7 January 2021

Three-dimensional models of human and other mammalian microsomal P450s constructed from an alignment with P450102 (P450bm3)

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7 January 2021

Molecular modelling of members of the P4502A subfamily: application to studies of enzyme specificity

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7 January 2021

Molecular modelling of CYP1A subfamily members based on an alignment with CYP102: rationalization of CYP1A substrate specificity in terms of active site amino acid residues

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7 January 2021

An evolutionary trace method defines binding surfaces common to protein families

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7 January 2021

Three-dimensional modelling of human cytochrome P450 1A2 and its interaction with caffeine and MeIQ.

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7 January 2021

A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding

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7 January 2021

New aspects of electron transfer revealed by the crystal structure of a truncated bovine adrenodoxin, Adx(4-108)

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7 January 2021

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

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7 January 2021

Crystal structure of nitric oxide reductase from denitrifying fungus Fusarium oxysporum

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7 January 2021

A 175-psec molecular dynamics simulation of camphor-bound cytochrome P-450cam

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7 January 2021

Predicting the product specificity and coupling of cytochrome P450cam

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7 January 2021

Binding free energy calculations for P450cam-substrate complexes

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7 January 2021

Controlling the regiospecificity and coupling of cytochrome P450cam: T185F mutant increases coupling and abolishes 3-hydroxynorcamphor product

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7 January 2021

A close family resemblance: the importance of structure in understanding cytochromes P450

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7 January 2021

High-resolution crystal structure of cytochrome P450cam

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7 January 2021

Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

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7 January 2021

The flavoprotein domain of P450BM-3: expression, purification, and properties of the flavin adenine dinucleotide- and flavin mononucleotide-binding subdomains

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7 January 2021

Use of homology modeling in conjunction with site-directed mutagenesis for analysis of structure-function relationships of mammalian cytochromes P450.

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7 January 2021

Molecular modeling of cytochrome P450 3A4

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7 January 2021

Application of 3-Dimensional Homology Modeling of Cytochrome P450 2B1 for Interpretation of Site-Directed Mutagenesis Results

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7 January 2021

Site-Directed Mutagenesis as a Tool for Molecular Modeling of Cytochrome P450 2B1

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7 January 2021

Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.

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7 January 2021

Cytochrome b5, its functions, structure and membrane topology

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7 January 2021

Molecular modeling of the 3-D structure of cytochrome P-450scc

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7 January 2021

Structure-function relationships of human liver cytochromes P450 3A: aflatoxin B1 metabolism as a probe

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7 January 2021

The human hepatic cytochromes P450 involved in drug metabolism

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7 January 2021

Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4/NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5.

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7 January 2021

A predicted three-dimensional structure of human cytochrome P450: implications for substrate specificity

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7 January 2021

10.1016/S0083-6729(00)58021-2

Identifiers

DOI

1 reference

29 July 2017

1 reference