(Q33841158)

29 July 2017

1 reference

title

Central chemoreception in wakefulness and sleep: evidence for a distributed network and a role for orexin (English)

1 reference

29 July 2017

Eugene Nattie

1

1 reference

29 July 2017

Aihua Li

series ordinal

2

1 reference

29 July 2017

language of work or name

English

0 references

publication date

4 February 2010

1 reference

Journal of Applied Physiology

29 July 2017

published in

1 reference

29 July 2017

volume

108

1 reference

29 July 2017

issue

5

1 reference

29 July 2017

page(s)

1417-1424

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The orexin receptor 1 (OX1R) in the rostral medullary raphe contributes to the hypercapnic chemoreflex in wakefulness, during the active period of the diurnal cycle

29 July 2017

cites work

1 reference

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Activation of the retrotrapezoid nucleus by posterior hypothalamic stimulation

5 July 2018

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Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity

5 July 2018

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5 July 2018

Breathing with phox2b

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Embryonic emergence of the respiratory rhythm generator.

5 July 2018

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Chemosensory responses to CO2 in multiple brain stem nuclei determined using a voltage-sensitive dye in brain slices from rats

5 July 2018

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Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P.

5 July 2018

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Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation

5 July 2018

1 reference

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Focal acidosis in the pre-Botzinger complex area of awake goats induces a mild tachypnea

5 July 2018

1 reference

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The dual role of the orexin/hypocretin system in modulating wakefulness and respiratory drive

5 July 2018

1 reference

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GFP-expressing locus ceruleus neurons from Prp57 transgenic mice exhibit CO2/H+ responses in primary cell culture

5 July 2018

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Congenital central hypoventilation syndrome (CCHS) and sudden infant death syndrome (SIDS): kindred disorders of autonomic regulation

5 July 2018

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The 2008 Carl Ludwig Lecture: retrotrapezoid nucleus, CO2 homeostasis, and breathing automaticity

5 July 2018

1 reference

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Central chemoreception is a complex system function that involves multiple brain stem sites

5 July 2018

1 reference

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Orexinergic modulation of breathing across vigilance states

5 July 2018

1 reference

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Focal CO2 dialysis in raphe obscurus does not stimulate ventilation but enhances the response to focal CO2 dialysis in the retrotrapezoid nucleus

5 July 2018

1 reference

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Selective lesion of retrotrapezoid Phox2b-expressing neurons raises the apnoeic threshold in rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

An essential role for orexins in emergence from general anesthesia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

The retrotrapezoid nucleus and central chemoreception

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Orexin neuronal circuitry: role in the regulation of sleep and wakefulness

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Control of hypothalamic orexin neurons by acid and CO2.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

The cerebellar fastigial nucleus contributes to CO2-H+ ventilatory sensitivity in awake goats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Promotion of sleep by targeting the orexin system in rats, dogs and humans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Vigilance state-dependent attenuation of hypercapnic chemoreflex and exaggerated sleep apnea in orexin knockout mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Afferent and efferent connections of the rat retrotrapezoid nucleus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Roles of orexins and orexin receptors in central regulation of feeding behavior and energy homeostasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Central chemoreception 2005: a brief review

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Peripheral chemoreceptor inputs to retrotrapezoid nucleus (RTN) CO2-sensitive neurons in rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Distinct rhythm generators for inspiration and expiration in the juvenile rat

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Hypothalamic regulation of sleep and circadian rhythms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Somatic vs. dendritic responses to hypercapnia in chemosensitive locus coeruleus neurons from neonatal rats.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Homing in on the specific phenotype(s) of central respiratory chemoreceptors.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Respiratory control by ventral surface chemoreceptor neurons in rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Breathing: rhythmicity, plasticity, chemosensitivity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Chemosensitivity of serotonergic neurons in the rostral ventral medulla

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Multiple sites for central chemoreception: their roles in response sensitivity and in sleep and wakefulness

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

CO2, brainstem chemoreceptors and breathing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Neurons containing hypocretin (orexin) project to multiple neuronal systems

