(Q33853515)

29 July 2017

title

Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53. (English)

1 reference

29 July 2017

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K A Webster

1

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29 July 2017

D J Discher

2

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29 July 2017

S Kaiser

3

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29 July 2017

O Hernandez

4

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29 July 2017

B Sato

5

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29 July 2017

N H Bishopric

6

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29 July 2017

language of work or name

English

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publication date

1 August 1999

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Journal of Clinical Investigation

29 July 2017

published in

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29 July 2017

volume

104

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29 July 2017

issue

3

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29 July 2017

page(s)

239-252

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Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element

29 July 2017

cites work

1 reference

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Myocyte proliferation in end-stage cardiac failure in humans

5 July 2018

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Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand

5 July 2018

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Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell

5 July 2018

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Enhanced expression of p53 and apoptosis induced by blockade of the vacuolar proton ATPase in cardiomyocytes

5 July 2018

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Pacing-induced heart failure in dogs enhances the expression of p53 and p53-dependent genes in ventricular myocytes

5 July 2018

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5 July 2018

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Increased sensitivity of human vascular smooth muscle cells from atherosclerotic plaques to p53-mediated apoptosis

5 July 2018

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Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53

5 July 2018

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Adenovirus E1A inhibits cardiac myocyte-specific gene expression through its amino terminus

5 July 2018

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5 July 2018

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Role of p53 in apoptosis.

5 July 2018

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p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes

5 July 2018

1 reference

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The time window of apoptosis: a new component in the therapeutic strategy for cardiovascular remodeling.

5 July 2018

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Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack.

5 July 2018

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Apoptosis in pressure overload-induced heart hypertrophy in the rat.

5 July 2018

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5 July 2018

p53: puzzle and paradigm

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Preconditioning rabbit cardiomyocytes: role of pH, vacuolar proton ATPase, and apoptosis

5 July 2018

1 reference

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Physical and functional sensitivity of zinc finger transcription factors to redox change

5 July 2018

1 reference

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Analysis of the K-ras and p53 pathways in X-ray-induced lung tumors in the rat.

5 July 2018

1 reference

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

5 July 2018

1 reference

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Apoptosis and necrosis. Basic types and mechanisms of cell death

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

5 July 2018

1 reference

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Reperfusion injury induces apoptosis in rabbit cardiomyocytes

5 July 2018

1 reference

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Tumor spectrum analysis in p53-mutant mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Mechanisms and genes of cellular suicide

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Apoptosis, oncosis, and necrosis. An overview of cell death

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Apoptosis in an interleukin-2-dependent cytotoxic T lymphocyte cell line is associated with intracellular acidification. Role of the Na(+)/H(+)-antiport

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

DNA fragmentation of human infarcted myocardial cells demonstrated by the nick end labeling method and DNA agarose gel electrophoresis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

The contribution of ionic imbalance to ischemia/reperfusion-induced injury.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Apoptosis of rat vascular smooth muscle cells is regulated by p53-dependent and -independent pathways.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Cell acidification in apoptosis: granulocyte colony-stimulating factor delays programmed cell death in neutrophils by up-regulating the vacuolar H(+)-ATPase

5 July 2018

1 reference

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Myocardial contractile function during ischemia and hypoxia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Nucleotide sequence of a cDNA encoding the chicken p53 nuclear oncoprotein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Adenovirus E1A products suppress myogenic differentiation and inhibit transcription from muscle-specific promoters

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Myocardial ischemia and infarction: anatomic and biochemical substrates for ischemic cell death and ventricular arrhythmias

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Induction of the skeletal alpha-actin gene in alpha 1-adrenoceptor-mediated hypertrophy of rat cardiac myocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

The consequences of simulated ischaemia on intracellular Ca2+ and tension in isolated ferret ventricular muscle

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Structure and function of vacuolar class of ATP-driven proton pumps

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Activation of human papillomavirus type 18 E6-E7 oncogene expression by transcription factor Sp1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Molecular regulation of cardiac myocyte adaptations to chronic hypoxia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Role of bicarbonate in pH recovery from intracellular acidosis in the guinea-pig ventricular myocyte

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Inhibition of cell-proliferation by an adenovirus vector expressing the human wild type-p53 protein.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Regulation of cardiomyocyte apoptotic signaling by insulin-like growth factor I.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Effect of vacuolar proton ATPase on pHi, Ca2+, and apoptosis in neonatal cardiomyocytes during metabolic inhibition/recovery

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Regulated expression of a foreign gene targeted to the ischaemic myocardium

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Induction and nuclear accumulation of fos and jun proto-oncogenes in hypoxic cardiac myocytes.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Evidence of Apoptosis in Arrhythmogenic Right Ventricular Dysplasia

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408414

Myocardial cell death and apoptosis in hibernating myocardium

29 October 2018

1 reference

12 December 2020

Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart

1 reference

12 December 2020

Impact of extracellular buffer composition on cardioprotective efficacy of Na+/H+ exchanger inhibitors

1 reference

12 December 2020

Characterisation and validation of a murine model of global ischaemia-reperfusion injury

1 reference

12 December 2020

Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes

1 reference

12 December 2020

Apoptosis in human acute myocardial infarction

1 reference

12 December 2020

"Apoptotic" myocytes in infarct area in rabbit hearts may be oncotic myocytes with DNA fragmentation: analysis by immunogold electron microscopy combined with In situ nick end-labeling

1 reference

12 December 2020

Rb functions to inhibit apoptosis during myocyte differentiation

1 reference

12 December 2020

Apoptosis: basic mechanisms and implications for cardiovascular disease

1 reference

12 December 2020

Myocyte cell death in the diseased heart

1 reference

12 December 2020

Programmed myocyte cell death affects the viable myocardium after infarction in rats

1 reference

12 December 2020

Expression of bcl-2 protein, an inhibitor of apoptosis, and Bax, an accelerator of apoptosis, in ventricular myocytes of human hearts with myocardial infarction

1 reference

12 December 2020

Protons in ischemia: where do they come from; where do they go to?

1 reference

12 December 2020

Role of glycolytic products in damage to ischemic myocardium. Dissociation of adenosine triphosphate levels and recovery of function of reperfused ischemic hearts

1 reference

12 December 2020

1 reference

12 December 2020

Modes of myocardial cell injury and cell death in ischemic heart disease

1 reference

12 December 2020

Apoptosis in the failing human heart

1 reference

12 December 2020

Hypoxia/reoxygenation stimulates Jun kinase activity through redox signaling in cardiac myocytes

1 reference

12 December 2020

Apoptosis in ischemic and reperfused rat myocardium

1 reference

12 December 2020

Intracellular pH and Ca2+ homeostasis in the pH paradox of reperfusion injury to neonatal rat cardiac myocytes

1 reference

12 December 2020

The cellular basis of pacing-induced dilated cardiomyopathy. Myocyte cell loss and myocyte cellular reactive hypertrophy

1 reference

12 December 2020

Apoptosis in myocytes in end-stage heart failure

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI5871

1 reference

29 July 2017

1 reference

29 July 2017

1 reference