(Q33858358)

English

Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

molecular chaperones

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author name string

Matilde Aguilar-Moncayo

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

M Isabel García-Moreno

2

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Ana Trapero

3

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Meritxell Egido-Gabás

4

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Amadeu Llebaria

5

1 reference

Europe PubMed Central

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29 July 2017

José M García Fernández

6

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Europe PubMed Central

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29 July 2017

Carmen Ortiz Mellet

7

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29 July 2017

publication date

30 March 2011

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29 July 2017

Organic and Biomolecular Chemistry

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29 July 2017

9

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PubMed publication ID

29 July 2017

10

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29 July 2017

3698-3713

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Europe PubMed Central

PubMed publication ID

29 July 2017

Recent Insights into Inhibition, Structure, and Mechanism of Configuration-Retaining Glycosidases.

1 reference

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Design and evaluation of oral bioadhesive controlled release formulations of miglitol, intended for prolonged inhibition of intestinal alpha-glucosidases and enhancement of plasma glucagon like peptide-1 levels

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Iminosugars and relatives as antiviral and potential anti-infective agents.

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Natural and synthetic iminosugars as carbohydrate processing enzyme inhibitors for cancer therapy

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A counterintuitive approach to treat enzyme deficiencies: use of enzyme inhibitors for restoring mutant enzyme activity

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Pharmacotherapeutic strategies using small molecules for the treatment of glycolipid lysosomal storage disorders

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Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention.

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Pseudoamide-type pyrrolidine and pyrrolizidine glycomimetics and their inhibitory activities against glycosidases

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Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral alpha-glucosidase inhibitory activity as antitumour agents.

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Castanospermine-trehazolin hybrids: a new family of glycomimetics with tuneable glycosidase inhibitory properties.

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Synthesis and evaluation of isourea-type glycomimetics related to the indolizidine and trehazolin glycosidase inhibitor families

1 reference

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21 January 2018

Chaperone activity of bicyclic nojirimycin analogues for Gaucher mutations in comparison with N-(n-nonyl)deoxynojirimycin

1 reference

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Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring

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6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin: synthesis, biological evaluation, and crystal structure in complex with acid beta-glucosidase

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Optimizing saccharide-directed molecular delivery to biological receptors: design, synthesis, and biological evaluation of glycodendrimer-cyclodextrin conjugates

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21 January 2018

One-step synthesis of non-anomeric sugar isothiocyanates from sugar azides.

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21 January 2018

Synthesis, inhibition properties, and theoretical study of the new nanomolar trehalase inhibitor 1-thiatrehazolin: towards a structural understanding of trehazolin inhibition

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21 January 2018

Synthesis and biological evaluation of guanidine-type iminosugars.

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21 January 2018

Production, purification, and characterization of the debittering enzyme naringinase

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Molecular basis for trehalase inhibition revealed by the structure of trehalase in complex with potent inhibitors

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21 January 2018

Fluorescently tagged iminoalditol glycosidase inhibitors as novel biological probes and diagnostics

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Development and medical application of unsaturated carbaglycosylamine glycosidase inhibitors

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Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses

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21 January 2018

Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease

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21 January 2018

Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease

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21 January 2018

Identifiers

10.1039/C1OB05234A

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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