(Q33840373)

29 July 2017

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title

Covalent modification as a strategy to block protein-protein interactions with small-molecule drugs (English)

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protein-protein interaction

29 July 2017

main subject

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Way JC

1

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29 July 2017

publication date

1 February 2000

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Current Opinion in Chemical Biology

29 July 2017

published in

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29 July 2017

volume

4

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29 July 2017

issue

1

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29 July 2017

page(s)

40-46

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Structure of human methionine aminopeptidase-2 complexed with fumagillin

29 July 2017

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Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand

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Crystal structures of influenza virus hemagglutinin in complex with high-affinity receptor analogs

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Inhibiting the assembly of protein-protein interfaces.

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From peptide to non-peptide. 3. Atropisomeric GPIIbIIIa antagonists containing the 3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione nucleus

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FP-21399 blocks HIV envelope protein-mediated membrane fusion and concentrates in lymph nodes

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7 January 2021

The acetylation of hemoglobin by aspirin. In vitro and in vivo

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7 January 2021

Studies on the direct neutral penicilloylation of functional groups occurring on proteins

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7 January 2021

The reaction of penicillin with proteins

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7 January 2021

Allergy to Penicillin and Related Antibiotics: Antigenic and Immunochemical Mechanism

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Rational approaches to chemotherapy: antisickling agents

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Sickle Cell (II): Many Agents Near Trials

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Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

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7 January 2021

CRM1 is an export receptor for leucine-rich nuclear export signals

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7 January 2021

Structure-Based Design of a Potent, Selective, and Irreversible Inhibitor of the Catalytic Domain of the erbB Receptor Subfamily of Protein Tyrosine Kinases

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7 January 2021

Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

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7 January 2021

Discovering high-affinity ligands for proteins

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7 January 2021

NMR-based discovery of phosphotyrosine mimetics that bind to the Lck SH2 domain

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7 January 2021

Anatomy of hot spots in protein interfaces

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7 January 2021

Penicillins and cephalosporins are active site-directed acylating agents: evidence in support of the substrate analogue hypothesis

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7 January 2021

Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.

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7 January 2021

Aspirin-like molecules that covalently inactivate cyclooxygenase-2.

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7 January 2021

Stereospecific Alkylation with Asymmetric Reagents

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7 January 2021

10.1016/S1367-5931(99)00049-6

Identifiers

DOI

1 reference

29 July 2017

1 reference