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Effects of unilateral lesions of retrotrapezoid nucleus on breathing in awake rats.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Effect of CO2 on the metabolic and ventilatory responses to ambient temperature in conscious adult and newborn rats.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Central chemosensitivity and the reaction theory

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Studies on the respiratory response to disturbances of acid-base balance, with deductions concerning the ionic composition of cerebral interstitial fluid

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

In vivo study on medullary H(+)-sensitive neurons.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Fluorescence location of RVLM kainate microinjections that alter the control of breathing.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Historical development of current concepts on central chemosensitivity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Lesions in retrotrapezoid nucleus decrease ventilatory output in anesthetized or decerebrate cats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Ventilatory responses to acute CO2 exposure in the rat

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Elimination of central chemosensitivity by coagulation of a bilateral area on the ventral medullary surface in awake cats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

PHOX2B in respiratory control: lessons from congenital central hypoventilation syndrome and its mouse models.

5 July 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Locus coeruleus noradrenergic neurons and CO2 drive to breathing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Effect of perinatal hypercapnia on the adult ventilatory response to carbon dioxide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Chemosensitive serotonergic neurons are closely associated with large medullary arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Commentaries on Viewpoint: Central chemoreception is a complex system function that involves multiple brain stem sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Widespread sites of brain stem ventilatory chemoreceptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Contribution of orexin in hypercapnic chemoreflex: evidence from genetic and pharmacological disruption and supplementation studies in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Activation of Orexin B receptors in the pontine Kölliker-Fuse nucleus modulates pre-inspiratory hypoglossal motor activity in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

ATP is a mediator of chemosensory transduction in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Effects on breathing in awake and sleeping goats of focal acidosis in the medullary raphe

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Effects on breathing of focal acidosis at multiple medullary raphe sites in awake goats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

CO2 dialysis in one chemoreceptor site, the RTN: stimulus intensity and sensitivity in the awake rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

CO(2) microdialysis in retrotrapezoid nucleus of the rat increases breathing in wakefulness but not in sleep

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Simultaneous inhibition of caudal medullary raphe and retrotrapezoid nucleus decreases breathing and the CO2 response in conscious rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Muscimol dialysis in the retrotrapezoid nucleus region inhibits breathing in the awake rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Neurokinin-1 receptor-expressing neurons in the ventral medulla are essential for normal central and peripheral chemoreception in the conscious rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

CO2 dialysis in nucleus tractus solitarius region of rat increases ventilation in sleep and wakefulness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

CO2 dialysis in the medullary raphe of the rat increases ventilation in sleep.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Retrotrapezoid nucleus lesions decrease phrenic activity and CO2 sensitivity in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Substance P-saporin lesion of neurons with NK1 receptors in one chemoreceptor site in rats decreases ventilation and chemosensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Medullary serotonergic neurones and adjacent neurones that express neurokinin-1 receptors are both involved in chemoreception in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Multiple central chemoreceptor sites: cell types and function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Intrinsic chemosensitivity of individual nucleus tractus solitarius (NTS) and locus coeruleus (LC) neurons from neonatal rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Hans Loeschcke, Robert Mitchell and the medullary CO2 chemoreceptors: a brief historical review

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

CO2 activates orexin-containing neurons in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Quantification of the response of rat medullary raphe neurones to independent changes in pH(o) and P(CO2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Orexin stimulates breathing via medullary and spinal pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

Orexin-A projections to the caudal medulla and orexin-induced c-Fos expression, food intake, and autonomic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.01261.2009

ROLE OF CEREBRAL FLUIDS IN CONTROL OF RESPIRATION AS STUDIED IN UNANESTHETIZED GOATS.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Chemosensitivity of the respiratory center influence of changes in the H+ and total buffer concentrations in the cerebral ventricles on respiration.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867536

Evidence for central chemoreception in the midline raphé

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20133433

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

CO(2)/H(+) chemoreception in the cat pre-Bötzinger complex in vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20133433

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Possible locations of pH-dependent central chemoreceptors: intramedullary regions with acidic shift of extracellular fluid pH during hypercapnia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20133433

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1152/JAPPLPHYSIOL.01261.2009

1 reference

29 July 2017

1 reference

29 July 2017

1 reference